Details of Disease | DrugMAP

General Information of Disease (ID: DISV60W2)

Disease Name	Noonan syndrome 6
Synonyms	NRAS gene related Noonan syndrome; NRAS Noonan syndrome; Noonan syndrome type 6; NS6; Noonan syndrome caused by mutation in NRAS; Noonan syndrome 6
Definition	Any Noonan syndrome in which the cause of the disease is a mutation in the NRAS gene.
Disease Hierarchy	DIS7Q7DN: Noonan syndrome DISV60W2: Noonan syndrome 6
Disease Identifiers	MONDO ID MONDO_0013186 MESH ID C548084 UMLS CUI C2750732 OMIM ID 613224 MedGen ID 413028

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NRAS	TTW2R9X	Strong	Biomarker	[1]
NRAS	TTW2R9X	Definitive	Autosomal dominant	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NRAS	OTVQ1DG3	Definitive	Autosomal dominant	[2]
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References

1	The RASopathies.Annu Rev Genomics Hum Genet. 2013;14:355-69. doi: 10.1146/annurev-genom-091212-153523. Epub 2013 Jul 15.
2	A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet. 2010 Jan;42(1):27-9. doi: 10.1038/ng.497. Epub 2009 Dec 6.