Details of Disease

General Information of Disease (ID: DISVAF3G)

Disease Name Wilms tumor 6
Synonyms Wilms tumor 6, susceptibility to; Wilms tumour 6, susceptibility to; Wilms tumor type 6; Wilms tumor 6; Wilms tumour type 6; WT6; Wilms tumor 6; WT6; Wilms tumour 6; WT6
Definition Any Wilms tumor in which the cause of the disease is a mutation in the REST gene.
Disease Hierarchy
DISYBXFF: Hereditary Wilms tumor
DISVAF3G: Wilms tumor 6
Disease Identifiers
MONDO ID
MONDO_0014779
UMLS CUI
C3891301
OMIM ID
616806
MedGen ID
855962

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
REST OTLL92LQ Strong Autosomal dominant [1]
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References

1 Mutations in the transcriptional repressor REST predispose to Wilms tumor. Nat Genet. 2015 Dec;47(12):1471-4. doi: 10.1038/ng.3440. Epub 2015 Nov 9.