Details of Disease

General Information of Disease (ID: DISW5DOZ)

• Disease Name: Hypopharynx cancer
• Synonyms: malignant neoplasm of other specified hypopharyngeal site; pharynx cancer of hypopharynx; malignant hypopharyngeal tumour; malignant hypopharyngeal neoplasm; hypopharyngeal cancer; hypopharynx pharynx cancer; malignant hypopharyngeal tumor; malignant tumour of the hypopharynx; malignant neoplasm of the hypopharynx; malignant tumor of posterior wall of hypopharynx; malignant tumor of hypopharynx; malignant tumor of the hypopharynx; malignant neoplasm of hypopharynx; hypural pharynx cancer; malignant neoplasm of ill-defined sites within the lip and oral cavity; malignant tumour of posterior wall of hypopharynx; malignant neoplasm of other specified sites of hypopharynx; malignant neoplasm of posterior wall of hypopharynx; malignant tumour of hypopharynx; malignant neoplasm of posterior hypopharyngeal wall
• Definition: A primary or metastatic malignant neoplasm that affects the hypopharynx.
• Disease Hierarchy:
  DISXLF8Z: Pharynx cancer
  :
  DISW5DOZ: Hypopharynx cancer
• Disease Identifiers:
  MONDO ID: MONDO_0005806
  MESH ID: D007012
  UMLS CUI: C0153398
  MedGen ID: 102266
  SNOMED CT ID: 363399006

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NGFR	TTEDJN4	Limited	Biomarker	[1]
ACACB	TTY84UG	moderate	Altered Expression	[2]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CENPH	OTPOO9LK	Strong	Biomarker	[3]
GRK6	OT4LZTP9	Strong	Biomarker	[4]

References

• [1] Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells.Cancer Lett. 2019 Oct 1;461:144-152. doi: 10.1016/j.canlet.2019.07.011. Epub 2019 Jul 17.
• [2] The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.PeerJ. 2019 Jun 11;7:e7037. doi: 10.7717/peerj.7037. eCollection 2019.
• [3] Role of centromere protein H and Ki67 in relapse-free survival of patients after primary surgery for hypopharyngeal cancer.Asian Pac J Cancer Prev. 2012;13(3):821-5. doi: 10.7314/apjcp.2012.13.3.821.
• [4] Aberrant GRK6 promoter methylation is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.Oncol Rep. 2016 Feb;35(2):1027-33. doi: 10.3892/or.2015.4469. Epub 2015 Dec 1.