Details of Disease

General Information of Disease (ID: DISW7W4V)

Disease Name Peritoneal mesothelioma
Synonyms peritoneum mesothelioma; peritoneal mesothelioma (disease); peritoneal mesothelioma; mesothelioma of the peritoneum; mesothelioma of peritoneum
Disease Class 2C51: Peritoneal cancer
Definition A benign or malignant mesothelial neoplasm that arises from the peritoneum.
Disease Hierarchy
DISKWK9M: Mesothelioma
DIS2ZMIF: Peritoneal neoplasm
DISW7W4V: Peritoneal mesothelioma
ICD Code
ICD-11
ICD-11: 2C51.2
Expand ICD-11
'2C51.2
Expand ICD-10
'C45; 'C45.1; 'C45.7
Disease Identifiers
MONDO ID
MONDO_0006362
UMLS CUI
C1377610
MedGen ID
237171

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
TC-210 DM9S5I1 Phase 1/2 TCR-T cell therapy [1]
Hu-CART meso cells DM9VB4I Phase 1 CAR T Cell Therapy [2]
MCY-M11 DMAESQI Phase 1 CAR-PBMC Cell therapy [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
KAZALD1 OTSFOX2H Limited Genetic Variation [4]
MAPK13 OT0W9GE7 Limited Genetic Variation [4]
TMEM30B OTNSBH84 Limited Genetic Variation [4]
TRAF7 OTW8Q5TF Disputed Genetic Variation [5]
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References

1 ClinicalTrials.gov (NCT03907852) Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03054298) CAR T Cells in Mesothelin Expressing Cancers
3 ClinicalTrials.gov (NCT03608618) Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma. U.S. National Institutes of Health.
4 Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma.Tumour Biol. 2012 Dec;33(6):2031-40. doi: 10.1007/s13277-012-0462-8. Epub 2012 Jul 27.
5 Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.Mod Pathol. 2019 Jan;32(1):88-99. doi: 10.1038/s41379-018-0127-2. Epub 2018 Aug 31.