Details of Disease

General Information of Disease (ID: DISX17PY)

• Disease Name: Lentivirus infection
• Synonyms: Disease caused by Lentivirus; Infections, Lentivirus; Disease due to Lentivirus; Infection, Lentivirus; Lentivirus Infections; Lentivirus Infection
• Definition: Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.
• Disease Hierarchy:
  DISDI77C: Primary viral infectious disease
  DISEM33Q: Infectious disease
  DISX17PY: Lentivirus infection
• Disease Identifiers:
  MONDO ID: MONDO_0022034
  MESH ID: D016180
  UMLS CUI: C0079680
  MedGen ID: 38233
  SNOMED CT ID: 24907000

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GPR137	TTATO6X	Strong	Altered Expression	[1]
LGMN	TTPTWV5	Strong	Biomarker	[2]
LRRC32	TT0FAYT	Strong	Altered Expression	[3]
SLC18A3	TTV8KWS	Strong	Biomarker	[4]
TPP1	TTOVYPT	Strong	Biomarker	[5]
FAM83D	TTFIW7J	Definitive	Altered Expression	[6]

This Disease Is Related to 18 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACER3	OTIVQBG5	Limited	Biomarker	[7]
GTPBP4	OT6ZHAWC	Limited	Biomarker	[8]
SKA1	OTDYJ12A	moderate	Altered Expression	[9]
APOBEC3A	OTYO6F5P	Strong	Biomarker	[10]
C1QTNF6	OT57EPQC	Strong	Biomarker	[11]
DPYSL3	OTINJV20	Strong	Genetic Variation	[12]
EXT1	OTRPALJK	Strong	Altered Expression	[13]
ILF2	OTWWVM9X	Strong	Biomarker	[14]
MYOCD	OTSJNHTH	Strong	Altered Expression	[15]
MYT1L	OTV45MAS	Strong	Biomarker	[4]
NLK	OT2LETFS	Strong	Altered Expression	[16]
OIP5	OTI5C2DE	Strong	Altered Expression	[17]
OVOL2	OTFM1GKF	Strong	Altered Expression	[18]
RAD18	OTQ9PLNT	Strong	Altered Expression	[19]
RNF41	OTN1DQOY	Strong	Biomarker	[20]
SAMHD1	OTBCIBC7	Strong	Biomarker	[21]
SIAH2	OTKED2XN	Strong	Biomarker	[22]
SUN1	OTIU8V4U	Strong	Altered Expression	[23]

References

• [1] Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells. RETRACTED ARTICLESee: Retraction NoticeActa Biochim Biophys Sin (Shanghai). 2014 Nov;46(11):935-41.
• [2] Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.Rev Esp Enferm Dig. 2019 Mar;111(3):214-222. doi: 10.17235/reed.2018.5709/2018.
• [3] Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. doi: 10.1089/aid.2012.0322. Epub 2013 Feb 1.
• [4] Myt1l induced direct reprogramming of pericytes into cholinergic neurons.CNS Neurosci Ther. 2018 Sep;24(9):801-809. doi: 10.1111/cns.12821. Epub 2018 Feb 17.
• [5] TPP1 OB-fold domain protein suppresses cell proliferation and induces cell apoptosis by inhibiting telomerase recruitment to telomeres in human lung cancer cells.J Cancer Res Clin Oncol. 2019 Jun;145(6):1509-1519. doi: 10.1007/s00432-019-02921-3. Epub 2019 Apr 23.
• [6] Upregulation of family with sequence similarity 83 member D expression enhances cell proliferation and motility via activation of Wnt/-catenin signaling and predicts poor prognosis in gastric cancer.Cancer Manag Res. 2019 Jul 22;11:6775-6791. doi: 10.2147/CMAR.S203082. eCollection 2019.
• [7] Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.Pathol Res Pract. 2018 Sep;214(9):1381-1387. doi: 10.1016/j.prp.2018.07.029. Epub 2018 Jul 27.
• [8] GTPBP4 Promotes Gastric Cancer Progression via Regulating P53 Activity.Cell Physiol Biochem. 2018;45(2):667-676. doi: 10.1159/000487160. Epub 2018 Jan 31.
• [9] Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells.Mol Med Rep. 2015 May;11(5):3533-8. doi: 10.3892/mmr.2015.3175. Epub 2015 Jan 9.
• [10] Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes.J Biol Chem. 2010 Apr 16;285(16):12248-54. doi: 10.1074/jbc.M109.090977. Epub 2010 Feb 23.
• [11] C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells.Int J Mol Med. 2019 Jan;43(1):621-629. doi: 10.3892/ijmm.2018.3978. Epub 2018 Nov 6.
• [12] Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model.Int J Oncol. 2015 Jan;46(1):290-8. doi: 10.3892/ijo.2014.2705. Epub 2014 Oct 10.
• [13] A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses.Int J Oncol. 2019 Mar;54(3):859-868. doi: 10.3892/ijo.2019.4688. Epub 2019 Jan 16.
• [14] Interleukin-enhanced binding factor 2 interacts with NLRP3 to inhibit the NLRP3 inflammasome activation.Biochem Biophys Res Commun. 2018 Jun 2;500(2):398-404. doi: 10.1016/j.bbrc.2018.04.087. Epub 2018 Apr 14.
• [15] NF-B inhibits the differentiation of hysteromyoma cells by reducing myocardin expression.Eur Rev Med Pharmacol Sci. 2018 Jul;22(13):4075-4079. doi: 10.26355/eurrev_201807_15397.
• [16] Lentivirusdelivered nemolike kinase small interfering RNA inhibits laryngeal cancer cell proliferation in vitro.Mol Med Rep. 2015 Oct;12(4):5619-24. doi: 10.3892/mmr.2015.4189. Epub 2015 Aug 6.
• [17] Opa interacting protein 5 acts as an oncogene in bladder cancer.J Cancer Res Clin Oncol. 2017 Nov;143(11):2221-2233. doi: 10.1007/s00432-017-2485-4. Epub 2017 Jul 27.
• [18] Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1.Gene. 2017 Feb 5;600:1-8. doi: 10.1016/j.gene.2016.11.034. Epub 2016 Nov 21.
• [19] High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression.Biomed Pharmacother. 2019 Apr;112:108555. doi: 10.1016/j.biopha.2019.01.016. Epub 2019 Feb 21.
• [20] Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.Int J Mol Med. 2019 Apr;43(4):1747-1757. doi: 10.3892/ijmm.2019.4080. Epub 2019 Jan 28.
• [21] SAMHD1: a novel antiviral factor in intrinsic immunity.Future Microbiol. 2012 Sep;7(9):1117-26. doi: 10.2217/fmb.12.81.
• [22] Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth.J Natl Cancer Inst. 2008 Nov 19;100(22):1606-29. doi: 10.1093/jnci/djn365. Epub 2008 Nov 11.
• [23] SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma.Onco Targets Ther. 2017 Jun 2;10:2825-2833. doi: 10.2147/OTT.S79727. eCollection 2017.