Details of Disease

General Information of Disease (ID: DISXNTCR)

Disease Name Spermatogenic failure 14
Synonyms SPGF14; ZMYND15 azoospermia; azoospermia caused by mutation in ZMYND15; spermatogenic failure type 14; spermatogenic failure 14
Definition Any azoospermia in which the cause of the disease is a mutation in the ZMYND15 gene.
Disease Hierarchy
DIS3D1AI: Spermatogenic failure
DISXNTCR: Spermatogenic failure 14
Disease Identifiers
MONDO ID
MONDO_0014366
UMLS CUI
C4014454
OMIM ID
615842
MedGen ID
862891

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ZMYND15 OTFLSHKF Strong Autosomal recessive [1]
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References

1 Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 8;285(41):31418-26. doi: 10.1074/jbc.M110.116418. Epub 2010 Jul 30.