Details of Disease

General Information of Disease (ID: DISXRDA6)

• Disease Name: Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization
• Synonyms: FMAIG; neonatal glomerulopathy due to neprilysin alloimmunization; alloimmune neonatal renal disease; neonatal membranous glomerulopathy with maternal neutral endopeptidase deficiency; fetomaternal alloimmunization with antenatal glomerulopathies; neonatal membranous glomerulopathy with maternal NEP deficiency; neonatal glomerulopathy due to Neprilysin alloimmunization
• Definition: A glomerular disease characterized by severe renal failure and nephrotic syndrome at birth, which rapidly improve in the first weeks of life.
• Disease Hierarchy:
  DISQAMHM: Glomerular disorder
  DISXRDA6: Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization
• Disease Identifiers:
  MONDO ID: MONDO_0019068
  UMLS CUI: C4511239
  MedGen ID: 1384031
  Orphanet ID: 69063
  SNOMED CT ID: 725592009

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MME	DEVN830	Supportive	Autosomal recessive	[1]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MME	OT5Q39P8	Supportive	Autosomal recessive	[1]

References

• [1] Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet. 2004 Oct 2-8;364(9441):1252-9. doi: 10.1016/S0140-6736(04)17142-0.