Details of Disease

General Information of Disease (ID: DISYACTL)

Disease Name	Enterocolitis
Synonyms	enterocolitis (disease); enterocolitis
Disease Class	1A40: Infectious gastroenteritis/colitis
Definition	An inflammatory process affecting the small intestine and colon. Causes include viruses, bacteria, radiation, and antibiotics use.
Disease Hierarchy	DISYKSRF: Genetic disease DISYACTL: Enterocolitis
ICD Code	ICD-11 ICD-11: 1A40.Z Expand ICD-11 '1A40.Z
Disease Identifiers	MONDO ID MONDO_0009172 MESH ID D004760 UMLS CUI C0014356 OMIM ID 226150 MedGen ID 4966 HPO ID HP:0004387 SNOMED CT ID 43752006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
STP-206	DMQ9QM6	Phase 2	NA	[1]
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This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Elfamycin	DM74O8R	Investigative	NA	[2]
Purified secretory immunoglobulin	DM8ZHJT	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL1A	TTPM6HI	Limited	Biomarker	[3]
IL10RB	TTJTRMK	moderate	Biomarker	[4]
IL10	TTT0Q1F	Strong	Biomarker	[5]
KLKB1	TTN0PCX	Strong	Biomarker	[6]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC22A4	DT2EG60	Strong	Genetic Variation	[7]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDX1	OTOHTMJE	moderate	Altered Expression	[8]
NLRC4	OTAIA3NA	moderate	Genetic Variation	[9]
IL10RA	OTOX3D1D	Strong	Genetic Variation	[10]
SERPINA4	OTBK0GG7	Strong	Biomarker	[6]
SPI1	OTVCA1D0	Strong	Biomarker	[11]
SPINK6	OTYKZANJ	Strong	Biomarker	[6]
STX2	OTO2IDDR	Strong	Biomarker	[12]
TTC7A	OTDHLPQM	Strong	Genetic Variation	[13]
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⏷ Show the Full List of 8 DOT(s)

References

1	ClinicalTrials.gov (NCT01954017) STP206 for the Prevention of NEC. U.S. National Institutes of Health.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats.Gastroenterology. 1994 Apr;106(4):960-72. doi: 10.1016/0016-5085(94)90755-2.
4	Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.Adv Immunol. 2014;122:177-210. doi: 10.1016/B978-0-12-800267-4.00005-5.
5	The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice.PLoS One. 2019 Sep 11;14(9):e0221618. doi: 10.1371/journal.pone.0221618. eCollection 2019.
6	The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation.Arch Med Res. 2005 Jan-Feb;36(1):87-95. doi: 10.1016/j.arcmed.2005.02.001.
7	Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31.Biochem Biophys Res Commun. 2005 Dec 2;337(4):1165-75. doi: 10.1016/j.bbrc.2005.09.170. Epub 2005 Oct 6.
8	CDX-1 and CDX-2 are expressed in human colonic mucosa and are down-regulated in patients with Hirschsprung's disease associated enterocolitis.Biochim Biophys Acta. 2001 Sep 28;1537(2):89-100. doi: 10.1016/s0925-4439(01)00056-4.
9	Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome.Front Immunol. 2018 Sep 24;9:2162. doi: 10.3389/fimmu.2018.02162. eCollection 2018.
10	Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation.J Allergy Clin Immunol. 2013 Mar;131(3):825-30. doi: 10.1016/j.jaci.2012.09.025. Epub 2012 Nov 14.
11	Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1.J Clin Microbiol. 2008 Apr;46(4):1330-6. doi: 10.1128/JCM.01255-07. Epub 2008 Feb 13.
12	Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome.J Gastroenterol Hepatol. 2018 Jul;33(7):1353-1356. doi: 10.1111/jgh.14082. Epub 2018 Mar 12.
13	Multiple intestinal atresia with combined immune deficiency.Curr Opin Pediatr. 2014 Dec;26(6):690-6. doi: 10.1097/MOP.0000000000000159.