Details of Disease

General Information of Disease (ID: DISZ97J0)

• Disease Name: Obsolete preimplantation embryonic lethality 1
• Synonyms: Prembl; preimplantation embryonic lethality; preimplantation embryonic lethality 1; PREMBL1; preimplantation embryonic lethality type 1; preimplantation embryonic lethality caused by mutation in TLE6; preimplantation embryonic lethality 1; PREMBL1; TLE6 preimplantation embryonic lethality
• Definition: OBSOLETE. Any preimplantation embryonic lethality in which the cause of the disease is a mutation in the TLE6 gene.
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISZ97J0: Obsolete preimplantation embryonic lethality 1

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TLE6	OTB84O0U	Strong	Autosomal recessive	[1]

References

• [1] TLE6 mutation causes the earliest known human embryonic lethality. Genome Biol. 2015 Nov 5;16:240. doi: 10.1186/s13059-015-0792-0.