Details of Disease

General Information of Disease (ID: DISZXMVL)

• Disease Name: Oral cavity carcinoma
• Synonyms: oral cavity cancer; carcinoma of mouth; carcinoma of the oral cavity; carcinoma of oral cavity; oral cavity carcinoma; mouth carcinoma
• Definition: A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma.
• Disease Hierarchy:
  DISFC6MM: Digestive system carcinoma
  DISLD42D: Oral cancer
  :
  DISH9F1N: Carcinoma
  DISZXMVL: Oral cavity carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0044925
  UMLS CUI: C0151546
  MedGen ID: 57468

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATG2B	TTG6KCU	Strong	Genetic Variation	[1]
DSG3	TTEO4P8	Strong	Biomarker	[2]
MALT1	TTCI81G	Strong	Altered Expression	[3]
NOP2	TTBLG3H	Strong	Biomarker	[4]
NUF2	TTIXBFP	Strong	Biomarker	[5]
STAB1	TTJFEOC	Strong	Biomarker	[6]
STOML2	TTOI329	Strong	Biomarker	[7]

This Disease Is Related to 16 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CIP2A	OTVS2GXA	Limited	Altered Expression	[8]
S100A14	OTVFJJ91	moderate	Biomarker	[9]
ST3GAL2	OT8WM21E	moderate	Altered Expression	[10]
ST3GAL3	OTOORKUE	moderate	Altered Expression	[10]
ATG10	OTVRPC5X	Strong	Genetic Variation	[1]
BRD8	OTIKS3PC	Strong	Biomarker	[4]
DACH1	OTMKNAGG	Strong	Posttranslational Modification	[11]
DCTN3	OTQOSUES	Strong	Altered Expression	[7]
GEMIN2	OT4L6TLL	Strong	Altered Expression	[12]
HNRNPU	OTLQN1E2	Strong	Biomarker	[4]
IGSF1	OT3XD6U2	Strong	Biomarker	[4]
NAA25	OTS3QVF1	Strong	Biomarker	[4]
NRBP1	OTRWEJ65	Strong	Biomarker	[13]
NSUN5	OTBN7RS8	Strong	Biomarker	[4]
PDCD7	OTK5YO7J	Strong	Altered Expression	[14]
TAX1BP1	OTGJMGJ9	Strong	Genetic Variation	[15]

References

• [1] Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma.Sci Rep. 2017 Jul 31;7(1):6887. doi: 10.1038/s41598-017-07270-0.
• [2] Desmoglein 3 - Influence on oral carcinoma cell migration and invasion.Exp Cell Res. 2018 Sep 15;370(2):353-364. doi: 10.1016/j.yexcr.2018.06.037. Epub 2018 Jun 30.
• [3] Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 in oral carcinoma cells and gingival fibroblasts.Odontology. 2013 Jul;101(2):150-5. doi: 10.1007/s10266-012-0079-9. Epub 2012 Jul 3.
• [4] Nucleolar protein p120 expression in oral carcinoma.Anticancer Res. 1999 Mar-Apr;19(2B):1423-6.
• [5] Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer.Int J Oncol. 2016 Oct;49(4):1385-93. doi: 10.3892/ijo.2016.3649. Epub 2016 Aug 5.
• [6] Not CD68 but stabilin-1 expression is associated with the risk of recurrence in patients with oral cavity squamous cell carcinoma.Head Neck. 2019 Jul;41(7):2058-2064. doi: 10.1002/hed.25654. Epub 2019 Jan 16.
• [7] Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions.Cancer Med. 2014 Oct;3(5):1170-84. doi: 10.1002/cam4.307. Epub 2014 Jul 24.
• [8] Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands.Oncotarget. 2014 Jul 15;5(13):4581-602. doi: 10.18632/oncotarget.2127.
• [9] S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest.Oral Oncol. 2012 Mar;48(3):219-25. doi: 10.1016/j.oraloncology.2011.10.001. Epub 2011 Oct 26.
• [10] "Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".J Oral Pathol Med. 2020 Mar;49(3):253-259. doi: 10.1111/jop.12976. Epub 2020 Jan 7.
• [11] The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival.Tumour Biol. 2015 Apr;36(4):2855-61. doi: 10.1007/s13277-014-2913-x. Epub 2014 Dec 7.
• [12] Epigenetic inactivation of E-cadherin by promoter hypermethylation in oral carcinoma cells.Odontology. 2007 Jul;95(1):24-9. doi: 10.1007/s10266-007-0068-6. Epub 2007 Jul 25.
• [13] Integrated genomics approach to identify biologically relevant alterations in fewer samples.BMC Genomics. 2015 Nov 14;16:936. doi: 10.1186/s12864-015-2138-4.
• [14] miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.Int J Cancer. 2018 Dec 1;143(11):2892-2904. doi: 10.1002/ijc.31638. Epub 2018 Oct 4.
• [15] Analysis of the TAX1BP1 gene in head and neck cancer patients.Braz J Otorhinolaryngol. 2010 Mar-Apr;76(2):193-8. doi: 10.1590/S1808-86942010000200008.