Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE06B47)

• DME Name: Cytochrome P450 109B1 (cyp109)
• Synonyms: Cytochrome P450 family 109 subfamily B member 1; Flavocytochrome P450 109B1; P450 109B1; cyp109B1; BSUW23_09845
• Gene Name: CYP109B1
• UniProt ID: U5U1Z3_BACIU
• INTEDE ID: DME1745
• EC Number:
  EC: 1.14.14.1
  Oxidoreductase
  Oxygen paired donor oxidoreductase
  Flavin/flavoprotein donor oxidoreductase
  EC: 1.14.14.1
• Lineage:
  Species: Bacillus anthracis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Bacillales
  Family: Bacillaceae
  Genus: Bacillus
  Species: Bacillus anthracis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEENQVWSVFLYDDVKKVI
  GDKELFSSYMPQQSSAIGNSIINMDPPRHTQIRSVVNKAFTPRVMKQWEPRIQEITDELI
  QKFQGRSEFDLVHDFSYPLPVIVISELLGVPSEHMDQFKTWSDLLVSTPKDKSEEAEEAF
  LEERNKCEEELAAFFANIIEEKRNKPAQDVISILVEAEETGEKLSGEELVPFCTLLLVAG
  NETTTNLISNAMYSILETPDVYNVLRSHPELTPQAVEEALRFRAPAPVLRRIAKRDTEIG
  GHLIKEGDMVLAFVASANRDETKFDRAHLFDIHRHPNPHIAFGHGIHFCLGAPLARLEAK
  IALTSLISAFPHMECVSITPIENSVIYGLKSFRVKM
• Function: This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-ionone	DM6QV8A	N. A.	N. A.	Investigative	[1], [2]

References

• [1] The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis. Mol Biosyst. 2015 Mar;11(3):869-81.
• [2] The promises and risks of probiotic Bacillus species. Acta Biochim Pol. 2018 Dec 6;65(4):509-519.