Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2UNSW)

DME Name	Pyridoxal phosphate phosphatase (PDXP)
Synonyms	Chronophin; PLP phosphatase; Pyridoxalphosphate phosphatase; PDXP; CIN; PLP; PLPP
Gene Name	PDXP
UniProt ID	PLPP_HUMAN
INTEDE ID	DME0585
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	57026
EC Number	EC: 3.1.3.74 Hydrolases Ester bond hydrolase Phosphoric monoester hydrolase EC: 3.1.3.74
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNN SRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRA ELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDP WHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRL ETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED
Function	This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. It participates in vitamin B6 metabolism.
KEGG Pathway	Metabolic pathways (hsa01100 ) Vitamin B6 metabolism (hsa00750 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin B6	DMDBZMV	Vitamin B6 deficiency	5B5D	Approved	[1]
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The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name	Pyridoxal phosphate phosphatase (PDXP) DTT Info
DME DTT Type	Literature-reported

References

1	Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. J Biol Chem. 1992 Aug 5;267(22):15978-83.