Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TT9UYG4)
| DTT Name | Pyridoxal phosphate phosphatase (PDXP) | ||||
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| Synonyms | PLPP; PLP phosphatase; PDXP | ||||
| Gene Name | PDXP | ||||
| DTT Type |
Literature-reported target
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[1] | |||
| BioChemical Class |
Phosphoric monoester hydrolase
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| EC Number |
EC 3.1.3.3
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| Sequence |
MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNN
SRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRA ELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDP WHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRL ETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED |
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| Function |
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
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| KEGG Pathway | |||||
The Drug-Metabolizing Enzyme (DME) Role of This DTT
| DTT DME Name | Pyridoxal phosphate phosphatase (PDXP) | |||||||||||||||||||||||||||
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| Gene Name | PDXP | |||||||||||||||||||||||||||
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1 Approved Drug(s) Metabolized by This DTT
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References