General Information of Drug-Metabolizing Enzyme (DME) (ID: DE7HL3C)

DME Name Cytochrome P450 101D2 (cyp101)
Synonyms Cytochrome P450 family 101 subfamily D member 2; Cytochrome P450-cam D2, Cytochrome P450cam D2; P450 101D2; cyp101D2
Gene Name cyp101
UniProt ID
Q2G8A2_NOVAD
INTEDE ID
DME1525
EC Number EC: 1.14.15.1
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.1
Lineage Species: Novosphingobium aromaticivorans
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Sphingomonadales
Family: Sphingomonadaceae
Genus: Novosphingobium
Species: Novosphingobium aromaticivorans

Subspecies: Novosphingobium aromaticivorans DSM 12444
Tissue Distribution Primarily distributed in human gut.
Sequence
MATNFDEAVRAKVERPANVPEDRVYEIDMYALNGIEDGYHEAWKKVQHPGIPDLIWTPFT
GGHWIATNGDTVKEVYSDPTRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGL
NLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMALADLPLEDIPVLSE
YARQMTRPEGNTPEEMATDLEAGNNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERI
AHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFP
VVSEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGG
PHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR
Function This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Camphor DMWIO46 Acute or chronic pain MG30-MG31 Approved [1], [2]

References

1 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.