Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE7HL3C)

• DME Name: Cytochrome P450 101D2 (cyp101)
• Synonyms: Cytochrome P450 family 101 subfamily D member 2; Cytochrome P450-cam D2, Cytochrome P450cam D2; P450 101D2; cyp101D2
• Gene Name: cyp101
• UniProt ID: Q2G8A2_NOVAD
• INTEDE ID: DME1525
• EC Number:
  EC: 1.14.15.1
  Oxidoreductase
  Oxygen paired donor oxidoreductase
  Iron-sulfur protein donor oxidoreductase
  EC: 1.14.15.1
• Lineage:
  Species: Novosphingobium aromaticivorans
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Alphaproteobacteria
  Order: Sphingomonadales
  Family: Sphingomonadaceae
  Genus: Novosphingobium
  Species: Novosphingobium aromaticivorans
  Subspecies: Novosphingobium aromaticivorans DSM 12444
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MATNFDEAVRAKVERPANVPEDRVYEIDMYALNGIEDGYHEAWKKVQHPGIPDLIWTPFT
  GGHWIATNGDTVKEVYSDPTRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGL
  NLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMALADLPLEDIPVLSE
  YARQMTRPEGNTPEEMATDLEAGNNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERI
  AHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFP
  VVSEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGG
  PHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR
• Function: This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Camphor	DMWIO46	Acute or chronic pain	MG30-MG31	Approved	[1], [2]

References

• [1] Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
• [2] A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.