Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEA5OYT)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; ftsI; NCTC12078_02492
Gene Name	ftsI
UniProt ID	A0A4U8WDG3_9FLAO
INTEDE ID	DME2046
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Chryseobacterium gleum Kingdom: Bacteria Phylum: Bacteroidetes Class: Flavobacteriia Order: Flavobacteriales Family: Flavobacteriaceae Genus: Chryseobacterium Species: Chryseobacterium gleum
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNPRHLKILSILIIIAVIFIARLSYLQLFTDRYALNAANTSIKTEYVIPQRGVIFDRNGK ILVGNQPAYEISFTQALMKPDFDTAAFCNLMKITEKDFINRINKIKTEKYYSKLTPMTFL KDLSREDIARVQEIIFKYPAFSIVQRPQRQYEVSTSGNLLGYTSEVNDREIRKDSTYYLP GDLIGKAGVEKSYEKELRGIKGIKYIQKDIKLRSVGPYKNGTLDRDVVTGKDITLTIDYD LQRMAEEMLVNKHGAIVALDPNNGEVLVAATGPDIDPNLFTGPNKSKNLYALSKDTIYEN KPTFDRSLQAAYPPGSTFKLLTALAAMQMGLMDEKTIFPCGGGFYYKGKRIKGHGGADPL IPSIQVSSNCFFTYAFIKIIKKYPGNPSRGVDEWKKIMSSFGVGEFLNNDFAVGAKGRIP SGDFYERRFKAIMKASGSKRQDFKDWDEMSTGAIYNGMGQGDVLVTPIQLANYVAAIANK GWYYTPHIVKSIDGKPNPDPRFKKKHQTLVDKKHFDPVLKGMEAVVLAGTARGLKSNDFT QLAKTGTAQVPQGKDNSIFVLIAPADKPKIVVVAVMEHAGFGATWAGPASTVIAEKYITG DLKREHLYKKMVTSSFMPEYKRQWIADLKRKGLYKEPKPDSLKLKKIQDSLNQAKKKKEA LQKKLQLESSKTKKQ
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[1]
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References

1	Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum. Antimicrob Agents Chemother. 2002 Sep;46(9):2791-6.