Details of the Drug

General Information of Drug (ID: DMS9503)

• Drug Name: Benzylpenicillin
• Synonyms: penicillin g; Benzylpenicillinic acid; Free penicillin II; Pencillin G; 61-33-6; Benzylpenicillin G; Bencilpenicilina; Benzylpenicillinum; Benzyl penicillin; Free penicillin G; Dropcillin; Pharmacillin; Gelacillin; Liquacillin; Benzopenicillin; Cilopen; Pradupen; Benzylpenicilline; Specilline G; Cilloral; Cosmopen; Ursopen; Galofak; Free benzylpenicillin; Compocillin G; Phenylacetamidopenicillanic acid; 6-(2-Phenylacetamido)penicillanic acid; Pfizerpen; Benzyl-6-aminopenicillinic acid

Indication

Disease Entry	ICD 11	Status	REF
Actinomycosis	N.A.	Approved	[1]
Acute otitis media	AB00	Approved	[2]
Anthrax	1B97	Approved	[3]
Bacterial endocarditis	N.A.	Approved	[4]
Botulism	1A11	Approved	[5]
Cervicofacial actinomycosis	N.A.	Approved	[6]
Congenital syphilis	N.A.	Approved	[7]
Cutaneous anthrax	N.A.	Approved	[8]
Erysipelas	N.A.	Approved	[9]
Erysipelothrix rhusiopathiae infectious disease	N.A.	Approved	[10]
Gastrointestinal anthrax	N.A.	Approved	[11]
Gonococcal infection of joint	N.A.	Approved	[12]
Inhalational anthrax	N.A.	Approved	[3]
Late latent syphilis	N.A.	Approved	[13]
Latent syphilis	N.A.	Approved	[14]
Latent yaws	N.A.	Approved	[15]
Listeria meningitis	N.A.	Approved	[16]
Lung abscess	N.A.	Approved	[17]
Meningococcal meningitis	N.A.	Approved	[18]
Meningococcemia	N.A.	Approved	[19]
Neonatal sepsis	N.A.	Approved	[20]
Neurosyphilis	N.A.	Approved	[21]
Pasteurella multocida infectious disease	N.A.	Approved	[22]
Pasteurellosis	N.A.	Approved	[23]
Pneumococcal meningitis	N.A.	Approved	[16]
Psoriasis	EA90	Approved	[24]
Rat-bite fever	N.A.	Approved	[25]
Respiratory tract infection	CA45	Approved	[26]
Staphylococcus aureus infection	N.A.	Approved	[27]
Streptococcal pneumonia	N.A.	Approved	[28]
Streptococcal toxic-shock syndrome	N.A.	Approved	[29]
Streptococcus infection	1B53	Approved	[30]
Syphilis	N.A.	Approved	[31]
Tertiary lesion of yaws	N.A.	Approved	[32]
Yaws	N.A.	Approved	[33]
Bejel	N.A.	Investigative	[34]
Latent early syphilis	N.A.	Investigative	[35]
Secondary syphilis	N.A.	Investigative	[36]
Tertiary syphilis	N.A.	Investigative	[37]
Tetanus	1C13	Investigative	[38]

• ATC Code:
  J01CE01: Benzylpenicillin
  J01CE: Beta-lactamase sensitive penicillins
  J01C: BETA-LACTAM ANTIBACTERIALS, PENICILLINS
  J01: ANTIBACTERIALS FOR SYSTEMIC USE
  J: ANTIINFECTIVES FOR SYSTEMIC USE
  S01AA14: Benzylpenicillin
  S01AA: Antibiotics
  S01A: ANTIINFECTIVES
  S01: OPHTHALMOLOGICALS
  S: SENSORY ORGANS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 334.4
  Logarithm of the Partition Coefficient (xlogp); 1.8
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [39]
  Clearance: The clearance of drug is 560 mL/min in healthy humans []
  Half-life: The concentration or amount of drug in body reduced by one-half in 0.4C0.9 hours [40]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 564.6676 micromolar/kg/day [41]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.4% [40]
  Vd: The volume of distribution (Vd) of drug is 0.53-0.67 L/kg []
• Chemical Identifiers:
  Formula: C16H18N2O4S
  IUPAC Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  Canonical SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C
  InChI: InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
  InChIKey: JGSARLDLIJGVTE-MBNYWOFBSA-N
• Cross-matching ID:
  PubChem CID: 5904
  ChEBI ID: CHEBI:18208
  CAS Number: 61-33-6
  TTD ID: D00QAR
  VARIDT ID: DR00488
  INTEDE ID: DR2164
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein 1 (Bact pbp)	TTTKCMH	PBPA_ECOLI ; PBPB_ECOLI ; PBPC_ECOLI	Binder	[42]
Bacterial Penicillin binding protein 3 (Bact mrcA)	TT85JMW	FTSI_ECOLI	Binder	[43]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 3A1 (SLCO3A1)	DTVNRXW	SO3A1_HUMAN	Substrate	[44]
Organic anion transporting polypeptide 4A1 (SLCO4A1)	DT8H2IC	SO4A1_HUMAN	Substrate	[44]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[45]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[44]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[46]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[47]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[48]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DEV0KWQ	Q8KT52_9BACT	Substrate	[49]
N-acylhomoserine lactone acylase (lacA)	DEIU0XN	A0A0A1VBK6_9BURK	Substrate	[50]
Beta-lactamase (blaB)	DET9I1W	BLAC_BACUN	Substrate	[51]
Beta-lactamase (blaB)	DENJ2SQ	BLAB_BACFG	Substrate	[49]
Beta-lactamase (blaB)	DE37FJH	C6JIU1_FUSVA	Substrate	[49]
Beta-lactamase (blaB)	DEAILCM	A0A246EJV2_9BACT	Substrate	[52]
Beta-lactamase (blaB)	DERPJ4F	A0A2S8IKB0_BURCE	Substrate	[53]
Beta-lactamase (blaB)	DESIWFO	Q8GQK7_9FLAO	Substrate	[54]
Beta-lactamase (blaB)	DEQX0DG	Q8RIK5_FUSNN	Substrate	[55]
Beta-lactamase (blaB)	DEBAZ7H	F9DGI4_9BACT	Substrate	[52]
Beta-lactamase (blaB)	DEA5OYT	A0A4U8WDG3_9FLAO	Substrate	[56]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Gene/Protein Processing	[57]
Annexin A8 (ANXA8)	OTLSSQCY	ANXA8_HUMAN	Gene/Protein Processing	[57]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[58]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Gene/Protein Processing	[59]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Gene/Protein Processing	[57]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Gene/Protein Processing	[60]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Gene/Protein Processing	[57]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Gene/Protein Processing	[57]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[60]
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Gene/Protein Processing	[61]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Benzylpenicillin (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Anisindione	DM2C48U	Moderate	Increased risk of bleeding by the combination of Benzylpenicillin and Anisindione.	Coagulation defect [3B10]	[62]

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