Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEA65D8)
| DME Name | Ribosomal 23S RNA methyltransferase Erm (erm) | ||||
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| Synonyms | Ribosomal RNA methyltransferase Erm; 23S rRNA methyltransferase Erm; 23S ribosomal RNA methyltransferase Erm; NCTC11913_00479; erm(X) | ||||
| Gene Name | erm(X) | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 2.1.1.182 | ||||
| Lineage | Species: Corynebacterium jeikeium | ||||
| Tissue Distribution | Primarily distributed in human skin. | ||||
| Sequence |
MSTYGYGRHEHGQNFLTDHKIINSIVDLVKESSGPIIEIGPGSGALTHPLSRLGRPITAV
EVDAKLAAKLTKKTASASVEVVHGDFLNFPLPATPCVIVGNIPFHLTTAILRELLHAPAW TDAVLLMQWEVARRRAGVGASTMMTAQWSPWFTFHLGSRVPRSAFRPQPNVDGGILVIRR VGDPKIPIEQRKAFQAMVHTVFTARGRGIGEILRRAGLFSSRSETQSWLRSRGIDPATLP PRLRTSDWIDLFQVTGFSPPRHRPISQSGSSQRPPQRKKRGRRR |
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| Function |
This enzyme introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. And Strains lacking the methylase are resistant to kasugamycin.
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Molecular Interaction Atlas (MIA) of This DME
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2 Approved Drug(s) Metabolized by This DME
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