Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBAZ7H)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase induction signal transducer AmpG; ampG; HMPREF9144_0774
Gene Name	ampG
UniProt ID	F9DGI4_9BACT
INTEDE ID	DME1539
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Prevotella pallens Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Prevotellaceae Genus: Prevotella Species: Prevotella pallens
Tissue Distribution	Primarily distributed in human gut.
Sequence	MQEPNIKKRVSPWAWVSTLYFAEGLPNAAVVLVSLVFYQEMGLSDAEATFYTSWFYLPWV IKPLWSPFLDLIKTKRWWVLSMQMLLGAAFAGVAFTINTSFWLQGTICFFWLLAISSATH DVGADGFYMLGLESHEQAFFVGIRSTFYRISMVVGKGGLVALAGLLQEYMKVQLSWSLVF YGLSALFIGLSLYHKCILPKPITDVEHTQLSVSTLFKEFLDTFVSFFRKKEVFVAIAFML LFRLPEALLNTVGPLFLRATSEKGGLALSLEAFGVVNGVVGVVGLLLGGILGGLVASKGG LKKWLWPMTFAITLPNIAYVYLGYAMPSTLFAVGVAIFVENFGYGFGFSAYMLFMLYFSQ GEHKTSHYALCTGFMALSMMLPGLFAGALAEAVGYSLFFVLVMVACIFPFMVASLLKIDP KFGKKDI
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[1]
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References

1	Beta-lactamase production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens genotypes and in vitro susceptibilities to selected antimicrobial agents. Antimicrob Agents Chemother. 1999 Oct;43(10):2383-8.