Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBKS91)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; blaIMP
Gene Name	blaIMP
UniProt ID	A0A1B1FBM9_ACIBA
INTEDE ID	DME1342
Gene ID	8458023
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Acinetobacter baumannii Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Moraxellaceae Genus: Acinetobacter Species: Acinetobacter baumannii Subspecies: Acinetobacter baumannii ST25 Subspecies: Acinetobacter baumannii ST79
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLISRSIPTYASELT NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK PSKPSN
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

6 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[1]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[2]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[2]
Carbapenem	DMXZU73	N. A.	N. A.	Phase 4	[3]
Ceftazidine	DMPZTRC	N. A.	N. A.	Phase 4	[1]
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⏷ Show the Full List of 6 Approved Drug(s)

References

1	Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.
2	A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
3	Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044.