Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEE76YZ)
| DME Name | Naphthalene dioxygenase (doxB) | ||||
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| Synonyms | Naphthalene 1,2-dioxygenase ISP alpha; Naphthalene 1,2-dioxygenase subunit alpha; Naphthalene 1,2-dioxygenase system large oxygenase component; ISP NAP; ND subunit alpha; NDO subunit alpha; doxB | ||||
| Gene Name | doxB | ||||
| UniProt ID | |||||
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| 3D Structure | |||||
| EC Number | EC: 1.14.12.12 | ||||
| Lineage | Species: Pseudomonas furukawaii | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MNYNNKILVSESGLSQKHLIHGDEELFQHELKTIFARNWLFLTHDSLIPAPGDYVTAKMG
IDEVIVSRQNDGSIRAFLNVCRHRGKTLVSVEAGNAKGFVCSYHGWGFGSNGELQSVPFE KDLYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPPLMDYLGDAAWYLEPMFKHSGGL ELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRSGESIFSSLAGNAALPPEGAGL QMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVRARIYRSHLNCTV FPNNSMLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADSVQRTFGPAGFWES DDNDNMETASQNGKKYQSRDSDLLSNLGFGEDVYGDAVYPGVVGKSAIGETSYRGFYRAY QAHVSSSNWAEFEHASSTWHTELTKTTDR |
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| Function |
This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons, and it requires Fe2+.
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Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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1 Investigative Drug(s) Metabolized by This DME
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