Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKGVS4)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase TEM; IRT-4; TEM-1
Gene Name	penA
UniProt ID	PENA_BURM1
INTEDE ID	DME2100
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Burkholderia multivorans Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Burkholderiaceae Genus: Burkholderia Species: Burkholderia multivorans
Tissue Distribution	Primarily distributed in human lung.
Sequence	MQRIGVTDYTILGTVKGAELELVRFTHPFMGFDVPAILGDHVTRMPVPVPFTPRLPRPGR LCDRSEIRPGKPLTRLARTALICRALIRRWMARTSYSDSVNCHTQPISAIFDYKDLRFEP PSNRISPAGQTSVDRLLQLSQGQAVEGQSAVARLTGEKKNHPGAQYANRLSPRIANNHPA TQQTLFELGSGAKERNAINVSYLTALGTPGFTLMLPARMLCGIVSDNNFTQKQLCPSPAR CTRGPAEPAKRGPWLEPGLVIRKDGLRTGKLLSSLRGLCLTVLRFQPTVPCFCRLALSSS VAISSTGLVNFSR
Function	This enzyme hydrolyzes beta-lactam with a substrate specificity for penicillin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1]
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1 Discontinued Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[2]
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References

1	Overcoming an extremely drug resistant (XDR) pathogen: avibactam restores susceptibility to ceftazidime for Burkholderia cepacia complex isolates from cystic fibrosis patients. ACS Infect Dis. 2017 Jul 14;3(7):502-511.
2	Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.