Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKYTSB)

DME Name	Cytochrome P450 101B1 (cyp101)
Synonyms	Cytochrome P450 family 101 subfamily B member 1; Cytochrome P450-cam B1, Cytochrome P450cam B1; P450 101B1; cyp101B1
Gene Name	cyp101
UniProt ID	Q2G637_NOVAD
INTEDE ID	DME1746
EC Number	EC: 1.14.15.1 Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.1
Lineage	Species: Novosphingobium aromaticivorans Kingdom: Bacteria Phylum: Proteobacteria Class: Alphaproteobacteria Order: Sphingomonadales Family: Sphingomonadaceae Genus: Novosphingobium Species: Novosphingobium aromaticivorans Subspecies: Novosphingobium aromaticivorans DSM 12444
Tissue Distribution	Primarily distributed in human gut.
Sequence	MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTANGGHWIAARGDVVREL WGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVMKGLASRFVVALEPKVQAV ARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVE QLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVA AMIGMVALHLARHPEDQRLLRERPDLIPAAADELMRRYPTVAVSRNAVADVDADGVTIRK GDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIRHTTMGVGAHRCVGAGLARMEVIVFLR EWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWRA
Function	This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-ionone	DM6QV8A	N. A.	N. A.	Investigative	[1], [2]
------------------------------------------------------------------------------------

References

1	Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2	A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.