Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPCQ12)

DME Name	Metallo-beta-lactamase (blaM)
Synonyms	Metallo-beta-lactamase NDM-1; New Delhi metallo-beta-lactamase-1; Metallo-beta-lactamase type 2c; Metallo-beta-lactamase type IIc; B2 metallo-beta-lactamase; Beta-lactamase type IIc; NDM-1; blaNDM-1
Gene Name	blaVIM-2
UniProt ID	Q68K11_ALCXX
INTEDE ID	DME1296
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Achromobacter xylosoxidans Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Alcaligenaceae Genus: Achromobacter Species: Achromobacter xylosoxidans
Tissue Distribution	Primarily distributed in human stomach.
Sequence	MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQ SFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRV GGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHS TDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGH GLPGGLDLLKHTTNVVKAHTNRSVVE
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9.