Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DER6EU8)

DME Name Homoserine-O-transsuccinylase (metAA)
Synonyms Homoserine O-acetyltransferase; Homoserine acetyltransferase; Homoserine transacetylase; HTS-like HTA; HAT; HTA
Gene Name metAA
UniProt ID
METAA_THEMA
INTEDE ID
DME1461
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 2.3.1.46
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.46
Lineage Species: Salmonella enterica
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica

Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Tissue Distribution Primarily distributed in human gut.
Sequence
MPINVPSGLPAVKVLAKEGIFVMTEKRAIHQDIRPLEILILNLMPDKIKTEIQLLRLLGN
TPLQVNVTLLYTETHKPKHTPIEHILKFYTTFSAVKDRKFDGFIITGAPVELLPFEEVDY
WEELTEIMEWSRHNVYSTMFICWAAQAGLYYFYGIPKYELPQKLSGVYKHRVAKDSVLFR
GHDDFFWAPHSRYTEVKKEDIDKVPELEILAESDEAGVYVVANKSERQIFVTGHPEYDRY
TLRDEYYRDIGRNLKVPIPANYFPNDDPTKTPILTWWSHAHLFFSNWLNYCIYQKTPYRL
EDIH
Function This enzyme catalyzes the conversion of L-homoserine to O-succinyl-L-homoserine and takes part in methionine metabolism and sulfur metabolism.
KEGG Pathway
Biosynthesis of amino acids (tma01230 )
Biosynthesis of secondary metabolites (tma01110 )
Cysteine and methionine metabolism (tma00270 )
Metabolic pathways (tma01100 )
Sulfur metabolism (tma00920 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-methionine DME8G1U Discovery agent N.A. Investigative [1]

References

1 Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.