Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DERGEVU)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase domain protein; FMAG_01052
• Gene Name: blaB
• UniProt ID: C3WC84_FUSMR
• INTEDE ID: DME1015
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Fusobacterium mortiferum
  Kingdom: Bacteria
  Phylum: Fusobacteria
  Class: Fusobacteriia
  Order: Fusobacteriales
  Family: Fusobacteriaceae
  Genus: Fusobacterium
  Species: Fusobacterium mortiferum
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MYFCTEIANGVTWIGVNDRKTERFENYIPLPYGVTYNSYFIDDEKTCVIDAVELGSASTF
  LDKIVECLDGRKLDYIVINHVEPDHSSGLKEVIRTFPTVKIVGNAKTLGMLQAFSPDFPV
  ENFVTIKEGDILELGNHKLTFAMIPMVHWPESMVTYDLTDKILFSNDAFGSFGALDGGIF
  DDQVNFEFYQSEMRRYYSNIVGKYGPQVLNAIKKLGGLEIKFICPSHGLIWRKDIAKVVS
  LYETWAKLEPETEGVVIVYGSMYGNTAKMAEIIGRKLNCCGIKEVKIYDASKTDLSFIIS
  EIWKYKGLIIGSCAHNNSVYPKIQPLLHKLENYGLKNRYVGIFGSMMWSGGGVRGIQCFA
  DALKGVEVVGEAVEVKGTPKAEDVTRLEAIAEEMAAKLIAERI
• Function: This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1], [2]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[2]

References

• [1] Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
• [2] Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6.