Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DERI7LO)

• DME Name: AmpC beta-lactamase (ampC)
• Synonyms: Beta-lactamase ampC; Bacterial burkholderia beta-lactamase ampC; ampC; BMULJ_05519
• Gene Name: ampC
• UniProt ID: A0A0H3KQ39_BURM1
• INTEDE ID: DME1192
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Burkholderia multivorans
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Betaproteobacteria
  Order: Burkholderiales
  Family: Burkholderiaceae
  Genus: Burkholderia
  Species: Burkholderia multivorans
  Subspecies: Burkholderia multivorans ATCC 17616
• Tissue Distribution: Primarily distributed in human lung.
• Sequence:
  MRITVTRVVATLLVATAAIATTGRAAELTQAHIRQIVTQQVAPAMKQYAIPGVAIGVIVD
  GKRYVFDYGVMSKDTGKPVTADTLFEIGSVSKTLTATLAADAQEGGELSLSDPVARYVPA
  LNGKPAGALTLLELGTHTAGGLPQQVPDAIHDDATLIGYFDAWRPASVPGTQRVYSNVGI
  GTLGWITAKAMKRDFAELMERRLFPALGMTHTYIDVPDARRADYAQGYTTDGTPIRMKPG
  GLWQPAYGVRTTATDLLRFVQANMGGIDIAPRLQRAIERTHTGYFRAGPLTQDLIWEQYP
  YPVALPTLLEGNASKMLSDAVPAVALTPPLAPQRNVWINKTGSTNGFSTYVAFVPAKRIG
  FVMLANRRVPNEVRVEIAYRILASLGGAR
• Function: This enzyme hydrolyzes beta-lactam.
• KEGG Pathway:
  Two-component system (bmj02020)
  beta-Lactam resistance (bmj01501)

Molecular Interaction Atlas (MIA) of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[1]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]

References

• [1] Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18.