Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEUX61H)

• DME Name: Biphenyl dioxygenase (bphC)
• Synonyms: Biphenyl-2,3-diol 1,2-dioxygenase; 2,3-dihydroxybiphenyl dioxygenase; 23OHBP oxygenase; DHBD; bphC
• Gene Name: bphC
• UniProt ID: BPHC_PSEFK
• INTEDE ID: DME1009
• EC Number:
  EC: 1.13.11.39
  Oxidoreductase
  Oxygen single donor oxidoreductase
  Oxygen single donor oxidoreductase
  EC: 1.13.11.39
• Lineage:
  Species: Pseudomonas furukawaii
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Pseudomonadales
  Family: Pseudomonadaceae
  Genus: Pseudomonas
  Species: Pseudomonas furukawaii
  Subspecies: Pseudomonas furukawaii KF707
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSIRSLGYMGFAVSDVAAWRSFLTQKLGLMEAGTTDNGDLFRIDSRAWRIAVQQGEVDDL
  AFAGYEVADAAGLAQMADKLKQAGIAVTTGDASLARRRGVTGLITFADPFGLPLEIYYGA
  SEVFEKPFLPGAAVSGFLTGEQGLGHFVRCVPDSDKALAFYTDVLGFQLSDVIDMKMGPD
  VTVPVYFLHCNERHHTLAIAAFPLPKRIHHFMLEVASLDDVGFAFDRVDADGLITSTLGR
  HTNDHMVSFYASTPSGVEVEYGWSARTVDRSWVVVRHDSPSMWGHKSVRDKALRATKHEQ
  QPE
• Function: This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls) and contains Fe2+ or Mn2+ .

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[1]

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AUS-131	DMUXO3Z	Hot flushes	GA30	Phase 2	[1]

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavanone	DMNWIYM	Discovery agent	N.A.	Investigative	[1]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[1]

References

• [1] Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28.