Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZWDKE)

DME Name	NADPH-dependent curcumin reductase (curA)
Synonyms	NADPH-dependent curcumin/dihydrocurcumin reductase; b1449; JW5907; curA; yncB
Gene Name	curA
UniProt ID	CURA_ECOLI
INTEDE ID	DME1077
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	946012
EC Number	EC: 1.3.1.- Oxidoreductase CH-CH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.3.1.-
Lineage	Species: Escherichia coli Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli
Tissue Distribution	Primarily distributed in human gut.
Sequence	MGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSD EPSYSPPVDIGGVMVGGTVSRVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHP QNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGV AGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNT SARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMG QWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD
Function	This enzyme catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. And the enzyme also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1]
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References

1	Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.