Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT08HOR5)

DOT Name Superoxide dismutase (SOD2)
Synonyms EC 1.15.1.1
Gene Name SOD2
UniProt ID
Q4ZJI1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
1.15.1.1
Pfam ID
PF02777 ; PF00081
Sequence
RHQQAAGRQAAWLPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNN
LNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAI
KRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLG
IDVWEHAYYLQYKNVRPDYLKAIWNVINWENV
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Paclitaxel DMLB81S Approved Superoxide dismutase (SOD2) increases the Apoptosis ADR of Paclitaxel. [1]
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References

1 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.