Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1JVP79)

DOT Name	Keratin-associated protein 21-2 (KRTAP21-2)
Gene Name	KRTAP21-2
UniProt ID	KR212_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF11759
Sequence	MCCNYYRNCCGGCGYGSGWSSGCGYGCGYGCGYGSGCRYGSGYGTGCGYGCGYGSGCGYG CGYSSSCCGYRPLCYRRCYSSCY
Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Reactome Pathway	Keratinization (R-HSA-6805567 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
THAPSIGARGIN	DMDMQIE	Preclinical	THAPSIGARGIN increases the expression of Keratin-associated protein 21-2 (KRTAP21-2).	[1]
------------------------------------------------------------------------------------

References

1	Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.