Details of the Drug

General Information of Drug (ID: DMDMQIE)

Drug Name
THAPSIGARGIN
Synonyms
thapsigargin; 67526-95-8; UNII-Z96BQ26RZD; Z96BQ26RZD; CHEMBL96926; CHEBI:9516; OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 650.8
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 17
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 12
Chemical Identifiers
Formula
C34H50O12
IUPAC Name
[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
Canonical SMILES
CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
InChI
InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChIKey
IXFPJGBNCFXKPI-FSIHEZPISA-N
Cross-matching ID
PubChem CID
446378
ChEBI ID
CHEBI:9516
CAS Number
67526-95-8
TTD ID
D02KGR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Gene/Protein Processing [2]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Gene/Protein Processing [3]
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [4]
14-3-3 protein eta OTP8NJFJ 1433F_HUMAN Gene/Protein Processing [3]
14-3-3 protein gamma OTYQTMPI 1433G_HUMAN Gene/Protein Processing [3]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) OT6WZPWV KBL_HUMAN Gene/Protein Processing [3]
26S proteasome non-ATPase regulatory subunit 1 (PSMD1) OTW258OV PSMD1_HUMAN Gene/Protein Processing [3]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [3]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) OT7RJON4 HCD2_HUMAN Gene/Protein Processing [3]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) OTCMMMIZ 3HIDH_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -6.4562 -0.6698 -7.041 61.752
ES1 GDSC1 -10.7131 -3.0099 -11.1231 81.8349
NY GDSC1 -10.5622 -3.5035 -10.8709 82.8917
SaOS-2 GDSC1 -9.6745 7.555 -13.6426 64.2939
EW-16 GDSC1 -9.0601 -6.3597 -9.0635 89.9509
ES4 GDSC1 -8.9921 -6.7172 -8.9929 91.1984
HOS GDSC1 -8.9401 -7.1866 -8.9402 92.9242
G-292 clone A141B1 GDSC1 -8.6619 -0.6369 -9.4568 71.6545
NOS-1 [Human HNSCC] GDSC1 -8.6534 -6.754 -8.6536 90.3837
CAL-72 GDSC1 -8.6076 14.4541 -15.701 58.4889
SK-ES-1 GDSC1 -8.559 7.1042 -12.2968 62.0456
ES6 GDSC1 -8.4918 -7.1758 -8.4918 91.2768
EW-13 GDSC1 -8.3547 -2.5503 -8.6587 75.0268
EW-1 GDSC1 -8.0306 -5.6933 -8.0333 83.7102
MHH-ES-1 GDSC1 -7.8111 -6.8184 -7.8111 85.1442
A-673 GDSC1 -7.6469 -7.0077 -7.6469 83.4747
EW-7 GDSC1 -7.2592 -5.8048 -7.2593 78.0628
SK-PN-DW GDSC1 -7.1872 -1.8489 -7.5363 68.1028
H-EMC-SS GDSC1 -6.8526 -3.2243 -6.9435 69.0962
ES8 GDSC1 -6.6711 -3.7659 -6.706 68.852
EW-18 GDSC1 -6.6457 -3.109 -6.7375 67.3082
U2OS GDSC1 -6.5761 -2.3719 -6.7698 65.339
SJSA-1 GDSC1 -6.3908 -0.5334 -7.0098 61.1576
ES7 GDSC1 -6.0514 1.137 -7.2046 57.3494
EW-11 GDSC1 -4.0109 2.3354 -5.5382 42.8852
CHSA0108 GDSC1 -3.1857 4.5196 -5.7234 38.7055
EW-3 GDSC1 -2.9186 6.1977 -6.2816 38.7215
MG-63 GDSC1 -2.733 7.6578 -6.8264 39.0246
TC-71 GDSC1 -1.8791 5.493 -4.9847 30.3768
ES5 GDSC1 -0.3227 11.9105 -6.8762 30.97
EW-24 GDSC1 -0.1433 80.5376 -41.0341 46.7246
HuO-3N1 GDSC1 -0.1255 68.2839 -34.8929 46.1265
CHSA0011 GDSC1 0.8716 9.8526 -4.9306 20.8028
CHSA8926 GDSC1 0.9955 20.2551 -9.9893 33.8735
CAL-78 GDSC1 1.285 12.2103 -5.7852 23.148
HuO9 GDSC1 1.7822 4.2906 -1.8074 1.2295
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -5.2773 -1.4578 -5.5464 53.1818
A4/Fukuda GDSC1 -10.6491 -3.6806 -10.9352 83.4903
RS4;11 GDSC1 -9.1505 -1.9181 -9.6571 75.9067
NALM-6 GDSC1 -9.1382 -7.3142 -9.1383 93.8298
697 GDSC1 -9.039 -7.6797 -9.039 95.0838
SU-DHL-16 GDSC1 -8.9893 -3.0343 -9.2564 78.375
ALL-SIL GDSC1 -8.9656 -6.6107 -8.9668 90.7204
ST486 GDSC1 -8.8757 -6.1776 -8.8796 88.8118
Karpas-620 GDSC1 -8.8587 -7.5906 -8.8587 94.2995
BL-41 GDSC1 -8.813 -7.5725 -8.813 94.0889
Ku812 GDSC1 -8.549 -2.9445 -8.7975 76.7793
SU-DHL-5 GDSC1 -8.4895 -7.8632 -8.4895 93.4323
DB GDSC1 -8.4265 -1.6321 -8.9361 73.0061
P30/OHK GDSC1 -8.4145 -7.1179 -8.4145 90.6646
Mono-Mac-6 GDSC1 -8.4057 -1.0063 -9.0741 71.5607
JJN-3 GDSC1 -8.3786 -5.7909 -8.3829 85.7004
Farage GDSC1 -8.37 -6.9057 -8.37 89.6964
EJM GDSC1 -8.1963 -4.4536 -8.2445 80.197
Ramos.2G6.4C10 GDSC1 -8.1131 -6.8356 -8.1131 87.833
H9 GDSC1 -8.1106 -6.7263 -8.1106 87.5069
A3/Kawakami GDSC1 -8.1008 -7.2394 -8.1008 88.6758
SIG-M5 GDSC1 -8.0701 -7.1513 -8.0701 88.2239
Daudi GDSC1 -8.0173 -6.027 -8.0181 84.7427
BC-3 GDSC1 -7.9727 -3.5616 -8.0915 76.3928
Karpas-231 GDSC1 -7.8772 -5.4588 -7.8813 82.0674
L-363 GDSC1 -7.8609 -6.6052 -7.8609 85.2236
MC116 GDSC1 -7.8479 -6.539 -7.8479 84.9659
KOPN-8 GDSC1 -7.8291 -6.069 -7.8294 83.6234
KMS-12-BM GDSC1 -7.8025 -6.7443 -7.8025 84.944
MOLP-8 GDSC1 -7.7494 -4.8729 -7.7641 79.4408
RPMI-8226 GDSC1 -7.6461 -6.3966 -7.6461 82.8378
OCI-AML-5 GDSC1 -7.6258 1.2183 -8.9291 64.8579
WIL2 NS GDSC1 -7.6107 0.2734 -8.5902 66.1849
RPMI-8402 GDSC1 -7.5379 -4.3315 -7.5699 76.5317
AMO1 GDSC1 -7.5028 -3.7605 -7.5747 74.6471
SU-DHL-8 GDSC1 -7.4918 -5.03 -7.4984 78.2874
CTV-1 GDSC1 -7.4711 -5.2328 -7.4745 78.6957
SU-DHL-6 GDSC1 -7.4601 -6.4093 -7.4601 80.9272
CA46 GDSC1 -7.3609 1.4559 -8.7292 63.4831
KM-H2 GDSC1 -7.3025 -6.2968 -7.3025 79.0599
SU-DHL-4 GDSC1 -7.2533 -6.3594 -7.2533 78.5194
HT GDSC1 -7.2028 -4.5982 -7.215 75.0199
Jiyoye GDSC1 -7.0986 -3.7215 -7.1544 72.0196
BE-13 GDSC1 -7.0546 -4.9265 -7.0582 74.5571
DND-41 GDSC1 -7.0515 -4.3064 -7.0706 73.1363
P31/FUJ GDSC1 -7.0254 -6.019 -7.0254 75.6629
KE-37 GDSC1 -7.012 -4.2102 -7.0341 72.5984
U266B1 GDSC1 -6.9085 -5.8492 -6.9085 74.2001
Karpas-45 GDSC1 -6.8692 -4.2258 -6.8868 71.4775
TUR GDSC1 -6.8511 -1.6308 -7.22 65.7444
P32/ISH GDSC1 -6.8363 -5.0114 -6.8378 72.6206
OPM-2 GDSC1 -6.8295 -4.4183 -6.8399 71.5311
BV-173 GDSC1 -6.7482 -2.471 -6.9383 66.74
KY821 GDSC1 -6.7367 -5.2129 -6.7371 71.7974
DEL GDSC1 -6.6837 -4.9175 -6.685 70.9115
SUP-M2 GDSC1 -6.6825 -5.0449 -6.6832 71.038
Reh GDSC1 -6.6767 -3.4186 -6.7384 68.1882
WSU-NHL GDSC1 -6.6125 -4.669 -6.6155 69.8552
MOLT-16 GDSC1 -6.6035 -4.4076 -6.6106 69.393
NKM-1 GDSC1 -6.5985 2.3201 -8.2424 59.2156
BALL-1 GDSC1 -6.5889 -4.2816 -6.5988 69.0522
VL51 GDSC1 -6.5839 -1.1724 -7.0418 63.3014
MEG-01 GDSC1 -6.5819 -3.7649 -6.6136 68.0814
NK-92MI GDSC1 -6.5737 -4.3457 -6.5817 69.0042
OCI-Ly19 GDSC1 -6.558 -3.2096 -6.6338 66.8144
DoHH2 GDSC1 -6.5534 -4.9064 -6.5542 69.4824
MV4-11 GDSC1 -6.5444 -5.2823 -6.5445 69.6285
LP-1 GDSC1 -6.4987 -2.5335 -6.6595 65.0677
EB2 GDSC1 -6.4802 -1.0885 -6.9507 62.5092
JVM-3 GDSC1 -6.3875 -5.0881 -6.3876 67.6784
NB4 GDSC1 -6.3528 -4.8326 -6.3534 67.1456
YT GDSC1 -6.2565 -4.2029 -6.263 65.5482
KCL-22 GDSC1 -6.1937 -1.6003 -6.5112 61.2548
MHH-PREB-1 GDSC1 -6.1435 -1.6012 -6.4564 60.875
NU-DUL-1 GDSC1 -6.1039 -4.8585 -6.104 64.1817
EoL-1 GDSC1 -6.0647 -2.8593 -6.1507 61.9424
TK [Human B-cell lymphoma] GDSC1 -6.054 -3.044 -6.1192 62.0836
OCI-AML-2 GDSC1 -6.0182 -2.5515 -6.1416 61.1097
ML-2 GDSC1 -6.0101 -4.6659 -6.0104 62.9952
CTB-1 GDSC1 -5.8469 2.5534 -7.5418 55.2699
Namalwa GDSC1 -5.8224 -2.1623 -5.9938 58.8689
ALL-PO GDSC1 -5.8012 -2.8918 -5.8682 59.4153
P12-Ichikawa GDSC1 -5.716 -2.0189 -5.905 57.745
GR-ST GDSC1 -5.6883 2.0978 -7.1896 54.6056
JURL-MK1 GDSC1 -5.492 -1.2557 -5.8293 55.0973
LAMA-84 GDSC1 -5.4671 -2.577 -5.5502 55.6825
SUP-B15 GDSC1 -5.3501 0.4857 -6.2128 53.0564
Karpas-422 GDSC1 -5.2439 -2.31 -5.3482 53.1434
MOLM-13 GDSC1 -5.2429 -3.1779 -5.2625 53.3655
OCI-M1 GDSC1 -5.1712 -3.4087 -5.1797 52.5331
THP-1 GDSC1 -5.1528 8.277 -9.4143 50.7388
PF-382 GDSC1 -5.0514 0.3664 -5.8481 50.7169
Sc-1 GDSC1 -5.0344 1.0139 -6.0689 50.5326
BC-1 GDSC1 -4.9172 0.7216 -5.8331 49.6037
CCRF-CEM GDSC1 -4.8341 0.1478 -5.5365 48.8354
ATN-1 GDSC1 -4.7961 -0.8838 -5.1686 48.2855
Loucy GDSC1 -4.7149 -2.2645 -4.7897 47.0348
MOLT-4 GDSC1 -4.6242 -0.7423 -5.0215 46.5377
CESS GDSC1 -4.6215 5.8893 -7.7704 48.2995
Karpas-299 GDSC1 -4.5219 -0.192 -5.0825 45.7468
HEL GDSC1 -4.4593 -1.2033 -4.7162 44.4793
RPMI-6666 GDSC1 -4.3733 0.4815 -5.1602 44.692
Raji GDSC1 -4.3048 6.2103 -7.611 46.7395
SK-MM-2 GDSC1 -4.2299 1.6066 -5.4538 44.1634
SCC-3 GDSC1 -4.2142 0.101 -4.8504 42.8091
MLMA GDSC1 -4.1641 -0.1867 -4.6962 42.0074
SUP-T1 GDSC1 -4.1407 -0.9817 -4.4263 40.9441
VAL GDSC1 -4.1389 5.4238 -7.0781 45.5691
LC4-1 GDSC1 -4.0522 2.1396 -5.4955 43.0666
ROS-50 GDSC1 -4.0234 6.052 -7.2627 45.1792
EM-2 GDSC1 -3.9723 0.1199 -4.5964 40.2651
SUP-HD1 GDSC1 -3.9619 9.0756 -8.6594 45.9321
KG-1 GDSC1 -3.8653 1.7684 -5.1423 41.0994
GDM-1 GDSC1 -3.7571 -0.8504 -4.0443 36.4648
MN-60 GDSC1 -3.6966 5.3994 -6.636 42.9254
L-540 GDSC1 -3.6628 4.2094 -6.041 41.8147
KMOE-2 GDSC1 -3.6055 0.6217 -4.3947 36.9923
JSC-1 GDSC1 -3.4977 0.639 -4.2874 35.8431
ARH-77 GDSC1 -3.4707 0.7242 -4.2932 35.6961
RC-K8 GDSC1 -3.2932 1.6068 -4.4822 35.3945
EHEB GDSC1 -3.2711 0.8462 -4.1335 33.726
HH [Human lymphoma] GDSC1 -3.1244 2.1567 -4.5567 34.715
SU-DHL-1 GDSC1 -3.0978 3.4077 -5.1105 36.5492
HC-1 GDSC1 -2.8761 1.6365 -4.0707 31.1256
OCI-AML-3 GDSC1 -2.6469 2.3341 -4.164 30.3599
PL-21 GDSC1 -2.0987 2.8954 -3.9063 26.2958
U-698-M GDSC1 -1.9783 71.3372 -37.9645 47.7659
HDLM-2 GDSC1 -1.919 7.4339 -5.9842 33.8709
Granta-519 GDSC1 -1.8439 4.1727 -4.2992 27.202
K-562 GDSC1 -1.8166 4.2361 -4.3058 27.116
HAL-01 GDSC1 -1.7278 -0.1533 -2.104 12.1813
ME1 GDSC1 -1.3212 2.7889 -3.1469 18.1442
QIMR-WIL GDSC1 -1.2774 12.0428 -7.7315 35.7128
L-1236 GDSC1 -1.2707 4.8541 -4.1335 23.9721
RPMI-8866 GDSC1 -0.9156 6.0723 -4.4431 24.1997
MY-M12 GDSC1 -0.4818 73.638 -37.8651 46.6856
HL-60 GDSC1 -0.329 5.1748 -3.5228 16.9947
DG-75 GDSC1 -0.2037 4.7526 -3.2174 14.6077
RL GDSC1 0.0729 3.6882 -2.4944 8.6884
SR GDSC1 0.5283 6.8136 -3.6915 15.3815
IM-9 GDSC1 0.5726 7.2069 -3.8518 16.1882
NOMO-1 GDSC1 0.5754 3.12 -1.9122 3.3907
JVM-2 GDSC1 0.7449 4.586 -2.4786 6.888
L-428 GDSC1 0.9685 2.959 -1.6458 1.2654
Hs 445 GDSC1 0.9715 2.4946 -1.4671 0.5141
WSU-DLCL2 GDSC1 1.3456 2.3851 -1.2955 0.0445
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -7.7591 -6.042 -7.7594 83.0278
KYSE-50 GDSC1 -7.6327 -5.9884 -7.6329 81.8815
KYSE-220 GDSC1 -7.3829 -3.6918 -7.455 73.7582
TE-12 GDSC1 -7.3229 -5.9038 -7.3229 78.8534
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -1.0419 12.6987 -7.8616 35.2629
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-7 GDSC1 -8.6521 -7.8589 -8.6521 94.4987
NB69 GDSC1 -8.3005 -6.3562 -8.301 87.4142
TGW GDSC1 -7.6283 -5.9756 -7.6285 81.815
SJNB-6 GDSC1 -7.5515 2.5556 -9.348 62.9464
CHP-212 GDSC1 -7.3518 -5.9897 -7.3518 79.2721
SJNB-13 GDSC1 -7.3492 -5.9741 -7.3493 79.2235
SJNB-14 GDSC1 -7.3271 -4.6153 -7.3413 75.9778
GI-ME-N GDSC1 -6.9803 -0.1725 -7.7622 63.9852
KP-N-YS GDSC1 -6.8617 -5.0442 -6.863 72.9254
NB(TU)1 GDSC1 -6.7279 -4.8608 -6.7298 71.3015
SJNB-12 GDSC1 -6.4416 -5.3162 -6.4416 68.4011
SK-N-SH GDSC1 -6.4197 -4.7959 -6.4206 67.8895
SK-N-MC-IXC GDSC1 -6.3802 -5.5261 -6.3802 67.674
IMR-5 GDSC1 -5.7902 -1.999 -5.989 58.4053
SK-N-BE(2)-M17 GDSC1 -5.6966 -2.7415 -5.7741 58.2089
NH-12 GDSC1 -5.5286 -3.7853 -5.5337 56.9377
NB1 GDSC1 -5.2392 2.537 -6.8979 51.7484
MHH-NB-11 GDSC1 -5.167 -3.1174 -5.1875 52.4469
Kelly GDSC1 -5.0977 -2.6727 -5.1488 51.5634
KP-N-YN GDSC1 -5.0149 -1.2348 -5.3142 50.5045
CHP-126 GDSC1 -4.8753 0.3556 -5.6543 49.2244
SiMa GDSC1 -4.8203 -2.2135 -4.909 48.3023
SK-N-AS GDSC1 -4.4 -1.2935 -4.6295 43.7341
SK-N-DZ GDSC1 -4.3098 -0.9754 -4.6126 42.9243
SJNB-10 GDSC1 -3.9185 -0.8735 -4.2139 38.4051
SJNB-5 GDSC1 -3.8421 0.1827 -4.4792 38.9249
SK-N-FI GDSC1 -3.3081 -1.0223 -3.5068 30.5235
GOTO GDSC1 -1.36 17.3984 -10.4784 39.7738
LA-N-6 GDSC1 -0.2896 7.3765 -4.5877 22.7237
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -8.219 -6.1126 -8.22 86.1458
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1937 GDSC1 -12.2879 -1.7934 -13.1062 81.173
HCC1395 GDSC1 -9.9505 4.0725 -12.4928 68.0819
MCF-7 GDSC1 -9.8109 -7.5217 -9.8114 95.2147
MDA-MB-231 GDSC1 -9.1652 -0.3052 -10.1028 72.4932
MDA-MB-361 GDSC1 -8.7828 -5.8479 -8.7905 87.2921
OCUB-M GDSC1 -8.5594 -6.435 -8.5602 88.8229
BT-549 GDSC1 -8.3896 -7.5055 -8.3896 91.7209
EFM-192A GDSC1 -8.251 -7.369 -8.251 90.284
CAL-51 GDSC1 -8.0825 -7.0646 -8.0825 88.1563
MDA-MB-468 GDSC1 -8.0696 -6.8572 -8.0696 87.5571
MDA-MB-330 GDSC1 -7.8923 -5.9387 -7.8931 83.679
HCC1569 GDSC1 -7.8403 0.6515 -8.9648 66.507
MDA-MB-436 GDSC1 -7.6576 -2.9189 -7.8432 73.1012
JIMT-1 GDSC1 -7.638 -3.3651 -7.76 74.2363
HCC2157 GDSC1 -7.6103 -4.7829 -7.6249 78.3357
HCC38 GDSC1 -7.5472 -3.2114 -7.6829 73.3392
HCC1806 GDSC1 -7.5303 -0.7648 -8.1857 67.6274
HCC1500 GDSC1 -7.4936 2.4118 -9.2306 62.8867
DU4475 GDSC1 -7.4639 -5.3021 -7.4665 78.8247
HCC1428 GDSC1 -7.2331 -5.1232 -7.2359 76.5306
CAL-85-1 GDSC1 -7.1537 1.5891 -8.5554 62.4491
AU565 GDSC1 -7.1044 -5.774 -7.1045 76.391
CAMA-1 GDSC1 -6.5435 -0.4854 -7.1906 62.0297
ZR-75-30 GDSC1 -5.9324 -1.0384 -6.3663 58.5765
HCC70 GDSC1 -5.7879 -3.5458 -5.8058 59.8348
HCC1954 GDSC1 -5.3027 -0.2322 -5.9177 52.9439
MRK-nu-1 GDSC1 -5.2459 3.991 -7.532 51.55
HCC202 GDSC1 -4.9185 18.0344 -13.9323 49.8883
CAL-120 GDSC1 -4.4415 17.0071 -12.9911 48.6761
UACC-893 GDSC1 -4.1968 2.8076 -5.9365 44.6708
HCC2218 GDSC1 -4.0377 2.5678 -5.6679 43.2849
COLO 824 GDSC1 -3.3833 2.5842 -5.0115 37.8082
BT-474 GDSC1 -3.3275 1.9242 -4.6576 36.2784
Evsa-T GDSC1 -2.9968 5.8543 -6.1876 38.8692
HCC1599 GDSC1 -2.3244 7.7072 -6.4808 36.7031
MDA-MB-175-VII GDSC1 -1.5293 6.3889 -5.1227 29.4976
HCC1187 GDSC1 -0.8548 7.6726 -5.1929 27.2801
HDQ-P1 GDSC1 -0.7011 28.1192 -15.2883 42.0027
MDA-MB-415 GDSC1 -0.0063 20.703 -11.0114 37.318
BT-20 GDSC1 0.0152 22.1015 -11.6925 38.008
Hs 578T GDSC1 0.1234 49.6108 -25.3522 44.3895
EFM-19 GDSC1 0.1337 29.0372 -15.0612 40.4986
MFM-223 GDSC1 0.6528 4.4246 -2.4611 6.9793
MDA-MB-157 GDSC1 0.9036 28.2691 -14.0561 38.525
HCC1419 GDSC1 0.9237 6.7308 -3.3761 12.3832
UACC-812 GDSC1 0.9303 2.8956 -1.6379 1.2674
CAL-148 GDSC1 1.0053 10.0006 -4.9057 20.3261
T-47D GDSC1 1.0126 10.0403 -4.9198 20.3691
MDA-MB-453 GDSC1 1.0993 15.128 -7.3632 28.456
BT-483 GDSC1 1.2624 5.0161 -2.3673 5.0734
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KALS-1 GDSC1 -10.9047 3.0883 -13.1379 71.1953
A-172 GDSC1 -9.8246 -6.5302 -9.8327 91.6694
YH-13 GDSC1 -9.563 17.6975 -18.164 59.0831
SF268 GDSC1 -8.571 -6.0068 -8.5745 87.2349
GI-1 GDSC1 -8.3064 -7.4505 -8.3064 90.9349
Hs 683 GDSC1 -8.304 2.7834 -10.2383 65.2483
8-MG-BA GDSC1 -8.1651 -5.9492 -8.1667 85.2997
SF295 GDSC1 -8.1179 -6.7052 -8.1179 87.4963
MOG-G-UVW GDSC1 -7.9874 4.5604 -10.6172 62.4554
H4 GDSC1 -7.8143 -5.7479 -7.8156 82.5852
D283 Med GDSC1 -7.7155 -5.0569 -7.7246 79.8245
D-566MG GDSC1 -7.6757 1.5907 -9.1171 64.5569
ONS-76 GDSC1 -7.6078 -5.9193 -7.6081 81.5118
KNS-42 GDSC1 -7.6012 2.3606 -9.3257 63.3467
KS-1 [Human Krukenberg tumour] GDSC1 -7.5973 -3.9038 -7.6611 75.5901
U-251MG GDSC1 -7.5722 -6.5151 -7.5722 82.2572
Daoy GDSC1 -7.5019 -5.7782 -7.5023 80.293
GaMG GDSC1 -7.4704 -5.2924 -7.4732 78.8492
T98G GDSC1 -7.3366 -3.3843 -7.4379 72.6434
SK-MG-1 GDSC1 -7.2855 -6.0478 -7.2855 78.6489
YKG-1 GDSC1 -7.0925 -5.2943 -7.0934 75.602
DBTRG-05MG GDSC1 -6.977 -5.1988 -6.978 74.3151
D-423MG GDSC1 -6.949 -5.7753 -6.949 74.6386
SW1783 GDSC1 -6.8851 -4.8121 -6.8887 72.7811
M059J GDSC1 -6.85 -3.724 -6.8948 70.2111
KINGS-1 GDSC1 -6.6689 -2.8334 -6.7971 66.9194
SF539 GDSC1 -6.6074 -3.9359 -6.6306 68.6247
LN-18 GDSC1 -6.5728 -5.7264 -6.5728 70.078
NMC-G1 GDSC1 -6.2009 7.2335 -9.9608 54.8627
PFSK-1 GDSC1 -6.1502 -3.1767 -6.2076 63.1774
D-542MG GDSC1 -6.1082 1.2642 -7.3129 57.5769
D-263MG GDSC1 -6.0967 187.6479 -99.5817 50.3206
AM-38 GDSC1 -5.9343 -2.601 -6.0449 60.3995
Onda 11 GDSC1 -5.5178 2.8836 -7.3343 53.308
SNB-75 GDSC1 -5.2993 6.9294 -8.9242 51.4366
U-118MG GDSC1 -5.0992 3.0147 -6.9551 50.824
LN-229 GDSC1 -5.0635 -0.5708 -5.5515 50.9187
SF126 GDSC1 -4.4189 1.4817 -5.6007 45.6883
DK-MG GDSC1 -3.3664 18.0393 -12.5362 45.9611
GB-1 GDSC1 -2.88 3.3914 -4.8907 34.6655
U-87MG ATCC GDSC1 -2.699 1.8714 -4.0002 29.8018
Becker GDSC1 -2.617 7.9428 -6.8613 38.6324
D-502MG GDSC1 -1.9307 5.085 -4.8287 29.9686
LNZTA3WT4 GDSC1 -1.6708 5.6846 -4.8953 29.1576
SW1088 GDSC1 -1.6661 7.283 -5.6874 32.0098
CAS-1 GDSC1 -0.5601 67.0958 -34.6591 46.434
Onda 10 GDSC1 -0.4236 9.2793 -5.6438 27.5259
MOG-G-CCM GDSC1 -0.4197 40.6547 -21.3227 43.9727
LN-405 GDSC1 -0.1642 7.5719 -4.5864 22.3082
42-MG-BA GDSC1 0.0057 99.5091 -50.3959 47.26
KNS-81-FD GDSC1 1.2135 13.25 -6.3493 25.2652
D-392MG GDSC1 1.5419 4.5732 -2.0298 2.5868
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 -9.4679 0.3679 -10.6401 72.0692
ETK-1 GDSC1 -8.8833 -2.5615 -9.2289 76.7767
TGBC24TKB GDSC1 -8.7408 -7.3633 -8.7408 93.0366
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 -8.7253 -2.3792 -9.0942 75.8201
ESS-1 GDSC1 -8.7117 -0.3627 -9.5912 71.2771
AN3-CA GDSC1 -8.346 -3.494 -8.4969 77.6817
MFE-296 GDSC1 -7.7989 -4.4926 -7.8306 78.4888
MFE-280 GDSC1 -4.595 -1.8489 -4.725 45.7324
KLE GDSC1 -3.4541 9.7315 -8.5074 43.9544
EN GDSC1 -0.2104 139.1081 -70.3742 48.1265
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -12.5068 -5.0097 -12.731 88.4911
BFTC-909 GDSC1 -7.8135 2.3948 -9.5656 64.0749
BB65-RCC GDSC1 -7.6616 -5.2229 -7.6669 79.9972
VMRC-RCW GDSC1 -7.3196 -4.5473 -7.3359 75.7394
LB1047-RCC GDSC1 -7.249 -4.9875 -7.2536 76.3462
SW13 GDSC1 -6.5971 -4.5293 -6.6019 69.5084
SN12C GDSC1 -5.9144 -3.5984 -5.9335 61.2685
VMRC-RCZ GDSC1 -5.8047 -0.7683 -6.3019 57.327
769-P GDSC1 -5.6609 -3.9152 -5.6652 58.5624
ACHN GDSC1 -5.6422 -2.4952 -5.7477 57.4492
OS-RC-2 GDSC1 -5.2714 -1.4256 -5.5475 53.1121
TK-10 GDSC1 -5.1669 1.1944 -6.2796 51.5044
LB996-RCC GDSC1 -4.9254 -1.1603 -5.2355 49.5846
UO-31 GDSC1 -4.5978 -2.1941 -4.6741 45.6356
LB2241-RCC GDSC1 -3.7021 -0.8219 -3.9925 35.826
Caki-1 GDSC1 -2.9187 -0.4037 -3.2733 26.7267
HA7-RCC GDSC1 -2.9165 1.5089 -4.0543 31.267
SW156 GDSC1 -1.5803 4.8926 -4.4216 26.6797
A-704 GDSC1 -0.9923 33.9375 -18.4395 43.8157
RXF 393L GDSC1 0.0762 14.8679 -8.0319 32.5511
RCC10RGB GDSC1 0.5486 6.5163 -3.5322 14.3634
A-498 GDSC1 0.5756 11.4758 -5.9533 25.6372
CAL-54 GDSC1 0.7653 9.2377 -4.7065 20.077
KMRC-1 GDSC1 1.5347 7.7212 -3.4441 11.2936
KMRC-20 GDSC1 2.1494 9.8821 -4.0653 13.3666
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2998 GDSC1 -8.4682 -7.4492 -8.4682 92.0751
SW620 GDSC1 -8.3286 -7.4819 -8.3286 91.1919
SW48 GDSC1 -8.3036 -7.2468 -8.3036 90.3698
COLO205 GDSC1 -7.884 -7.0709 -7.884 86.2356
HT-29 GDSC1 -7.838 -6.7376 -7.838 85.2767
LoVo GDSC1 -7.5229 -6.3173 -7.5229 81.4868
HCT 116 GDSC1 -7.3219 -6.7588 -7.3219 79.4462
LS180 GDSC1 -7.207 -6.0925 -7.207 77.8205
RKO GDSC1 -6.9821 -3.5038 -7.0513 70.6698
SNU-C2B GDSC1 -6.8629 -5.1672 -6.8636 73.106
KM12 GDSC1 -6.7906 -5.77 -6.7906 72.757
LS123 GDSC1 -6.6989 12.7526 -13.039 54.7982
SW837 GDSC1 -6.5867 1.7951 -8.0258 59.6345
CaR-1 GDSC1 -6.5391 -0.3512 -7.2265 61.8189
T84 GDSC1 -6.2447 -2.2668 -6.4309 62.6348
LS411N GDSC1 -6.1235 -5.087 -6.1236 64.4578
SW1417 GDSC1 -6.0417 11.3218 -11.7226 53.3279
C2BBe1 GDSC1 -5.8704 -1.3263 -6.2243 58.3919
SW626 GDSC1 -5.8387 -1.4692 -6.1553 58.2809
LS1034 GDSC1 -5.0644 -1.2983 -5.3525 51.0148
GP5d GDSC1 -4.5835 1.3898 -5.7371 47.0093
COLO 320HSR GDSC1 -4.5639 -1.9478 -4.6745 45.3192
RCM-1 [Human ESC] GDSC1 -4.1856 5.487 -7.1536 45.8601
NCI-H747 GDSC1 -3.4321 4.0297 -5.7303 39.9789
LS513 GDSC1 -2.7228 1.9177 -4.0453 30.1627
HCT 15 GDSC1 -2.6669 8.4998 -7.1815 39.3962
HT-55 GDSC1 -2.2426 0.8685 -3.0841 21.837
MDST8 GDSC1 -1.3073 4.4455 -3.9611 23.1789
CCK-81 GDSC1 -0.8783 6.1786 -4.4654 24.1725
SNU-C1 GDSC1 -0.8135 2.7331 -2.6898 12.9266
HT115 GDSC1 -0.733 4.0879 -3.3013 16.9576
SW1463 GDSC1 -0.3189 4.4487 -3.1546 14.5577
COLO 678 GDSC1 0.1954 11.8653 -6.4412 28.2699
SW948 GDSC1 0.5894 6.0406 -3.2728 12.6229
NCI-H716 GDSC1 0.9241 9.326 -4.6343 19.2948
CL-11 GDSC1 1.01 4.5757 -2.3146 5.2158
CW-2 GDSC1 2.2509 3.9792 -1.5176 0.1634
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.3684 8.954 -5.437 26.5916
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -11.0248 -7.8411 -11.0276 96.0999
SNU-423 GDSC1 -10.1013 3.7766 -12.5382 68.7447
SNU-387 GDSC1 -9.9439 1.5832 -11.5618 71.2624
Huh-7 GDSC1 -8.6359 -6.6094 -8.6363 89.7666
JHH-1 GDSC1 -8.5914 2.4647 -10.4241 66.5109
Hep 3B2.1-7 GDSC1 -8.448 -6.9206 -8.448 90.1517
JHH-6 GDSC1 -8.3801 -6.7693 -8.3801 89.2755
SK-HEP-1 GDSC1 -7.857 -7.0991 -7.857 85.97
HLE GDSC1 -7.5943 -3.7902 -7.668 75.2381
JHH-7 GDSC1 -7.1422 -5.906 -7.1422 76.9351
JHH-4 GDSC1 -6.2481 -5.1131 -6.2481 65.9957
SNU-449 GDSC1 -6.1765 0.5306 -7.1214 58.6287
Hep-G2/C3A GDSC1 -6.079 0.087 -6.8653 58.4519
HuH-1 GDSC1 -4.7282 3.2599 -6.6797 48.5135
JHH-2 GDSC1 1.5004 9.0752 -4.1094 15.1343
SNU-475 GDSC1 1.6293 11.8894 -5.38 20.7199
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LXF 289 GDSC1 -11.0349 -7.0833 -11.0482 93.9017
NCI-H2369 GDSC1 -10.95 -2.1728 -11.5576 80.2073
SK-MES-1 GDSC1 -10.7011 -8.5101 -10.7012 97.9856
NCI-H2342 GDSC1 -10.4729 -6.2288 -10.5009 91.0664
CAL-12T GDSC1 -10.3562 -3.6955 -10.6183 83.1106
NCI-H647 GDSC1 -10.1967 3.6791 -12.6024 69.0619
HCC44 GDSC1 -10.0325 -7.204 -10.0348 94.184
HOP-92 GDSC1 -9.8822 3.6854 -12.2695 68.3675
HOP-62 GDSC1 -9.6208 -6.5035 -9.6272 91.3727
NCI-H2869 GDSC1 -9.3107 -1.9582 -9.8223 76.4266
SK-LU-1 GDSC1 -9.1572 -2.1426 -9.6137 76.4724
RERF-LC-MS GDSC1 -9.1324 0.5059 -10.3196 70.9452
NCI-H847 GDSC1 -8.8415 -7.3878 -8.8415 93.4544
DMS 273 GDSC1 -8.824 -7.8531 -8.824 95.2144
NCI-H1568 GDSC1 -8.6911 -1.0058 -9.3858 72.5008
SW1271 GDSC1 -8.6184 244.5711 -130.1683 50.7923
ABC-1 GDSC1 -8.5871 -7.0742 -8.5872 91.3464
NCI-H520 GDSC1 -8.4703 -7.6256 -8.4703 92.6369
ChaGo-K-1 GDSC1 -8.392 4.6983 -11.0983 63.5277
NCI-H2405 GDSC1 -8.3646 -6.9547 -8.3646 89.8335
Lu-135 GDSC1 -8.3125 -7.0993 -8.3125 89.9896
NCI-H1915 GDSC1 -8.2813 2.1516 -9.9745 65.9489
NCI-H1299 GDSC1 -8.244 -4.9433 -8.2674 82.0835
NCI-H1648 GDSC1 -8.2327 -7.1338 -8.2327 89.5379
NCI-H1792 GDSC1 -8.2307 0.7073 -9.4069 67.8337
LCLC-97TM1 GDSC1 -8.2307 -6.8592 -8.2307 88.7164
IA-LM GDSC1 -8.1227 -4.5037 -8.1649 80.0582
LCLC-103H GDSC1 -8.0143 -5.7594 -8.0164 83.8428
NCI-H1975 GDSC1 -8.0131 -4.4939 -8.0519 79.5398
NCI-H358 GDSC1 -8.0057 -6.7511 -8.0057 86.7804
HCC15 GDSC1 -8.0038 3.574 -10.2307 63.4369
NCI-H2009 GDSC1 -7.9936 -5.8901 -7.9948 84.1561
Lu-99A GDSC1 -7.951 -6.787 -7.951 86.4055
NCI-H810 GDSC1 -7.856 -2.4442 -8.1393 72.7705
SBC-5 GDSC1 -7.8067 -6.8925 -7.8067 85.1997
NCI-H2122 GDSC1 -7.7754 -7.0069 -7.7754 84.977
NCI-H3122 GDSC1 -7.7437 -4.7243 -7.7633 78.9338
NCI-H2087 GDSC1 -7.7415 -6.5858 -7.7415 84.0849
LC-2/ad GDSC1 -7.6885 -5.6064 -7.6901 81.3081
NCI-H2170 GDSC1 -7.5894 -6.9173 -7.5894 82.7532
NCI-H1734 GDSC1 -7.5655 1.9009 -9.1133 63.7494
NCI-H2030 GDSC1 -7.5262 -0.5353 -8.2475 67.1887
A-427 GDSC1 -7.521 -3.8955 -7.5819 75.1416
HCC78 GDSC1 -7.4647 1.7429 -8.9463 63.5487
NCI-H650 GDSC1 -7.4333 7.5542 -11.3469 58.706
LB647-SCLC GDSC1 -7.4285 -5.0344 -7.4342 77.8471
NCI-H64 GDSC1 -7.3917 -6.0358 -7.3917 79.7447
NCI-H522 GDSC1 -7.3892 119.4257 -66.5947 51.0491
NCI-H1355 GDSC1 -7.3613 -2.5462 -7.5862 70.6299
NCI-H2804 GDSC1 -7.33 1.4922 -8.7092 63.3104
NCI-H460 GDSC1 -7.3102 -6.5067 -7.3102 79.2556
Calu-6 GDSC1 -7.2691 -5.1775 -7.2717 76.9571
LK-2 GDSC1 -7.2619 -6.0718 -7.2619 78.4162
NCI-H1437 GDSC1 -7.2275 -5.4269 -7.2283 77.1165
NCI-H2228 GDSC1 -7.21 -5.2209 -7.2119 76.5443
NCI-H727 GDSC1 -7.2009 -1.994 -7.5197 68.4887
NCI-H2085 GDSC1 -7.2003 1.2277 -8.4735 63.0879
COR-L105 GDSC1 -7.1573 -3.0909 -7.2833 70.8052
IST-SL2 GDSC1 -7.1548 -4.2323 -7.18 73.7277
COR-L23 GDSC1 -7.116 -6.1776 -7.116 76.8076
NCI-H441 GDSC1 -7.0742 -6.1404 -7.0742 76.2941
SBC-3 GDSC1 -6.9856 -4.7405 -6.9912 73.5646
NCI-H1435 GDSC1 -6.9175 -4.1032 -6.9419 71.6027
NCI-H1770 GDSC1 -6.9141 -4.8339 -6.9177 73.0935
NCI-H2135 GDSC1 -6.8818 -3.9056 -6.9157 70.8703
NCI-H211 GDSC1 -6.8671 -4.6596 -6.8727 72.3356
NCI-H226 GDSC1 -6.8203 -5.0721 -6.8213 72.5383
NCI-H2110 GDSC1 -6.7971 -5.1708 -6.7977 72.4139
CPC-N GDSC1 -6.6694 -4.3906 -6.6779 70.0041
UMC-11 GDSC1 -6.655 -2.5802 -6.82 66.309
PC-14 GDSC1 -6.6054 1.3346 -7.8726 60.1809
NCI-H1703 GDSC1 -6.5823 -4.6451 -6.5853 69.5107
NCI-H838 GDSC1 -6.5803 -5.7883 -6.5803 70.175
NCI-H2347 GDSC1 -6.5709 -1.8932 -6.8569 64.4291
HCC33 GDSC1 -6.5315 -1.3316 -6.944 63.2199
NCI-H2731 GDSC1 -6.5054 0.0621 -7.3203 61.0852
NCI-H1944 GDSC1 -6.3698 -4.9483 -6.3701 67.4074
NCI-H2591 GDSC1 -6.3406 -3.0804 -6.4178 64.7548
NCI-H2461 GDSC1 -6.3284 -4.397 -6.3324 66.524
NCI-H2171 GDSC1 -6.2953 -4.7958 -6.2959 66.4541
NCI-H2373 GDSC1 -6.2312 5.7049 -9.2982 55.5519
NCI-H292 GDSC1 -6.2256 -4.4901 -6.2276 65.4577
NCI-H1781 GDSC1 -6.2182 -4.7143 -6.2188 65.5057
LC-1/sq GDSC1 -6.1268 12.5389 -12.3866 53.35
A-549 GDSC1 -6.1027 -2.8692 -6.1897 62.3062
LOU-NH91 GDSC1 -6.088 1.0275 -7.2035 57.6537
BEN GDSC1 -5.9769 -2.2816 -6.1397 60.3964
EPLC-272H GDSC1 -5.7467 -3.7196 -5.757 59.479
NCI-H1581 GDSC1 -5.7253 -3.8161 -5.7326 59.282
NCI-H290 GDSC1 -5.6963 -4.4439 -5.6966 59.1101
NCI-H661 GDSC1 -5.6836 -1.8675 -5.8992 57.3073
EBC-1 GDSC1 -5.6713 -4.1498 -5.6728 58.7541
NCI-H2722 GDSC1 -5.667 30.7866 -20.9119 51.0513
Lu-65 GDSC1 -5.6565 0.1208 -6.418 55.5194
NCI-H209 GDSC1 -5.6435 -1.6454 -5.9025 56.7504
NCI-H82 GDSC1 -5.6397 -4.5507 -5.6398 58.4174
Ms-1 GDSC1 -5.4886 -4.0774 -5.4897 56.5067
COLO 668 GDSC1 -5.3938 -1.692 -5.621 54.4311
NCI-H2595 GDSC1 -5.2296 -2.8971 -5.2672 53.1476
NCI-H1048 GDSC1 -5.2067 -1.5551 -5.4474 52.5123
IST-SL1 GDSC1 -5.1594 -1.9353 -5.3188 52.1218
HARA [Human squamous cell lung carcinoma] GDSC1 -5.1162 3.9758 -7.3928 50.8441
SW1573 GDSC1 -5.0917 49.1322 -29.531 50.1273
NCI-H748 GDSC1 -5.0282 -2.4965 -5.0941 50.7327
NCI-H3255 GDSC1 -4.962 0.2171 -5.699 49.9677
NCI-H526 GDSC1 -4.7749 -2.5807 -4.818 47.7003
NCI-H510A GDSC1 -4.7625 -3.2956 -4.767 47.4716
NCI-H524 GDSC1 -4.7581 -2.3487 -4.825 47.5363
NCI-H446 GDSC1 -4.7256 -2.2973 -4.7969 47.1555
NCI-H596 GDSC1 -4.7247 3.9354 -6.9765 48.5902
NCI-H2803 GDSC1 -4.7006 -2.1858 -4.785 46.8821
NCI-H1869 GDSC1 -4.6978 -1.3219 -4.9472 47.1142
NCI-H1688 GDSC1 -4.6954 -1.7935 -4.8436 46.9341
NCI-H1651 GDSC1 -4.6855 1.9051 -6.0551 47.959
NCI-H187 GDSC1 -4.6158 -3.4207 -4.6171 45.6312
NCI-H345 GDSC1 -4.3022 4.9419 -7.0135 46.3352
SBC-1 GDSC1 -4.1999 2.6067 -5.8511 44.5739
NCI-H1573 GDSC1 -4.0242 8.5393 -8.4579 46.051
NCI-H1304 GDSC1 -4.018 -0.837 -4.3328 39.6435
RERF-LC-KJ GDSC1 -3.9377 3.7662 -6.1077 43.408
Lu-139 GDSC1 -3.9154 3.1745 -5.8152 42.81
NCI-H69 GDSC1 -3.8925 0.1659 -4.5273 39.4554
SHP-77 GDSC1 -3.841 -0.8145 -4.1462 37.5411
PaCa-3 GDSC1 -3.6493 4.8516 -6.3302 42.2361
NCI-H1963 GDSC1 -3.6366 0.9941 -4.5781 37.9
NCI-H1694 GDSC1 -3.5568 -0.6294 -3.892 34.3289
NCI-H2141 GDSC1 -3.4465 -0.1315 -3.9393 33.8591
Lu-134-A GDSC1 -3.3461 0.2181 -3.9611 33.3351
RERF-LC-Sq1 GDSC1 -2.6428 19.5582 -12.6567 44.3501
NCI-H1650 GDSC1 -2.5387 2.4546 -4.1151 29.5577
COR-L88 GDSC1 -2.2397 5.5374 -5.3317 33.1766
DMS 53 GDSC1 -2.211 3.2578 -4.1877 28.3142
EKVX GDSC1 -1.5636 10.1383 -7.0236 35.1779
NCI-H1155 GDSC1 -1.2583 2.9533 -3.1741 18.0798
NCI-H1876 GDSC1 -1.2411 3.1254 -3.2451 18.4948
Calu-3 GDSC1 -1.111 8.2961 -5.7183 30.083
NCI-H1563 GDSC1 -1.0103 14.2099 -8.5908 36.4462
NCI-H2081 GDSC1 -0.6458 4.9554 -3.6641 18.9539
NCI-H23 GDSC1 -0.6016 12.6098 -7.4525 33.1551
NCI-H1693 GDSC1 -0.5447 5.9099 -4.0593 20.883
NCI-H2795 GDSC1 -0.5279 23.7716 -12.9715 40.2028
NCI-H513 GDSC1 -0.5032 20.127 -11.1292 38.5006
NCI-H2023 GDSC1 -0.3535 10.5333 -6.2134 29.1891
NCI-H1755 GDSC1 -0.3167 22.7426 -12.2835 39.2269
NCI-H1836 GDSC1 -0.1566 8.89 -5.2367 25.1374
NCI-H2029 GDSC1 -0.1218 8.1341 -4.8329 23.3132
Lu-165 GDSC1 -0.0714 7.8112 -4.6331 22.2325
NCI-H1623 GDSC1 -0.0684 11.3228 -6.3791 28.8402
NCI-H2227 GDSC1 0.0676 9.5607 -5.3946 25.0678
NCI-H1793 GDSC1 0.2264 8.7496 -4.8692 22.3945
NCI-H1092 GDSC1 0.2783 11.4238 -6.1568 27.15
NCI-H196 GDSC1 0.2906 9.7941 -5.3379 24.1781
COR-L95 GDSC1 0.4193 6.1436 -3.4427 14.1772
DMS 114 GDSC1 0.4714 9.1533 -4.8832 21.7285
NCI-H841 GDSC1 0.537 16.0495 -8.2557 31.8616
HCC827 GDSC1 0.6064 9.2545 -4.8322 21.1078
NCI-H1993 GDSC1 0.6921 9.0924 -4.6889 20.2012
NCI-H2196 GDSC1 0.7424 10.0625 -5.1291 22.0227
NCI-H720 GDSC1 0.838 2.3972 -1.4851 0.6723
NCI-H322M GDSC1 0.8764 4.8311 -2.5108 6.8125
NCI-H2444 GDSC1 0.9159 2.4025 -1.4554 0.5084
NCI-H1436 GDSC1 1.0029 8.8075 -4.3248 17.5503
NCI-H1666 GDSC1 1.0889 6.7218 -3.2616 11.2491
NCI-H2818 GDSC1 1.1947 9.0035 -4.2849 16.8342
NCI-H2291 GDSC1 1.4869 3.2796 -1.5513 0.4925
DMS 79 GDSC1 1.5149 10.7672 -4.9155 19.0347
NCI-H1838 GDSC1 1.5714 8.9357 -3.9951 14.3456
NCI-H2172 GDSC1 2.5303 15.58 -6.5372 22.7694
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -5.3674 3.2041 -7.3142 52.3681
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-410 GDSC1 -11.7789 -1.8419 -12.5392 80.6579
OE21 GDSC1 -10.8276 1.3912 -12.4531 73.3837
KYSE-70 GDSC1 -10.7725 -1.6991 -11.4771 78.8792
KYSE-150 GDSC1 -9.8892 2.1962 -11.7197 70.261
T.T GDSC1 -9.6346 -6.8599 -9.6373 92.7079
KYSE-270 GDSC1 -9.2285 2.6901 -11.1914 67.9954
TE-8 GDSC1 -9.1972 -0.3948 -10.1111 72.7521
TE-6 GDSC1 -8.7696 5.7652 -11.9394 63.6115
KYSE-510 GDSC1 -8.4903 -7.7323 -8.4903 93.0872
KYSE-180 GDSC1 -8.2805 -4.9417 -8.305 82.2258
KYSE-450 GDSC1 -8.0654 -6.3956 -8.0655 86.2112
TE-10 GDSC1 -8.0231 -1.0964 -8.6324 70.347
KYSE-140 GDSC1 -7.8367 -5.577 -7.8393 82.2019
TE-11 GDSC1 -7.644 2.3103 -9.3522 63.562
TE-15 GDSC1 -7.4364 -5.7191 -7.4367 79.5934
KYSE-520 GDSC1 -7.1618 -5.1133 -7.1642 75.8929
COLO 680N GDSC1 -6.6291 -1.8436 -6.9307 64.7329
OE33 GDSC1 -6.6215 -4.0811 -6.6387 69.0169
TE-1 GDSC1 -6.3259 2.5746 -8.0554 57.7155
TE-9 GDSC1 -6.3135 -0.6839 -6.8813 60.8577
OE19 GDSC1 -4.9421 -0.1281 -5.5599 49.7865
EC-GI-10 GDSC1 -1.4255 4.6394 -4.1601 24.7322
TE-5 GDSC1 -0.4001 13.4481 -7.7069 33.1383
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-OV-3 GDSC1 -12.6092 3.6752 -15.1854 73.2792
OVCAR-5 GDSC1 -10.5476 -1.5153 -11.2779 78.0908
TYK-nu GDSC1 -9.9441 -0.4131 -10.9204 74.6314
TOV-112D GDSC1 -9.3925 -6.6899 -9.3951 91.7957
OVCAR-4 GDSC1 -9.1318 -0.1867 -10.1019 72.1775
IGROV-1 GDSC1 -8.8875 -6.7401 -8.8881 91.0366
Kuramochi GDSC1 -8.76 -2.261 -9.1564 75.6245
A2780 GDSC1 -8.1918 -6.7488 -8.1918 88.1229
OV-90 GDSC1 -8.046 -7.1198 -8.046 87.9395
OVCAR-3 GDSC1 -7.8601 -5.5296 -7.8633 82.1944
OC 314 GDSC1 -7.549 -6.6456 -7.549 82.1288
EFO-21 GDSC1 -6.8262 5.2634 -9.7113 58.0321
OVCAR-8 GDSC1 -6.4008 -1.2756 -6.8155 62.2642
OAW42 GDSC1 -5.6934 -2.4559 -5.8079 57.9274
OVTOKO GDSC1 -5.5901 -3.2412 -5.618 57.4235
RMG-I GDSC1 -5.3732 83.2716 -46.8114 50.2522
EFO-27 GDSC1 -5.2721 2.1788 -6.7837 52.027
Caov-3 GDSC1 -4.0841 4.4552 -6.5715 44.7984
OAW28 GDSC1 -4.0767 0.869 -4.9925 42.1524
ES-2 GDSC1 -3.9983 3.4906 -6.0422 43.6502
FU-OV-1 GDSC1 -3.7263 2.8947 -5.4977 41.0839
OVISE GDSC1 -3.7017 5.0601 -6.4798 42.7265
Caov-4 GDSC1 -3.4098 5.9328 -6.6161 41.5473
TOV-21G GDSC1 0.4907 7.4112 -4.0112 17.3217
OVKATE GDSC1 0.6558 22.4441 -11.3483 36.3657
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 766T GDSC1 -10.8696 2.239 -12.7922 72.243
SW1990 GDSC1 -10.6689 0.6429 -12.0344 74.2607
Capan-2 GDSC1 -9.9741 -3.1978 -10.2898 81.0914
KP-1N GDSC1 -9.3218 -3.3775 -9.5578 80.2183
HPAC GDSC1 -9.2524 -7.4706 -9.2525 94.6082
PSN1 GDSC1 -8.7177 -7.9168 -8.7177 95.0325
Panc 03.27 GDSC1 -8.5428 -7.3219 -8.5428 92.0505
MZ-PC-1 GDSC1 -8.5193 -5.62 -8.5279 85.5955
PaTu 8988t GDSC1 -8.3806 -6.0405 -8.3826 86.6311
KP-2 GDSC1 -8.3775 -5.2676 -8.3925 83.7745
PaTu 8902 GDSC1 -8.1831 7.2383 -11.9699 60.9825
MIA PaCa-2 GDSC1 -7.7746 -4.0427 -7.8352 76.9415
Capan-1 GDSC1 -7.6568 -6.6512 -7.6568 83.3188
Panc 04.03 GDSC1 -7.6544 7.2321 -11.4273 59.5278
Panc 10.05 GDSC1 -7.4948 -6.4012 -7.4948 81.2973
HuP-T4 GDSC1 -7.307 -6.5696 -7.307 79.2357
BxPC-3 GDSC1 -7.1269 -5.0385 -7.1298 75.4288
KP-3 GDSC1 -7.1251 -5.4261 -7.1256 76.1393
KP-4 GDSC1 -7.1058 -4.8457 -7.1111 74.8313
SU.86.86 GDSC1 -6.4953 -5.4028 -6.4954 69.0765
CFPAC-1 GDSC1 -6.2203 -4.3208 -6.2242 65.2638
Panc 08.13 GDSC1 -6.2038 -2.42 -6.3609 62.5349
HuP-T3 GDSC1 -5.9818 -4.8453 -5.9819 62.681
SUIT-2 GDSC1 -5.9365 -3.715 -5.9512 61.6099
PL4 GDSC1 -5.4626 -3.2512 -5.4854 55.9718
HPAF-II GDSC1 -4.2001 -1.3962 -4.388 41.2699
YAPC GDSC1 -3.5325 2.5656 -5.1534 39.0913
Panc 02.03 GDSC1 -2.899 12.5532 -9.397 42.8919
AsPC-1 GDSC1 0.022 11.5557 -6.4236 28.7112
DAN-G GDSC1 0.811 10.2304 -5.1609 21.9656
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 -9.1974 13.1674 -15.6815 60.1216
MPP 89 GDSC1 -6.9191 -5.1254 -6.9203 73.6243
MSTO-211H GDSC1 -4.504 -2.8596 -4.5171 44.2858
IST-Mes1 GDSC1 -2.8705 5.003 -5.6555 37.0068
NCI-H28 GDSC1 0.1381 11.2421 -6.1759 27.6123
NCI-H2452 GDSC1 1.7676 3.6155 -1.5649 0.3999
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 -9.7282 10.8612 -15.1583 62.2648
PC-3 GDSC1 -7.2702 -4.3387 -7.2937 74.8279
DU145 GDSC1 -6.4554 -3.4261 -6.5059 66.3532
VCaP GDSC1 -5.8671 -3.8415 -5.8761 60.9298
LNCaP clone FGC GDSC1 -4.8018 -0.8202 -5.1927 48.3564
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -8.0452 -4.9696 -8.0629 81.3001
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 940.T GDSC1 -9.8466 2.3675 -11.7359 69.9299
IGR-37 GDSC1 -9.7738 2.0435 -11.5405 70.2057
A2058 GDSC1 -9.0483 -5.7221 -9.0627 87.4829
WM793 GDSC1 -8.9154 -6.4166 -8.9175 89.8412
IST-MEL1 GDSC1 -8.8807 -4.0833 -8.994 81.2633
HT-144 GDSC1 -8.3491 -1.4708 -8.8913 72.3683
A-375 GDSC1 -8.1779 -7.2111 -8.1779 89.3027
CP66-MEL GDSC1 -8.0727 -6.4804 -8.0728 86.5193
MZ-MEL-2 GDSC1 -8.0574 -6.9058 -8.0574 87.5795
451Lu GDSC1 -7.9996 -5.1874 -8.0101 81.824
SK-MEL-2 GDSC1 -7.9602 -6.73 -7.9603 86.3562
WM115 GDSC1 -7.8688 10.6584 -13.2009 58.371
RPMI-7951 GDSC1 -7.7218 -2.8603 -7.9214 73.2515
COLO 679 GDSC1 -7.6953 -6.7773 -7.6953 83.8752
IPC-298 GDSC1 -7.6835 0.7401 -8.8248 65.764
Mel JuSo GDSC1 -7.6708 -5.957 -7.6711 82.118
WM278 GDSC1 -7.5923 -6.1777 -7.5924 81.9311
SH-4 GDSC1 -7.5759 -6.6691 -7.5759 82.4517
G-361 GDSC1 -7.5512 -6.4795 -7.5512 81.9911
A101D GDSC1 -7.4927 -5.4828 -7.4942 79.5126
LOX-IMVI GDSC1 -7.492 -4.6839 -7.5074 77.2919
A-431 GDSC1 -7.4758 -5.3911 -7.4778 79.1471
WM35 GDSC1 -7.4237 -5.9418 -7.4238 79.9086
A-388 GDSC1 -7.3821 -5.8303 -7.3822 79.3138
Mel Ho GDSC1 -7.1876 -1.4594 -7.6277 67.3053
WM1552C GDSC1 -7.1801 -5.2041 -7.1818 76.2434
SK-MEL-3 GDSC1 -7.0726 -4.4713 -7.0861 73.6961
M14 GDSC1 -7.0713 -5.8246 -7.0713 76.072
COLO 800 GDSC1 -7.0362 -4.6858 -7.0435 73.8874
RVH-421 GDSC1 -7.0231 -5.9879 -7.0231 75.6224
CHL-1 GDSC1 -6.9963 -5.8236 -6.9963 75.2172
SK-MEL-30 GDSC1 -6.8891 1.9311 -8.4008 60.9122
HMV-II GDSC1 -6.6631 -3.239 -6.7416 67.7096
LB2518-MEL GDSC1 -6.6446 -6.0121 -6.6446 70.9844
COLO 829 GDSC1 -6.4305 -2.3186 -6.6222 64.1681
VMRC-MELG GDSC1 -6.3452 -2.8546 -6.4492 64.4136
IGR-1 GDSC1 -6.2705 -3.3033 -6.3226 64.4867
CP50-MEL-B GDSC1 -6.2255 -4.1678 -6.2323 65.1778
MMAc-SF GDSC1 -5.2313 -1.4464 -5.499 52.7245
LB373-MEL-D GDSC1 -5.1281 -0.8829 -5.5312 51.5742
Hs 938.T GDSC1 -5.0883 -2.9211 -5.118 51.4793
G-mel GDSC1 -5.0748 -3.7466 -5.0762 51.3594
SK-MEL-5 GDSC1 -4.9055 163.6089 -86.5589 49.9804
MZ-MEL-7 GDSC1 -4.8062 0.5016 -5.6327 48.6451
DJM-1 GDSC1 -4.4176 0.6894 -5.286 45.2391
UACC-62 GDSC1 -4.1584 1.499 -5.3343 43.4626
COLO 783 GDSC1 -4.0626 0.8737 -4.9795 42.0208
COLO 792 GDSC1 -3.9002 -0.8214 -4.2087 38.2489
UACC-257 GDSC1 -3.2865 1.339 -4.3586 34.8388
GAK GDSC1 -2.2082 3.4084 -4.2585 28.6529
SK-MEL-1 GDSC1 -0.9496 4.2935 -3.5819 19.5548
WT2-iPS GDSC1 -0.233 21.9994 -11.8436 38.6549
SK-MEL-28 GDSC1 0.1182 3.8904 -2.5607 9.0448
MeWo GDSC1 0.2374 9.6593 -5.3119 24.232
SK-MEL-24 GDSC1 0.2727 2.8918 -1.9862 4.5071
EquiPSC Line K2 GDSC1 -6.3493 -4.1187 -6.3593 66.4275
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -7.9316 -6.6457 -7.9317 85.9195
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 -9.8642 6.6443 -13.4511 65.4181
MES-SA GDSC1 -8.5194 -6.8586 -8.5195 90.2557
HT-1080 GDSC1 -8.3836 -7.8809 -8.3836 92.5063
SK-LMS-1 GDSC1 -8.3552 -2.0813 -8.7551 73.8274
SW982 GDSC1 -8.1737 -5.5947 -8.1787 84.0915
Hs 633.T GDSC1 -8.0506 -7.184 -8.0506 88.0982
KYM-1 GDSC1 -7.9835 -7.0045 -7.9835 87.1385
MFH-ino GDSC1 -7.8364 -5.9702 -7.837 83.3942
G-402 GDSC1 -7.6718 -5.7549 -7.6726 81.6001
GCT GDSC1 -7.2998 -4.9272 -7.3059 76.5981
STS-0421 GDSC1 -7.2691 -5.8558 -7.2692 78.2365
SW872 GDSC1 -7.2656 -3.9359 -7.3123 73.7019
RD GDSC1 -7.1359 -5.2164 -7.1374 75.8678
Rh30 GDSC1 -7.0645 -5.4936 -7.0648 75.631
A-204 GDSC1 -6.9619 -1.0823 -7.4781 65.3803
VA-ES-BJ GDSC1 -6.9232 -1.5156 -7.3258 65.9528
EW-8 GDSC1 -6.6642 -4.595 -6.6686 70.2776
SK-UT-1 GDSC1 -6.6333 -2.8433 -6.7577 66.6755
Rh41 GDSC1 -5.5036 -3.1263 -5.5358 56.3852
TE 441.T GDSC1 -3.9159 -0.3015 -4.3884 39.1078
SW684 GDSC1 0.7531 10.5684 -5.3705 22.9838
RKN GDSC1 5.2099 24.9174 -9.1925 24.6427
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1 -9.7887 -8.0327 -9.7887 96.9496
NUGC-4 GDSC1 -9.4481 -6.9468 -9.4495 92.8425
Fu97 GDSC1 -8.2379 -7.3805 -8.2379 90.199
NUGC-3 GDSC1 -8.0637 -5.4022 -8.0706 82.8836
IM95 GDSC1 -7.821 -6.4479 -7.8211 84.5305
TMK-1 GDSC1 -7.8137 -6.4889 -7.8137 84.5587
MKN28 GDSC1 -7.5823 -5.8857 -7.5826 81.2206
ECC10 GDSC1 -7.3789 -5.6909 -7.3793 79.0203
OCUM-1 GDSC1 -6.992 -5.583 -6.9921 74.967
AGS GDSC1 -6.5632 -4.1033 -6.5782 68.5144
MKN45 GDSC1 -6.2806 -2.5623 -6.4211 63.3938
SNU-1 GDSC1 -5.8625 -0.7384 -6.3735 57.7411
RERF-GC-1B GDSC1 -5.5381 -0.912 -5.9704 55.277
23132/87 GDSC1 -5.0836 -1.3118 -5.3701 51.2114
MKN1 GDSC1 -4.2635 6.3951 -7.6584 46.578
GCIY GDSC1 -4.2003 0.5116 -4.986 43.0316
HSC-39 GDSC1 -3.7937 -0.6727 -4.1367 37.162
SNU-16 GDSC1 -3.6325 0.8857 -4.5294 37.6928
SNU-5 GDSC1 -3.6245 0.1385 -4.2292 36.4195
RF-48 GDSC1 -2.8086 3.5165 -4.8812 34.2651
TGBC11TKB GDSC1 -0.7102 5.8318 -4.154 21.9779
MKN7 GDSC1 -0.5909 7.4961 -4.8885 25.1063
NCI-N87 GDSC1 0.7157 16.3892 -8.2848 31.4925
SCH GDSC1 0.8496 2.1104 -1.3755 0.2969
SNG-M GDSC1 -8.3711 -7.2326 -8.3711 90.7813
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C GDSC1 -10.4429 -6.2563 -10.4691 91.1409
ML-1 [Human leukemia] GDSC1 -10.3812 2.3143 -12.2924 71.1718
ASH-3 GDSC1 -9.4683 -7.0184 -9.4694 93.1358
8305C GDSC1 -9.4409 6.3763 -12.8968 64.7162
TT2609-C02 GDSC1 -9.2375 -7.3873 -9.2376 94.2663
IHH-4 GDSC1 -8.8232 -7.8547 -8.8232 95.2182
CGTH-W-1 GDSC1 -8.598 -7.6999 -8.598 93.6594
KMH-2 GDSC1 -8.5836 -7.8203 -8.5836 93.975
B-CPAP GDSC1 -8.3922 -7.5087 -8.3922 91.7486
BHT-101 GDSC1 -6.4709 0.8772 -7.5616 59.9579
CAL-62 GDSC1 -6.0891 -1.4192 -6.44 60.2202
HTC-C3 GDSC1 -5.5298 0.4478 -6.3934 54.4053
TT GDSC1 -1.9037 2.9138 -3.7336 24.4084
K5 GDSC1 -0.8405 3.8951 -3.2926 17.2879
WRO GDSC1 0.2197 18.9859 -9.9717 35.5126
FTC-133 GDSC1 0.951 4.9601 -2.5246 6.7417
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OSC-19 GDSC1 -8.5369 -5.7179 -8.544 86.0244
LB771-HNC GDSC1 -8.4912 2.4938 -10.3279 66.1738
PCI-04B GDSC1 -8.3038 -3.4009 -8.4644 77.2449
NCI-H3118 GDSC1 -8.2749 -6.7499 -8.2749 88.6355
BHY GDSC1 -8.2283 -7.5402 -8.2283 90.4262
PCI-06A GDSC1 -8.0149 -6.8973 -8.0149 87.2025
CAL-27 GDSC1 -7.9812 -6.8935 -7.9812 86.899
HSC-2 GDSC1 -7.9696 -6.4069 -7.9697 85.5897
KON GDSC1 -7.921 -6.9342 -7.921 86.4168
BB30-HNC GDSC1 -7.4819 -6.1784 -7.4819 80.8675
JHU-011 GDSC1 -7.351 -5.9469 -7.3511 79.2015
Ca9-22 GDSC1 -7.1366 -5.2374 -7.138 75.9145
Detroit 562 GDSC1 -7.1163 -5.4953 -7.1167 76.1614
SCC-15 GDSC1 -6.882 -4.4338 -6.8929 72.0249
HO-1-u-1 GDSC1 -6.8251 -5.3762 -6.8253 72.928
OSC-20 GDSC1 -6.7955 -2.6592 -6.9584 67.4549
SCC-25 GDSC1 -6.6121 -2.4924 -6.7881 65.828
JHU-029 GDSC1 -6.5586 -3.8137 -6.5867 67.964
SCC-4 GDSC1 -6.4878 -3.2986 -6.551 66.4007
HSC-3 GDSC1 -6.3569 -3.9899 -6.3712 66.3335
PCI-15A GDSC1 -6.1274 -3.8681 -6.1409 63.8164
UPCI-SCC-090 GDSC1 -5.9821 0.8979 -7.0423 57.1226
KOSC-2 GDSC1 -5.9624 7.5891 -9.8871 53.8962
FaDu GDSC1 -5.8546 -3.6434 -5.8701 60.6483
BICR 22 GDSC1 -5.2614 23.5809 -16.9801 50.5586
SCC-9 GDSC1 -4.8343 7.0201 -8.5099 49.4171
CAL-33 GDSC1 -4.8147 0.1701 -5.5234 48.6651
BICR 31 GDSC1 -4.7287 2.8791 -6.5139 48.4567
BICR 78 GDSC1 -4.7046 1.5427 -5.9267 48.0208
SAT [Human HNSCC] GDSC1 -3.8593 11.6032 -9.799 46.1789
SAS GDSC1 -2.975 31.2245 -18.7645 46.8242
SKN-3 GDSC1 -1.461 1.8088 -2.7846 16.125
HO-1-N-1 GDSC1 -0.5211 8.4498 -5.3083 26.5969
PCI-38 GDSC1 -0.2949 11.3696 -6.5837 30.0987
HSC-4 GDSC1 0.263 15.9935 -8.4444 32.9012
DOK GDSC1 0.4384 10.0207 -5.3372 23.7428
BICR 10 GDSC1 0.8654 18.4277 -9.1819 32.8431
BB49-HNC GDSC1 1.0418 17.2842 -8.4764 31.1232
PE/CA-PJ15 GDSC1 1.3134 3.5009 -1.7051 1.2008
JHU-022 GDSC1 1.3837 12.6203 -5.9142 23.3625
PCI-30 GDSC1 1.4986 11.0489 -5.0638 19.7277
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 -10.5148 -5.049 -10.6196 87.3068
639V GDSC1 -9.0461 -6.975 -9.0465 92.3266
BFTC-905 GDSC1 -8.6325 -7.2945 -8.6325 92.3592
UM-UC-3 GDSC1 -7.5835 -6.0044 -7.5836 81.4969
RT-4 GDSC1 -7.4194 -6.0193 -7.4195 79.9965
J82 GDSC1 -7.1059 0.2389 -8.0305 63.9935
T24 GDSC1 -7.009 -5.5898 -7.0091 75.1594
RT-112 GDSC1 -6.9963 -4.8889 -6.9999 73.9567
5637 GDSC1 -6.941 -5.4878 -6.9412 74.313
647V GDSC1 -6.7381 -4.9038 -6.7397 71.4641
HT-1376 GDSC1 -6.2372 1.0237 -7.3626 58.5197
TCCSUP GDSC1 -4.135 11.4947 -10.0007 47.1576
KU-19-19 GDSC1 -3.8877 2.633 -5.5437 42.1387
CAL-29 GDSC1 -1.8936 1.9504 -3.2544 21.3364
SW780 GDSC1 -0.9213 4.7491 -3.7862 20.6854
HT-1197 GDSC1 -0.4866 11.2008 -6.6545 30.8659
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -9.4451 -7.4334 -9.4453 94.6763
NCC-IT GDSC1 -8.9451 -3.6993 -9.1082 80.2216
CAL-39 GDSC1 -8.7343 -0.0177 -9.7205 70.7056
KGN GDSC1 -8.6805 -6.4192 -8.6817 89.184
PA-1 GDSC1 -8.4773 -7.4379 -8.4773 92.0926
LB831-BLC GDSC1 -7.9193 0.1344 -8.881 67.6399
HeLa GDSC1 -7.7896 -6.5728 -7.7896 84.5161
SiSo GDSC1 -7.5418 -5.9483 -7.542 81.0105
C-33 A GDSC1 -6.9719 -2.9532 -7.1041 69.292
C-4-I GDSC1 -6.8867 -4.2211 -6.905 71.6137
NEC8 GDSC1 -6.573 -4.4992 -6.5779 69.2212
JEG-3 GDSC1 -6.5722 -3.1524 -6.6549 66.8176
DSH1 GDSC1 -6.4862 -4.9423 -6.4868 68.7547
OVMIU GDSC1 -6.3596 0.094 -7.1723 60.1918
DoTc2 4510 GDSC1 -6.3334 -2.0961 -6.5583 63.0589
BPH-1 GDSC1 -6.3208 0.0148 -7.1044 60.0494
SW962 GDSC1 -6.2574 -1.1276 -6.6973 61.0668
SW756 GDSC1 -6.0744 -2.615 -6.1926 61.6997
MS751 GDSC1 -5.9494 -2.5574 -6.0672 60.4877
SKN GDSC1 -5.8642 8.5621 -10.2438 53.3141
HT-3 GDSC1 -5.5434 0.5554 -6.4463 54.4468
SW954 GDSC1 -5.4164 0.2622 -6.2061 53.6515
Ca Ski GDSC1 -5.3633 -2.5546 -5.4427 54.5459
HEC-1 GDSC1 -4.8822 5.1684 -7.695 49.57
OMC-1 [Human cervical carcinoma] GDSC1 -3.6401 1.3759 -4.7412 38.4905
SKG-IIIa GDSC1 -0.2005 6.4872 -4.0753 19.8105
ME-180 GDSC1 0.9624 9.6606 -4.7703 19.8274
JAR GDSC1 1.2635 2.8487 -1.4821 0.4013
SiHa GDSC1 1.2673 2.3547 -1.3115 0.0675
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46.
2 Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
3 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
4 Proteomic signatures in thapsigargin-treated hepatoma cells. Chem Res Toxicol. 2011 Aug 15;24(8):1215-22. doi: 10.1021/tx200109y. Epub 2011 Jul 1.