Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT6P2PMP)

DOT Name	Protein CEBPZOS (CEBPZOS)
Synonyms	CEBPZ antisense RNA 1; CEBPZ opposite strand
Gene Name	CEBPZOS
UniProt ID	CEBOS_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MARTLEPLAKKIFKGVLVAELVGVFGAYFLFSKMHTSQDFRQTMSKKYPFILEVYYKSTE KSGMYGIRELDQKTWLNSKN

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

4 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the expression of Protein CEBPZOS (CEBPZOS).	[1]
Doxorubicin	DMVP5YE	Approved	Doxorubicin decreases the expression of Protein CEBPZOS (CEBPZOS).	[2]
Cisplatin	DMRHGI9	Approved	Cisplatin increases the expression of Protein CEBPZOS (CEBPZOS).	[3]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Protein CEBPZOS (CEBPZOS).	[4]
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References

1	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2	Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
3	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
4	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.