Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8BO5UR)

DOT Name	Olfactory receptor 3A2 (OR3A2)
Synonyms	Olfactory receptor 17-228; OR17-228; Olfactory receptor OR17-14
Gene Name	OR3A2
Related Disease	Cocaine addiction ( )
UniProt ID	OR3A2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF13853
Sequence	MSLQKLMEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGGNLSILAAVLV EPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMD CFLLTAMAYDRLLAICQPLTYSTRMSQTVQRMLVAASLACAFTNALTHTVAMSTLNFCGP NEVNHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPLVLIITAYSHVAAAVLRIRSV EGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEEASDKDKGVGVFNTVINPMLNPLIYS LRNPDVQGALWQIFLGRRSLT
Function	Odorant receptor.
KEGG Pathway	Olfactory transduction (hsa04740 )
Reactome Pathway	Expression and translocation of olfactory receptors (R-HSA-9752946 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Cocaine addiction	DISHTRXG	Limited	Genetic Variation	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Olfactory receptor 3A2 (OR3A2).	[2]
------------------------------------------------------------------------------------

References

1	Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Mol Psychiatry. 2014 Jun;19(6):717-23. doi: 10.1038/mp.2013.99. Epub 2013 Aug 20.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.