Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT9GJBI3)

DOT Name Spermatogenesis-associated protein 16 (SPATA16)
Synonyms Testis development protein NYD-SP12
Gene Name SPATA16
Related Disease
Hepatitis C virus infection ( )
Male infertility ( )
Spermatogenic failure 9 ( )
Male infertility due to globozoospermia ( )
Spermatogenic failure 6 ( )
UniProt ID
SPT16_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15015
Sequence
MDAGSSRSLENAVNRIYHDQLVPKINTSKKMSTLAHPPNILEMSQEIKKNCGGKQVEITL
ERTKMTKGIKEKQSNDLEKAAFKRKAEGEEKPTRKKQAKITELDNQLITMPLPHIPLKNI
MDVEMKLVYIDEMGVRYEFVESFMSTGSQPTCQAAEIVDPLSVHNFSFLPQIDKWLQVAL
KDASSCYRQKKYALAAGQFRTALELCSKGAVLGEPFDAPAEDIASVASFIETKLVTCYLR
MRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLGGGREE
SISKLIKLYWQAMIEEAITRAESFSVMYTPFATKIRADKIEKVKDAFTKTHPAYAEYMYT
DLQALHMLPQTVDWSSFPPQQYLLTLGFKNKDDGKFLEKISSRKLPIFTEHKTPFGLTRE
DTVRQMETMGKRILPILDFIRSTQLNGSFPASSGVMEKLQYASLLSQLQRVKEQSQVINQ
AMAELATIPYLQDISQQEAELLQSLMADAMDTLEGRRNNNERVWNMIQKVGQIEDFLYQL
EDSFLKTKKLRTARRQKTKMKRLQTVQQR
Function Essential for spermiogenesis and male fertility. Involved in the formation of sperm acrosome during spermatogenesis.
Tissue Specificity Expressed in testis.

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hepatitis C virus infection DISQ0M8R Strong Genetic Variation [1]
Male infertility DISY3YZZ Strong Genetic Variation [2]
Spermatogenic failure 9 DISJEBH2 Strong Genetic Variation [3]
Male infertility due to globozoospermia DIS7EMCO Supportive Autosomal recessive [2]
Spermatogenic failure 6 DISCK87Z Limited Autosomal recessive [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Spermatogenesis-associated protein 16 (SPATA16). [4]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the methylation of Spermatogenesis-associated protein 16 (SPATA16). [5]
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References

1 Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.J Interferon Cytokine Res. 2019 Oct;39(10):642-649. doi: 10.1089/jir.2019.0013. Epub 2019 Jul 1.
2 Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia. Am J Hum Genet. 2007 Oct;81(4):813-20. doi: 10.1086/521314. Epub 2007 Aug 21.
3 Comparison of sperm morphology and nuclear sperm quality in SPATA16- and DPY19L2-mutated globozoospermic patients.Andrologia. 2019 Jul;51(6):e13277. doi: 10.1111/and.13277. Epub 2019 Mar 26.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
5 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.