Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTAMOJGN)

• DOT Name: Trichohyalin-like protein 1 (TCHHL1)
• Synonyms: Basalin; Protein S100-A17; S100 calcium-binding protein A17
• Gene Name: TCHHL1
• Related Disease:
  Non-insulin dependent diabetes
  Anaplastic large cell lymphoma
  Classic Hodgkin lymphoma
  Peripheral neuropathy
  Lichen planus
  Neoplasm
  Squamous cell carcinoma
• UniProt ID: TCHL1_HUMAN
• Pfam ID: PF01023
• Sequence:
  MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLL
  NIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQ
  WTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKN
  KHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAR
  EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPS
  SQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS
  ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ
  TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF
  VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT
  QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP
  GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA
  GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL
  LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK
  QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLT
  SEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREAS
  TTKQ

Molecular Interaction Atlas (MIA) of This DOT

7 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Non-insulin dependent diabetes	DISK1O5Z	Definitive	Biomarker	[1]
Anaplastic large cell lymphoma	DISP4D1R	Strong	Altered Expression	[2]
Classic Hodgkin lymphoma	DISV1LU6	Strong	Altered Expression	[3]
Peripheral neuropathy	DIS7KN5G	Strong	Biomarker	[4]
Lichen planus	DISRPMMS	moderate	Altered Expression	[5]
Neoplasm	DISZKGEW	moderate	Altered Expression	[5]
Squamous cell carcinoma	DISQVIFL	moderate	Altered Expression	[5]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Malathion	DMXZ84M	Approved	Malathion decreases the expression of Trichohyalin-like protein 1 (TCHHL1).	[6]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Trichohyalin-like protein 1 (TCHHL1).	[7]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Trichohyalin-like protein 1 (TCHHL1).	[8]

References

• [1] A comparison of clinical efficacy and economic value in Basalin- and Lantus-treated patients with type 2 diabetes using continuous glucose monitoring system.J Endocrinol Invest. 2018 Feb;41(2):179-184. doi: 10.1007/s40618-017-0712-0. Epub 2017 Jun 22.
• [2] Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma.Blood. 1992 Dec 1;80(11):2891-6.
• [3] Restin in Hodgkin's disease and anaplastic large cell lymphoma.Leuk Lymphoma. 1993 Dec;12(1-2):21-6. doi: 10.3109/10428199309059567.
• [4] Investigation on effect of basalin coated silver nanoparticles as antioxidant for alleviating peripheral neuropathy in mice treated with oxaliplatin.J Photochem Photobiol B. 2017 Dec;177:56-61. doi: 10.1016/j.jphotobiol.2017.10.003. Epub 2017 Oct 2.
• [5] Trichohyalin-like 1 protein, a member of fused S100 proteins, is expressed in normal and pathologic human skin.Biochem Biophys Res Commun. 2013 Mar 1;432(1):66-72. doi: 10.1016/j.bbrc.2013.01.084. Epub 2013 Jan 29.
• [6] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [7] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [8] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.