Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTCCJKFN)

• DOT Name: MORC family CW-type zinc finger protein 1 (MORC1)
• Synonyms: Cancer/testis antigen 33; CT33
• Gene Name: MORC1
• Related Disease:
  Advanced cancer
  B-cell lymphoma
  Depression
  Major depressive disorder
• UniProt ID: MORC1_HUMAN
• Pfam ID: PF13589 ; PF17942 ; PF07496
• Sequence:
  MDDRYPALQRAQLRLDFIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGG
  FMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKK
  EETMTCVFFSQTFCEEESLSEVVVPMPSWLIRTRESVTDDPQKFAMELSIIYKYSPFKTE
  AELMQQFDVIYGKCGTLLVIYNLKLLLNGEPELDVKTDKEDILMAGALEDFPARWSFRAY
  TSVLYFNPWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAFKDEVKKAEEAVKIAE
  SILKEAQIKVNQCDRTSLSSAKDVLQRALEDVEAKQKNLKEKQRELKTARTLSLFYGVNV
  ENRSQAGMFIYSNNRLIKMHEKVGSQLKLKSLLGAGVVGIVNIPLEVMEPSHNKQEFLNV
  QEYNHLLKVMGQYLVQYCKDTGINNRNLTLFCNEFGYQNDIDVEKPLNSFQYQRRQAMGI
  PFIIQCDLCLKWRVLPSSTNYQEKEFFDIWICANNPNRLENSCHQVECLPSIPLGTMSTI
  SPSKNEKEKQLRESVIKYQNRLAEQQPQPQFIPVDEITVTSTCLTSAHKENTKTQKIRLL
  GDDLKHESLSSFELSASRRGQKRNIEETDSDVEYISETKIMKKSMEEKMNSQQQRIPVAL
  PENVKLAERSQRSQIANITTVWRAQPTEGCLKNAQAASWEMKRKQSLNFVEECKVLTEDE
  NTSDSDIILVSDKSNTDVSLKQEKKEIPLLNQEKQELCNDVLAMKRSSSLPSWKSLLNVP
  MEDVNLSSGHIARVSVSGSCKVASSPASSQSTPVKETVRKLKSKLREILLYFFPEHQLPS
  ELEEPALSCELEQCPEQMNKKLKMCFNQIQNTYMVQYEKKIKRKLQSIIYDSNTRGIHNE
  ISLGQCENKRKISEDKLKNLRIKLALLLQKLQLGGPEGDLEQTDTYLEALLKEDNLLFQN
  NLNKVTIDARHRLPLEKNEKTSEN
• Function: Required for spermatogenesis. Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells.

Molecular Interaction Atlas (MIA) of This DOT

4 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Biomarker	[1]
B-cell lymphoma	DISIH1YQ	Strong	Altered Expression	[2]
Depression	DIS3XJ69	Strong	Biomarker	[3]
Major depressive disorder	DIS4CL3X	Strong	Biomarker	[4]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the methylation of MORC family CW-type zinc finger protein 1 (MORC1).	[5]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of MORC family CW-type zinc finger protein 1 (MORC1).	[6]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of MORC family CW-type zinc finger protein 1 (MORC1).	[7]

References

• [1] The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis.J Cell Physiol. 2017 May;232(5):928-934. doi: 10.1002/jcp.25665. Epub 2016 Nov 30.
• [2] MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas.Br J Haematol. 2007 Aug;138(4):479-86. doi: 10.1111/j.1365-2141.2007.06680.x. Epub 2007 Jun 29.
• [3] Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.J Psychiatr Res. 2020 Jan;120:154-162. doi: 10.1016/j.jpsychires.2019.10.019. Epub 2019 Oct 26.
• [4] Methylation of MORC1: A possible biomarker for depression?.J Psychiatr Res. 2018 Aug;103:208-211. doi: 10.1016/j.jpsychires.2018.05.026. Epub 2018 May 30.
• [5] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [6] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [7] BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.