General Information of Drug Off-Target (DOT) (ID: OTEVRCBO)

DOT Name Large ribosomal subunit protein eL28 (RPL28)
Synonyms 60S ribosomal protein L28
Gene Name RPL28
Related Disease
Colon cancer ( )
Colon carcinoma ( )
Neoplasm ( )
UniProt ID
RL28_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4UG0 ; 4V6X ; 5AJ0 ; 5LKS ; 5T2C ; 6IP5 ; 6IP6 ; 6IP8 ; 6LQM ; 6LSR ; 6LSS ; 6LU8 ; 6OLE ; 6OLF ; 6OLG ; 6OLI ; 6OLZ ; 6OM0 ; 6OM7 ; 6QZP ; 6W6L ; 6XA1 ; 6Y0G ; 6Y2L ; 6Y57 ; 6Y6X ; 6Z6L ; 6Z6M ; 6Z6N ; 6ZM7 ; 6ZME ; 6ZMI ; 6ZMO ; 7BHP ; 7F5S ; 7OW7 ; 7QVP ; 7XNX ; 7XNY ; 8A3D ; 8FKQ ; 8FKS ; 8FKU ; 8FKW ; 8FKX ; 8FKY ; 8FKZ ; 8FL0 ; 8FL2 ; 8FL3 ; 8FL4 ; 8FL6 ; 8FL7 ; 8FL9 ; 8FLA ; 8FLB ; 8FLC ; 8FLD ; 8FLE ; 8FLF ; 8G5Y ; 8G5Z ; 8G60 ; 8G61 ; 8G6J ; 8GLP ; 8IDT ; 8IDY ; 8IE3 ; 8INE ; 8INF ; 8INK ; 8IPD ; 8IPX ; 8IPY ; 8IR1 ; 8IR3 ; 8JDJ ; 8JDK ; 8JDL ; 8JDM
Pfam ID
PF01778
Sequence
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGV
VVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRS
QKPVMVKRKRTRPTKSS
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
KEGG Pathway
Ribosome (hsa03010 )
Coro.virus disease - COVID-19 (hsa05171 )
Reactome Pathway
Peptide chain elongation (R-HSA-156902 )
SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 )
Viral mRNA Translation (R-HSA-192823 )
Selenocysteine synthesis (R-HSA-2408557 )
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )
Formation of a pool of free 40S subunits (R-HSA-72689 )
GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
Eukaryotic Translation Termination (R-HSA-72764 )
Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )
Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 )
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 )
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 )
L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Colon cancer DISVC52G moderate Biomarker [1]
Colon carcinoma DISJYKUO moderate Biomarker [1]
Neoplasm DISZKGEW moderate Altered Expression [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Large ribosomal subunit protein eL28 (RPL28). [2]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Large ribosomal subunit protein eL28 (RPL28). [11]
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11 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Large ribosomal subunit protein eL28 (RPL28). [3]
Doxorubicin DMVP5YE Approved Doxorubicin affects the expression of Large ribosomal subunit protein eL28 (RPL28). [4]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Large ribosomal subunit protein eL28 (RPL28). [5]
Quercetin DM3NC4M Approved Quercetin increases the expression of Large ribosomal subunit protein eL28 (RPL28). [6]
Carbamazepine DMZOLBI Approved Carbamazepine affects the expression of Large ribosomal subunit protein eL28 (RPL28). [7]
Phenytoin DMNOKBV Approved Phenytoin increases the expression of Large ribosomal subunit protein eL28 (RPL28). [8]
Genistein DM0JETC Phase 2/3 Genistein increases the expression of Large ribosomal subunit protein eL28 (RPL28). [9]
Tocopherol DMBIJZ6 Phase 2 Tocopherol decreases the expression of Large ribosomal subunit protein eL28 (RPL28). [10]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Large ribosomal subunit protein eL28 (RPL28). [12]
Milchsaure DM462BT Investigative Milchsaure increases the expression of Large ribosomal subunit protein eL28 (RPL28). [13]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Large ribosomal subunit protein eL28 (RPL28). [14]
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⏷ Show the Full List of 11 Drug(s)

References

1 Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients.Sci Rep. 2019 Sep 10;9(1):13008. doi: 10.1038/s41598-019-49477-3.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
4 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
5 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
6 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
7 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
8 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
9 The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
10 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
11 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
12 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
13 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
14 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.