Details of the Drug

General Information of Drug (ID: DMBIJZ6)

Drug Name
Tocopherol
Synonyms Methyltocols; tocoferol; tocoferoles; tocophrol; Tocopherols
Affected Organisms
Humans and other mammals
Structure
3D MOL 2D MOL
ADMET Property
Bioavailability
The bioavailability of drug is 89% [1]
Clearance
The clearance of drug is 6.5 mL/h/kg [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 44 hours [2]
Metabolism
The drug is metabolized via the cytochrome P450s such as CYP4F2, CYP3A4, and CYP3A5 [3]
Vd
The volume of distribution (Vd) of drug is 0.41 L/kg [2]
Cross-matching ID
PubChem CID
14985
UNII
R0ZB2556P8
DrugBank ID
DB11251
INTEDE ID
DR1608

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 4F2 (CYP4F2) DE3GT9C CP4F2_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) OTX1DWEF DHB8_HUMAN Gene/Protein Processing [6]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Gene/Protein Processing [6]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4) OTPA0QHW PLCB4_HUMAN Gene/Protein Processing [6]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [6]
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [6]
18S rRNA aminocarboxypropyltransferase (TSR3) OTR3RQ6I TSR3_HUMAN Gene/Protein Processing [6]
2-hydroxyacylsphingosine 1-beta-galactosyltransferase OT17ST61 CGT_HUMAN Gene/Protein Processing [6]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) OT6HZHN7 PSMD2_HUMAN Gene/Protein Processing [6]
26S proteasome non-ATPase regulatory subunit 4 (PSMD4) OTH1VZTM PSMD4_HUMAN Gene/Protein Processing [6]
26S proteasome regulatory subunit 4 (PSMC1) OTLHD56E PRS4_HUMAN Gene/Protein Processing [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Balfour JA, Bryson HM, Brogden RN: Imipenem/cilastatin: an update of its antibacterial activity, pharmacokinetics and therapeutic efficacy in the treatment of serious infections. Drugs. 1996 Jan;51(1):99-136. doi: 10.2165/00003495-199651010-00008.
2 Pharmacokinetics of a single intramuscular injection of vitamin E to premature neonates. Pediatr Pharmacol (New York). 1983;3(1):7-14.
3 Reidenberg MM, Drayer D, DeMarco AL, Bello CT: Hydralazine elimination in man. Clin Pharmacol Ther. 1973 Nov-Dec;14(6):970-7. doi: 10.1002/cpt1973146970.
4 A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels. Atherosclerosis. 2007 Jul;193(1):229-33.
5 Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci. 2004 Dec;1031:13-21.
6 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.