Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMX0C5Z)

DOT Name ARL14 effector protein-like (ARL14EPL)
Gene Name ARL14EPL
UniProt ID
A14EL_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF14949
Sequence
MNEQSEKNNSIQERHTDHSFPEKNCQIGQKQLQQIERQLKCLAFRNPGPQVADFNPETRQ
QKKKARMSKMNEYFSTKYKIMRKYDKSGRLICNDADLCDCLEKNCLGCFYPCPKCNSNKC
GPECRCNRRWVYDAIVTESGEVISTLPFNVPD

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin increases the expression of ARL14 effector protein-like (ARL14EPL). [1]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 decreases the expression of ARL14 effector protein-like (ARL14EPL). [2]
------------------------------------------------------------------------------------

References

1 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
2 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.