Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTNCB038)

• DOT Name: snRNA-activating protein complex subunit 5 (SNAPC5)
• Synonyms: SNAPc subunit 5; Small nuclear RNA-activating complex polypeptide 5; snRNA-activating protein complex 19 kDa subunit; SNAPc 19 kDa subunit
• Gene Name: SNAPC5
• Related Disease: Melanoma
• UniProt ID: SNPC5_HUMAN
• PDB ID: 7ZWC; 7ZWD; 7ZX7; 7ZX8; 7ZXE
• Pfam ID: PF15497
• Sequence:
  MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHD
  MLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS
• Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
• Reactome Pathway:
  RNA Polymerase III Abortive And Retractive Initiation (R-HSA-749476)
  RNA Polymerase III Transcription Initiation From Type 3 Promoter (R-HSA-76071)
  RNA polymerase II transcribes snRNA genes (R-HSA-6807505)

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Melanoma	DIS1RRCY	Definitive	CausalMutation	[1]

6 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[2]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[3]
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide decreases the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[4]
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[5]
Trichostatin A	DM9C8NX	Investigative	Trichostatin A affects the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[6]
Taurine	DMVW7N3	Investigative	Taurine increases the expression of snRNA-activating protein complex subunit 5 (SNAPC5).	[7]

References

• [1] Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.Nat Genet. 2011 Dec 25;44(2):133-9. doi: 10.1038/ng.1026.
• [2] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [3] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [4] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [5] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [6] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [7] Taurine-responsive genes related to signal transduction as identified by cDNA microarray analyses of HepG2 cells. J Med Food. 2006 Spring;9(1):33-41. doi: 10.1089/jmf.2006.9.33.