Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQEXCKU)

DOT Name Cadherin-7 (CDH7)
Gene Name CDH7
Related Disease
Bipolar disorder ( )
Familial adenomatous polyposis ( )
Major depressive disorder ( )
Mental disorder ( )
Neoplasm ( )
Age-related macular degeneration ( )
Autism ( )
Melanoma ( )
Colorectal carcinoma ( )
Colorectal neoplasm ( )
UniProt ID
CADH7_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF01049 ; PF00028
Sequence
MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
ESLYS
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Reactome Pathway
Adherens junctions interactions (R-HSA-418990 )

Molecular Interaction Atlas (MIA) of This DOT

10 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Bipolar disorder DISAM7J2 Strong Biomarker [1]
Familial adenomatous polyposis DISW53RE Strong Genetic Variation [2]
Major depressive disorder DIS4CL3X Strong Biomarker [1]
Mental disorder DIS3J5R8 Strong Biomarker [3]
Neoplasm DISZKGEW Strong Altered Expression [4]
Age-related macular degeneration DIS0XS2C moderate Genetic Variation [5]
Autism DISV4V1Z moderate Altered Expression [6]
Melanoma DIS1RRCY moderate Altered Expression [4]
Colorectal carcinoma DIS5PYL0 Disputed Biomarker [7]
Colorectal neoplasm DISR1UCN Disputed Biomarker [7]
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⏷ Show the Full List of 10 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Cadherin-7 (CDH7). [8]
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5 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin increases the expression of Cadherin-7 (CDH7). [9]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Cadherin-7 (CDH7). [10]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 increases the expression of Cadherin-7 (CDH7). [11]
Trichostatin A DM9C8NX Investigative Trichostatin A decreases the expression of Cadherin-7 (CDH7). [12]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Cadherin-7 (CDH7). [13]
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References

1 Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population.Behav Genet. 2014 Mar;44(2):97-101. doi: 10.1007/s10519-014-9645-y. Epub 2014 Feb 20.
2 MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer.Mol Med Rep. 2018 Aug;18(2):1909-1916. doi: 10.3892/mmr.2018.9215. Epub 2018 Jun 25.
3 The role of cadherin genes in five major psychiatric disorders: A literature update.Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):168-180. doi: 10.1002/ajmg.b.32592. Epub 2017 Sep 18.
4 Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration.Cancer Sci. 2009 Feb;100(2):261-8. doi: 10.1111/j.1349-7006.2008.01048.x.
5 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.Ann Hum Genet. 2013 May;77(3):215-31. doi: 10.1111/ahg.12011.
6 Cadherins and neuropsychiatric disorders.Brain Res. 2012 Aug 27;1470:130-44. doi: 10.1016/j.brainres.2012.06.020. Epub 2012 Jul 2.
7 Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.Oncology. 2005;68(2-3):246-55. doi: 10.1159/000086781. Epub 2005 Jul 7.
8 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
9 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
10 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
11 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
12 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
13 Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Cancer Prev Res (Phila). 2009 Nov;2(11):942-50. doi: 10.1158/1940-6207.CAPR-08-0232. Epub 2009 Oct 27.