Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTR2KQ6Q)

DOT Name P2Y purinoceptor 1 (P2RY1)
Synonyms P2Y1; ADP receptor; Purinergic receptor
Gene Name P2RY1
UniProt ID
P2RY1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4XNV; 4XNW; 7XXH
Pfam ID
PF00001
Sequence
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
Function
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
KEGG Pathway
Rap1 sig.ling pathway (hsa04015 )
Neuroactive ligand-receptor interaction (hsa04080 )
Platelet activation (hsa04611 )
Taste transduction (hsa04742 )
Reactome Pathway
P2Y receptors (R-HSA-417957 )
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592 )
G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Aspirin DM672AH Approved P2Y purinoceptor 1 (P2RY1) decreases the response to substance of Aspirin. [5]
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3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of P2Y purinoceptor 1 (P2RY1). [1]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of P2Y purinoceptor 1 (P2RY1). [2]
Sodium lauryl sulfate DMLJ634 Approved Sodium lauryl sulfate decreases the expression of P2Y purinoceptor 1 (P2RY1). [3]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of P2Y purinoceptor 1 (P2RY1). [4]
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References

1 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
2 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
3 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
5 Genetic determinants of response to aspirin: appraisal of 4 candidate genes. Thromb Res. 2011 Jul;128(1):47-53. doi: 10.1016/j.thromres.2011.02.019. Epub 2011 Mar 22.