Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTSO0W46)

DOT Name Coiled-coil domain-containing glutamate-rich protein 2 (CCER2)
Gene Name CCER2
Related Disease
Moyamoya disease ( )
UniProt ID
CCER2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPRGPASELLLLRLLLLGAATAAPLAPRPSKEELTRCLAEVVTEVLTVGQVQRGPCTAL
LHKELCGTEPHGCASTEEKGLLLGDFKKQEAGKMRSSQEVRDEEEEEVAERTHKSEVQEQ
AIRMQGHRQLHQEEDEEEEKEERKRGPMETFEDLWQRHLENGGDLQKRVAEKASDKETAQ
FQAEEKGVRVLGGDRSLWQGAERGGGERREDLPHHHHHHHQPEAEPRQEKEEASEREEKE
VEQLEHLRDELKKVTETLGEQLRREG
Tissue Specificity Expressed at higher levels in fetal brain and skeletal muscle. Lower expression is detected in fetal kidney, liver, spleen, thymus, heart and lung.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Moyamoya disease DISO62CA Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Coiled-coil domain-containing glutamate-rich protein 2 (CCER2). [2]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Coiled-coil domain-containing glutamate-rich protein 2 (CCER2). [3]
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References

1 Exome Sequencing Identified CCER2 as a Novel Candidate Gene for Moyamoya Disease.J Stroke Cerebrovasc Dis. 2017 Jan;26(1):150-161. doi: 10.1016/j.jstrokecerebrovasdis.2016.09.003. Epub 2016 Oct 4.
2 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
3 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.