Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTV3AWB0)

DOT Name Putative uncharacterized protein C19orf81 (C19ORF81)
Gene Name C19ORF81
UniProt ID
CS081_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15876
Sequence
MQPEVEPVCFPAMGSPTMHRKAGALLMDLETPEEMQARSLGRPIKSSKQYLRQVIAEYEA
LDRELPCIRKFPTPPASQPLCLCMETLPEEDFTHLEVLQALEAQLPGAMESGRVSSIRFE
NMNVICGTAGRRNRWLIAVTDFQTRSRLLRSGLSPRGLAHQIVRHDDLLLGDYRLHLRRS
LVRRRMLEALGAEPNEEA

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Putative uncharacterized protein C19orf81 (C19ORF81). [1]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Putative uncharacterized protein C19orf81 (C19ORF81). [2]
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References

1 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
2 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.