Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVGW9EJ)

DOT Name	C1GALT1-specific chaperone 1-like protein (C1GALT1C1L)
Gene Name	C1GALT1C1L
UniProt ID	C1C1L_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVSASGTSFFKGMLLGSISWVLITMFGQIHIRHRGQTQDHEHHHLRPPNRNDFLNTSKVI LLELSKSIRVFCIIFGESEDESYWAVLKETWTKHCDKAELYDTKNDNLFNIESNDRWVQM RTAYKYVFEKYGDNYNWFFLALPTTFAVIENLKYLLFTRDASQPFYLGHTVIFGDLEYVT VEGGIVLSRELMKRLNRLLDNSETCADQSVIWKLSEDKQLAICLKYAGVHAENAEDYEGR DVFNTKPIAQLIEEALSNNPQQVVEGCCSDMAITFNGLTPQKMEVMMYGLYRLRAFGHYF NDTLVFLPPVGSEND
KEGG Pathway	Mucin type O-glycan biosynthesis (hsa00512 ) Other types of O-glycan biosynthesis (hsa00514 ) Metabolic pathways (hsa01100 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

3 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Cisplatin	DMRHGI9	Approved	Cisplatin increases the expression of C1GALT1-specific chaperone 1-like protein (C1GALT1C1L).	[1]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of C1GALT1-specific chaperone 1-like protein (C1GALT1C1L).	[2]
Leflunomide	DMR8ONJ	Phase 1 Trial	Leflunomide decreases the expression of C1GALT1-specific chaperone 1-like protein (C1GALT1C1L).	[3]
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References

1	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
2	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
3	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.