Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTXB8H4Q)

DOT Name Ras-related protein Rab-44 (RAB44)
Gene Name RAB44
UniProt ID
RAB44_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00071
Sequence
METGQRTSRKVRKLGSNRRRQTREPADGEGAAVAPEPESWSSQAAAELQAFFQDCGAKER
GFVTREDLAVAKFSFLGSKEESEMIFDWVDVERKGHLSLEEFSSGLKNIFGSSQSPHRLR
RRKPLPSKRVSATTSFPALEEADAEEKEAFLAFMEQLGTGHLLPKQMEIWQLWGQLRQEE
PQLAGNLAGFLAKMTSRLQEAQADKEALELTLRKRDSDHHREVQQLYEEMEQQIRQEKQQ
LQAESDSRGLALTSQMQDVLEAKEREVQRLAEGQRELEAQLSHLRSTHQEAASENQQLQE
AKRDLAGRLEEVRGQLQVTRGRLDAARGRVSWQVEEKLSFPGAGEKTPDPQAASPEEAPL
PGLFGDNDDWDQLLSNFGSPPHGALQLCWSPPPTPRATSGPQTPRVVRQISISEPQAFLF
GQEPSSDPDGAPRTPPGVTFSAKDNKGVDPHEQDIRAEQPVEPHDPDPNQEPGSTPEGRL
LWGLSGSLVAPAFKVLIPLEDGPPPPANSPPPQAPAGSSKQIQASDPDDKGPGSWAPPSG
AQPGAGAGPQEPTQTPPTMTERETQPGPSPTTALTGVGPAKPPRQRDALQQDLHATGSEP
RLGTQRARALTLGPAEPFQGLEFVGPVPTERLEQGQAGPAVQEGLPEGLREAHGQVLGLG
ELSAFPHQELEEEPRSEEGKQEGRGGQDLSSEQSEQSVEAHGLETAHSELPQQDSLLVSL
PSATPQAQVEAEGPTPGKSAPPRGSPPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLT
TAHAEEQGPPHSREPRAESRLEDPGMDSREAGLTPSPGDPMAGGGPQANPDYLFHVIFLG
DSNVGKTSFLHLLHQNSFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERYHSMTR
QLLRKADGVVLMYDITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEA
GQQLAQELGVYFGECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPKRFGCC
S
Reactome Pathway
RAB geranylgeranylation (R-HSA-8873719 )
Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Ras-related protein Rab-44 (RAB44). [1]
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References

1 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.