Details of the Drug Combination

General Information of Drug Combination (ID: DC4839V)

Drug Combination Name
Bifonazole Urea
Indication
Disease Entry Status REF
Foot Dermatoses Phase 4 [1]
Component Drugs Bifonazole   DM3KN7V Urea   DMUK75B
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Bifonazole
Disease Entry ICD 11 Status REF
Fungal infection 1F29-1F2F Approved [2]
Bifonazole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Inhibitor [5]
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Indication(s) of Urea
Disease Entry ICD 11 Status REF
Dermatological disease DA24.Y Approved [3]
Exanthem N.A. Approved [4]
Impacted cerumen AA42 Approved [4]
Pityriasis simplex N.A. Approved [4]
Skin disease EA00-EM0Z Approved [4]
Tinea versicolor 1F2D.0 Approved [4]
Urea Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [6]
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Urea Interacts with 7 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Folding [7]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [8]
Aquaporin-10 (AQP10) OT8Q5UWS AQP10_HUMAN Increases Uptake [9]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Increases Chemical Synthesis [10]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Abundance [11]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Increases ADR [12]
Hemoglobin subunit alpha (HBA1) OTW2BQF4 HBA_HUMAN Increases ADR [12]
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⏷ Show the Full List of 7 DOT(s)

References

1 ClinicalTrials.gov (NCT02705664) Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%
2 Drug information of Bifonazole, 2008. eduDrugs.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4539).
4 Urea FDA Label
5 Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7.
6 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
7 Urea-induced denaturation of human serum albumin labeled with acrylodan. J Protein Chem. 2002 Feb;21(2):75-9. doi: 10.1023/a:1014508610017.
8 Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70. doi: 10.1124/jpet.105.085605. Epub 2005 Mar 29.
9 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002 Jul 19;1576(3):335-40. doi: 10.1016/s0167-4781(02)00393-7.
10 Cells for bioartificial liver devices: the human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia. Biotechnol Bioeng. 2008 Feb 15;99(3):644-51. doi: 10.1002/bit.21599.
11 Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury. Transplant Proc. 2009 Nov;41(9):3603-10. doi: 10.1016/j.transproceed.2009.04.008.
12 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.