Details of the Drug

General Information of Drug (ID: DMUK75B)

Drug Name
Urea
Synonyms
carbamide; 57-13-6; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Carbamimidic acid; Pseudourea; Ureaphil; Urevert; Carbaderm; Alphadrate; Keratinamin; Calmurid; Aquadrate; Carbonyl diamide; Pastaron; Urepearl; Carbamide resin; Ultra Mide; Varioform ii; Aqua Care; Prespersion, 75 urea; carmol; basodexan; Harnstoff; Nutraplus; Mocovina; Urea solution; Supercel 3000; Aqua Care HP; Ureacin-20; Ureacin-40 Creme; Ureacin-10 lotion; Polyurea; Panafil; Onychomal; Hyanit; Caswell No. 902; Carbonyl Diamine; Mocovina [Czech]; Harnstoff [Ge
Indication
Disease Entry ICD 11 Status REF
Dermatological disease DA24.Y Approved [1]
Exanthem N.A. Approved [2]
Impacted cerumen AA42 Approved [2]
Pityriasis simplex N.A. Approved [2]
Skin disease EA00-EM0Z Approved [2]
Tinea versicolor 1F2D.0 Approved [2]
⏷ Show the Full List of Indication(s)
ATC Code
B05BC02: Urea
B05BC: Solutions producing osmotic diuresis
B05B: I.V. SOLUTIONS
B05: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
B: BLOOD AND BLOOD FORMING ORGANS
: Urea
D02AA: Silicone products
D02A: EMOLLIENTS AND PROTECTIVES
D02: EMOLLIENTS AND PROTECTIVES
D: DERMATOLOGICALS
: Urea
D02AB: Zinc products
D02A: EMOLLIENTS AND PROTECTIVES
D02: EMOLLIENTS AND PROTECTIVES
D: DERMATOLOGICALS
: Urea
D02AC: Soft paraffin and fat products
D02A: EMOLLIENTS AND PROTECTIVES
D02: EMOLLIENTS AND PROTECTIVES
D: DERMATOLOGICALS
: Urea
D02AD: Liquid plasters
D02A: EMOLLIENTS AND PROTECTIVES
D02: EMOLLIENTS AND PROTECTIVES
D: DERMATOLOGICALS
D02AE01: Urea
D02AE: Carbamide products
D02A: EMOLLIENTS AND PROTECTIVES
D02: EMOLLIENTS AND PROTECTIVES
D: DERMATOLOGICALS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 60.056
Logarithm of the Partition Coefficient (xlogp) -1.4
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 1
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Renal failure chronic Not Available PTH1R OTQF5ZAK [3]
Renal failure chronic Not Available HBA1 OTW2BQF4 [3]
Chemical Identifiers
Formula
CH4N2O
IUPAC Name
urea
Canonical SMILES
C(=O)(N)N
InChI
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
InChIKey
XSQUKJJJFZCRTK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
1176
ChEBI ID
CHEBI:16199
CAS Number
57-13-6
UNII
8W8T17847W
DrugBank ID
DB03904
TTD ID
D02XBW
VARIDT ID
DR00048
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [5]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Gene/Protein Processing [6]
Aquaporin-10 (AQP10) OT8Q5UWS AQP10_HUMAN Regulation of Drug Effects [7]
Aquaporin-9 (AQP9) OTLGH5ZY AQP9_HUMAN Regulation of Drug Effects [8]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Biotransformations [9]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Gene/Protein Processing [10]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Gene/Protein Processing [11]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [12]
Hemoglobin subunit alpha (HBA1) OTW2BQF4 HBA_HUMAN Drug Response [3]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Drug Response [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Urea (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Levomilnacipran DMV26S8 Moderate Increased risk of hyponatremia by the combination of Urea and Levomilnacipran. Chronic pain [MG30] [13]
Vilazodone DM4LECQ Moderate Increased risk of hyponatremia by the combination of Urea and Vilazodone. Depression [6A70-6A7Z] [13]
Vortioxetine DM6F1PU Moderate Increased risk of hyponatremia by the combination of Urea and Vortioxetine. Depression [6A70-6A7Z] [13]
Milnacipran DMBFE74 Moderate Increased risk of hyponatremia by the combination of Urea and Milnacipran. Depression [6A70-6A7Z] [13]
Desvenlafaxine DMHD4PE Moderate Increased risk of hyponatremia by the combination of Urea and Desvenlafaxine. Depression [6A70-6A7Z] [13]
Eslicarbazepine DMZREFQ Moderate Increased risk of hyponatremia by the combination of Urea and Eslicarbazepine. Epilepsy/seizure [8A61-8A6Z] [14]
⏷ Show the Full List of 6 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4539).
2 Urea FDA Label
3 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
4 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
5 Urea-induced denaturation of human serum albumin labeled with acrylodan. J Protein Chem. 2002 Feb;21(2):75-9. doi: 10.1023/a:1014508610017.
6 Carcinoembryonic antigen, alpha-fetoprotein, and prostate-specific antigen in the sera of industrial workers exposed to phenol, formaldehyde, urea, and mixed vapors. Inhal Toxicol. 2006 Dec;18(13):1041-6. doi: 10.1080/08958370600904603.
7 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002 Jul 19;1576(3):335-40. doi: 10.1016/s0167-4781(02)00393-7.
8 Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. Biochem Biophys Res Commun. 1998 Mar 6;244(1):268-74. doi: 10.1006/bbrc.1998.8252.
9 Cells for bioartificial liver devices: the human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia. Biotechnol Bioeng. 2008 Feb 15;99(3):644-51. doi: 10.1002/bit.21599.
10 Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70. doi: 10.1124/jpet.105.085605. Epub 2005 Mar 29.
11 Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases. J Med Chem. 2005 Jul 14;48(14):4628-53. doi: 10.1021/jm0500931.
12 Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. Am J Physiol Renal Physiol. 2001 Nov;281(5):F983-91. doi: 10.1152/ajprenal.0358.2000.
13 Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
14 Product Information. Aptiom (eslicarbazepine). Sunovion Pharmaceuticals Inc, Marlborough, MA.