Details of the Drug Combination

General Information of Drug Combination (ID: DC4HV40)

Drug Combination Name
Bupropion Curcumin
Indication
Disease Entry Status REF
Non Small Cell Lung Cancer Phase 1 [1]
Component Drugs Bupropion   DM5PCS7 Curcumin   DMQPH29
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Bupropion
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [2]
Lung cancer 2C25.0 Approved [2]
Major depressive disorder 6A70.3 Approved [2]
Obesity 5B81 Approved [2]
Seasonal affective disorder N.A. Approved [2]
Smoking dependence 6C4A.2 Approved [3]
Bupropion Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [6]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [6]
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Bupropion Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [8]
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Bupropion Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [9]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [10]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [11]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [12]
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Bupropion Interacts with 17 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Hydrolysis [13]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [5]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [14]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [5]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Affects Expression [15]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Affects Expression [15]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [5]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [5]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [14]
Sodium-dependent dopamine transporter (SLC6A3) OT39XG28 SC6A3_HUMAN Increases Expression [16]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [5]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [15]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Affects Response To Substance [17]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Increases Response [18]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Hydroxylation [19]
Protein transport protein Sec24D (SEC24D) OTXR3KC9 SC24D_HUMAN Increases Response To Substance [16]
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⏷ Show the Full List of 17 DOT(s)
Indication(s) of Curcumin
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
Curcumin Interacts with 19 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Nitric-oxide synthase inducible (NOS2) TTF10I9 NOS2_HUMAN Inhibitor [39]
Carbonic anhydrase VI (CA-VI) TTCFSPE CAH6_HUMAN Inhibitor [40]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [40]
Multidrug resistance protein (MDR) TT0JLSD NOUNIPROTAC Inhibitor [41]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [40]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [40]
Carbonic anhydrase XIV (CA-XIV) TTEYTKG CAH14_HUMAN Inhibitor [40]
Matrix metalloproteinase-13 (MMP-13) TTHY57M MMP13_HUMAN Inhibitor [42]
Albendazole monooxygenase (CYP3A4) TTXV4FI CP3A4_HUMAN Inhibitor [43]
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [44]
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [40]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [40]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [45]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [46]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [40]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) TT6VZ78 DNM3B_HUMAN Inhibitor [47]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [46]
Amyloid beta A4 protein (APP) TTE4KHA A4_HUMAN Inhibitor [48]
DNA [cytosine-5]-methyltransferase (DNMT) TTHVCUP NOUNIPROTAC Inhibitor [47]
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⏷ Show the Full List of 19 DTT(s)
Curcumin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [49]
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Curcumin Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DE2GB8N UD18_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DEZO4N3 UD17_HUMAN Metabolism [21]
NADPH-dependent curcumin reductase (curA) DEZWDKE CURA_ECOLI Metabolism [50]
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Curcumin Interacts with 442 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [51]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [35]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [52]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Expression [53]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Activity [54]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [22]
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) OTOEEEXG HPRT_HUMAN Increases Expression [22]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Decreases Expression [22]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [22]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [22]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [22]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [22]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Expression [22]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Expression [22]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Expression [22]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Expression [22]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [22]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [22]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [22]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Increases Expression [22]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [22]
Septin-7 (SEPTIN7) OTJI08YX SEPT7_HUMAN Increases Expression [22]
Secreted frizzled-related protein 5 (SFRP5) OTLCVVSH SFRP5_HUMAN Decreases Expression [22]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [22]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Increases Expression [22]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Increases Expression [22]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [55]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [55]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [55]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Decreases Expression [55]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Increases Expression [55]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [55]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Increases Expression [23]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Increases Expression [23]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Increases Expression [23]
Dual specificity protein phosphatase CDC14B (CDC14B) OTAESVOZ CC14B_HUMAN Increases Expression [23]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [23]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Decreases Expression [23]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [23]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [23]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Decreases Expression [23]
Melanotransferrin (MELTF) OTVIUFAU TRFM_HUMAN Decreases Expression [23]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Decreases Expression [23]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [23]
B-lymphocyte antigen CD20 (MS4A1) OTZTVUBX CD20_HUMAN Decreases Expression [23]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [23]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [23]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Increases Expression [23]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [23]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Increases Expression [23]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Increases Expression [23]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) OTRA8ZVE PPIF_HUMAN Increases Expression [23]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Decreases Expression [23]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [23]
Tyrosine-protein phosphatase non-receptor type 7 (PTPN7) OTXYSIIV PTN7_HUMAN Increases Expression [23]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [23]
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) OT0AQD93 PP2BC_HUMAN Decreases Expression [23]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Decreases Expression [23]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [23]
H(+)/Cl(-) exchange transporter 6 (CLCN6) OT9QW5R4 CLCN6_HUMAN Decreases Expression [23]
Nuclear pore complex protein Nup98-Nup96 (NUP98) OTNT12G2 NUP98_HUMAN Increases Expression [23]
Diphosphomevalonate decarboxylase (MVD) OTGEX4SR MVD1_HUMAN Decreases Expression [23]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [23]
NPC intracellular cholesterol transporter 2 (NPC2) OTE9UEJC NPC2_HUMAN Decreases Expression [23]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Increases Expression [23]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Increases Expression [23]
Serine/arginine-rich splicing factor 2 (SRSF2) OTVDHO6U SRSF2_HUMAN Increases Expression [23]
Transcription factor Spi-B (SPIB) OTO4YKYI SPIB_HUMAN Increases Expression [23]
Lymphotoxin-beta (LTB) OTUFS8CF TNFC_HUMAN Increases Expression [23]
Cadherin-17 (CDH17) OT9EV2XK CAD17_HUMAN Decreases Expression [23]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Decreases Expression [23]
Lymphocyte cytosolic protein 2 (LCP2) OT57KE22 LCP2_HUMAN Increases Expression [23]
Serine/arginine-rich splicing factor 6 (SRSF6) OTGLOSYE SRSF6_HUMAN Increases Expression [23]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [23]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Decreases Expression [23]
Heme transporter HRG1 (SLC48A1) OTPFHZLO HRG1_HUMAN Increases Expression [23]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Decreases Expression [23]
BCL-6 corepressor (BCOR) OTG013AX BCOR_HUMAN Increases Expression [23]
Ankyrin repeat domain-containing protein 37 (ANKRD37) OTXSY21F ANR37_HUMAN Decreases Expression [23]
TBC1 domain family member 1 (TBC1D1) OTI9V7B0 TBCD1_HUMAN Decreases Expression [23]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Decreases Expression [23]
Secernin-2 (SCRN2) OTSG9EUS SCRN2_HUMAN Decreases Expression [23]
Beta-1,3-galactosyltransferase 6 (B3GALT6) OTF4HBAT B3GT6_HUMAN Increases Expression [23]
Dehydrogenase/reductase SDR family member 1 (DHRS1) OT8YRGCM DHRS1_HUMAN Decreases Expression [23]
Junctional sarcoplasmic reticulum protein 1 (JSRP1) OT1AAYWO JSPR1_HUMAN Decreases Expression [23]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Decreases Expression [23]
Large ribosomal subunit protein uL1m (MRPL1) OT3YIQIA RM01_HUMAN Increases Expression [23]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [23]
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) OT4LO2GJ PPDPF_HUMAN Increases Expression [23]
tRNA endonuclease ANKZF1 (ANKZF1) OTFDA384 ANKZ1_HUMAN Decreases Expression [23]
Triggering receptor expressed on myeloid cells 1 (TREM1) OTCVFEE6 TREM1_HUMAN Decreases Expression [23]
Cytohesin-4 (CYTH4) OTOR82ID CYH4_HUMAN Increases Expression [23]
Kelch-like protein 21 (KLHL21) OT28Y2LQ KLH21_HUMAN Increases Expression [23]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [23]
Calcium-activated potassium channel subunit beta-2 (KCNMB2) OTBXUQGK KCMB2_HUMAN Decreases Expression [23]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [56]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Expression [57]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [24]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [24]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [24]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [24]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Decreases Expression [24]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [24]
Regulatory factor X-associated protein (RFXAP) OTX46DKQ RFXAP_HUMAN Decreases Expression [25]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [25]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Expression [25]
Tripartite motif-containing protein 16 (TRIM16) OTLRXYOZ TRI16_HUMAN Increases Expression [25]
TBC1 domain family member 8 (TBC1D8) OT2011SS TBCD8_HUMAN Increases Expression [25]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [25]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [25]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Decreases Expression [25]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [25]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [25]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Decreases Expression [25]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [25]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Decreases Expression [25]
RNA-binding protein FUS (FUS) OTPPNGQO FUS_HUMAN Decreases Expression [25]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Decreases Expression [25]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [25]
Protein farnesyltransferase subunit beta (CHURC1-FNTB) OT34M7E3 FNTB_HUMAN Increases Expression [25]
Regulator of G-protein signaling 7 (RGS7) OTDQA90X RGS7_HUMAN Decreases Expression [25]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [25]
Large ribosomal subunit protein eL31 (RPL31) OTV9E1OE RL31_HUMAN Increases Expression [25]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [25]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Increases Expression [25]
Krueppel-like factor 10 (KLF10) OT4F4UGS KLF10_HUMAN Decreases Expression [25]
Serine/arginine-rich splicing factor 5 (SRSF5) OTC5WP98 SRSF5_HUMAN Decreases Expression [25]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [25]
RNA-binding protein 39 (RBM39) OTCMPTF9 RBM39_HUMAN Increases Expression [25]
NHL repeat-containing protein 2 (NHLRC2) OTY4HPWB NHLC2_HUMAN Decreases Expression [25]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Decreases Expression [25]
Lysophosphatidic acid receptor 1 (LPAR1) OTJNJQPF LPAR1_HUMAN Decreases Expression [25]
DNA damage-inducible transcript 4-like protein (DDIT4L) OT26Z2KN DDT4L_HUMAN Decreases Expression [25]
Constitutive coactivator of peroxisome proliferator-activated receptor gamma (FAM120B) OTGYUFOJ F120B_HUMAN Decreases Expression [25]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Decreases Expression [25]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [25]
Ankyrin repeat domain-containing protein 50 (ANKRD50) OTTLA4W2 ANR50_HUMAN Decreases Expression [25]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [25]
Regulating synaptic membrane exocytosis protein 2 (RIMS2) OTQASWDH RIMS2_HUMAN Decreases Expression [25]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [25]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [58]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [58]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [58]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Decreases Expression [59]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Increases Expression [60]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [61]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [61]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [61]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Expression [61]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [61]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [61]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [26]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [26]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Activity [62]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [63]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [64]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [64]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [64]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [64]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [27]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Increases Expression [27]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [27]
Poly polymerase tankyrase-1 (TNKS) OTVOUTPX TNKS1_HUMAN Decreases Expression [27]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [27]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Expression [27]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [27]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [27]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [27]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Decreases Expression [27]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [27]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [27]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [27]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [27]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Decreases Expression [27]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Decreases Expression [27]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Decreases Expression [27]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [27]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [27]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [27]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [27]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [27]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 7 (CDK7) OTAO19PQ CDK7_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 9 (CDK9) OT2B7OGB CDK9_HUMAN Decreases Expression [27]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [27]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [27]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Expression [27]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Decreases Expression [27]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Decreases Expression [27]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [27]
Protein kinase C epsilon type (PRKCE) OT7J0P9L KPCE_HUMAN Decreases Expression [27]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Decreases Expression [27]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Decreases Expression [27]
Interferon regulatory factor 5 (IRF5) OT8SIIAP IRF5_HUMAN Increases Expression [27]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [27]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Decreases Expression [27]
Histone deacetylase 11 (HDAC11) OTRI222R HDA11_HUMAN Decreases Expression [27]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [27]
Histone deacetylase 8 (HDAC8) OT5L4RYX HDAC8_HUMAN Decreases Expression [27]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [27]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [27]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Expression [27]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [65]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Activity [66]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [67]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Activity [67]
Glutathione S-transferase A4 (GSTA4) OTZ1USIA GSTA4_HUMAN Increases Activity [68]
Histone deacetylase 3 (HDAC3) OTC6GUV3 HDAC3_HUMAN Decreases Expression [69]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Decreases Expression [70]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [71]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Decreases Phosphorylation [72]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [38]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [73]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [65]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) OTLCYA32 G6PT1_HUMAN Decreases Expression [74]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Decreases Expression [37]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Decreases Expression [35]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Increases Expression [75]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [76]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) OT4CA13K ATS4_HUMAN Increases Expression [77]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [78]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Decreases Expression [79]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [80]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [81]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [82]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [83]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [84]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Expression [85]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Activity [86]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [87]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [67]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Decreases Expression [88]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Increases Expression [77]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [36]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Decreases Expression [89]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Increases Expression [35]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [90]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [88]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [85]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [35]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [35]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Increases Expression [91]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [92]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [28]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [88]
DNA polymerase beta (POLB) OTPJIL05 DPOLB_HUMAN Decreases Expression [93]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Decreases Expression [94]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Increases Expression [36]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [29]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [90]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Decreases Expression [38]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Activity [95]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [35]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Activity [96]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [97]
Homeobox protein Hox-B5 (HOXB5) OTU74TB8 HXB5_HUMAN Increases Expression [37]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [35]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [36]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [97]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [94]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Expression [98]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [31]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [79]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Increases Expression [99]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [65]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Activity [96]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Increases Activity [100]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Decreases Expression [97]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [70]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Activity [83]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Decreases Expression [52]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Ubiquitination [101]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [83]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Increases Expression [35]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [93]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Affects Expression [102]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Decreases Expression [38]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [29]
Prolactin receptor (PRLR) OTTHN46W PRLR_HUMAN Increases Expression [37]
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Affects Expression [102]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Ubiquitination [101]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Decreases Expression [103]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [35]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [79]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Increases Expression [31]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Phosphorylation [104]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [85]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Decreases Expression [70]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [105]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Expression [35]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [106]
Nuclear transcription factor Y subunit alpha (NFYA) OTWFFOVH NFYA_HUMAN Decreases Expression [35]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [86]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [101]
C-X-C chemokine receptor type 1 (CXCR1) OT5512B2 CXCR1_HUMAN Increases Expression [107]
C-X-C chemokine receptor type 2 (CXCR2) OTISGW7L CXCR2_HUMAN Increases Expression [107]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [35]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [36]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [67]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [108]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Decreases Expression [109]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [35]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [110]
Collagen alpha-5(IV) chain (COL4A5) OTHG60RE CO4A5_HUMAN Decreases Expression [35]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Increases Expression [31]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [105]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Increases Phosphorylation [93]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [111]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [85]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Decreases Expression [75]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [112]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Degradation [113]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Affects Expression [102]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [114]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [86]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [36]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Decreases Expression [76]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [98]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [101]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [104]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [35]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [35]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Decreases Expression [69]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Increases Expression [37]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Expression [35]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [115]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [116]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [36]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Decreases Phosphorylation [106]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [117]
Matrix metalloproteinase-14 (MMP14) OT9C197Z MMP14_HUMAN Decreases Expression [118]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [35]
Methyl-CpG-binding protein 2 (MECP2) OTREZK68 MECP2_HUMAN Decreases Expression [108]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [76]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Decreases Activity [119]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [79]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Increases Activity [36]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [82]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Increases Expression [81]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [36]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [106]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Increases Expression [35]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [29]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [120]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [92]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Activity [71]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [38]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [36]
Transcription factor Sp4 (SP4) OTWB30IZ SP4_HUMAN Decreases Expression [103]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Decreases Expression [103]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [36]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Decreases Expression [34]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [35]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) OT2CF1E6 IF4G1_HUMAN Decreases Phosphorylation [106]
Lactoylglutathione lyase (GLO1) OTXFS5B3 LGUL_HUMAN Decreases Activity [121]
Proto-oncogene c-Rel (REL) OTTCKMAC REL_HUMAN Increases Expression [81]
Macrophage-stimulating protein receptor (MST1R) OTJIPL5T RON_HUMAN Decreases Expression [122]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [35]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Phosphorylation [123]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [98]
Testican-1 (SPOCK1) OTLTDGK7 TICN1_HUMAN Increases Expression [36]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [69]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Decreases Phosphorylation [106]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [124]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [28]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Decreases Expression [35]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Decreases Expression [35]
A-kinase anchor protein 6 (AKAP6) OTN59BZS AKAP6_HUMAN Increases Expression [37]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [67]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Phosphorylation [106]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Phosphorylation [106]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Decreases Cleavage [125]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Decreases Expression [35]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [93]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [29]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [72]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Expression [105]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [38]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [73]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Decreases Expression [126]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Decreases Expression [127]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [81]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Expression [36]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Expression [79]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [98]
Polycomb protein SUZ12 (SUZ12) OT655XF8 SUZ12_HUMAN Decreases Expression [37]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Increases Expression [36]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Increases Phosphorylation [123]
Receptor-type tyrosine-protein phosphatase R (PTPRR) OT790UA2 PTPRR_HUMAN Decreases Expression [36]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [35]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Decreases Expression [35]
ETS-related transcription factor Elf-2 (ELF2) OTEI347F ELF2_HUMAN Decreases Expression [35]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [36]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [81]
Insulin-like growth factor-binding protein 7 (IGFBP7) OT1D416P IBP7_HUMAN Increases Expression [36]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [29]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Decreases Expression [98]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Increases Expression [128]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Increases Expression [37]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Increases Expression [36]
OTU domain-containing protein 7B (OTUD7B) OTMVM8R7 OTU7B_HUMAN Decreases Expression [37]
Rho GTPase-activating protein 30 (ARHGAP30) OTESZLFG RHG30_HUMAN Decreases Expression [37]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [37]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [36]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [36]
Histone H2B type 3-B (H2BC26) OT0E1H99 H2B3B_HUMAN Increases Expression [35]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [36]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Decreases Expression [129]
Unconventional myosin-XVIIIa (MYO18A) OT2YPT7O MY18A_HUMAN Increases Expression [37]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Decreases Activity [96]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Activity [130]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Decreases Expression [131]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [120]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Decreases Expression [70]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Increases Expression [84]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [73]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [70]
M-phase phosphoprotein 6 (MPHOSPH6) OT6E2S48 MPH6_HUMAN Decreases Expression [37]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [35]
Homeobox protein Nkx-3.1 (NKX3-1) OT0DO6ZU NKX31_HUMAN Decreases Expression [132]
Max dimerization protein 3 (MXD3) OT4U88UP MAD3_HUMAN Decreases Expression [35]
Synaptonemal complex protein 2 (SYCP2) OTBH622S SYCP2_HUMAN Increases Expression [37]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [133]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [72]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Decreases Expression [79]
Sideroflexin-1 (SFXN1) OTL66767 SFXN1_HUMAN Decreases Expression [37]
N-lysine methyltransferase KMT5A (KMT5A) OTW2A5YY KMT5A_HUMAN Decreases Expression [134]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [97]
NAD-dependent protein deacetylase sirtuin-7 (SIRT7) OT5M4OT4 SIR7_HUMAN Decreases Expression [135]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [133]
Interferon kappa (IFNK) OTO2WDPX IFNK_HUMAN Decreases Expression [37]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Decreases Expression [38]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Decreases Expression [35]
RAC-gamma serine/threonine-protein kinase (AKT3) OT5M2LFI AKT3_HUMAN Decreases Expression [116]
HBS1-like protein (HBS1L) OTA3U1N6 HBS1L_HUMAN Decreases Expression [37]
Cysteine protease ATG4B (ATG4B) OTQ4RNRM ATG4B_HUMAN Decreases Expression [79]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [108]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Increases Expression [35]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Response To Substance [136]
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88 Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol Pharmacol. 2006 Nov;70(5):1664-71. doi: 10.1124/mol.106.025817. Epub 2006 Jul 31.
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91 Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45. doi: 10.1016/j.bcp.2007.01.005. Epub 2007 Jan 7.
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96 Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. J Biol Chem. 2021 Jan-Jun;296:100449. doi: 10.1016/j.jbc.2021.100449. Epub 2021 Feb 20.
97 Cytotoxic effects of curcumin in human retinal pigment epithelial cells. PLoS One. 2013;8(3):e59603. doi: 10.1371/journal.pone.0059603. Epub 2013 Mar 26.
98 Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chem Biol Interact. 2021 Apr 1;338:109410. doi: 10.1016/j.cbi.2021.109410. Epub 2021 Feb 12.
99 Synergistic effects of curcumin on all-trans retinoic acid- and 1 alpha,25-dihydroxyvitamin D3-induced differentiation in human promyelocytic leukemia HL-60 cells. Oncol Res. 1997;9(1):19-29.
100 Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity. J Biol Chem. 2005 Feb 18;280(7):5221-6. doi: 10.1074/jbc.M412972200. Epub 2004 Dec 6.
101 Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol Chem. 2007 Mar 2;282(9):6707-15. doi: 10.1074/jbc.M606003200. Epub 2006 Dec 5.
102 Opposing effects of curcuminoids on serum stimulated and unstimulated angiogenic response. J Cell Physiol. 2008 Apr;215(1):251-64. doi: 10.1002/jcp.21307.
103 Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res. 2008 Jul 1;68(13):5345-54. doi: 10.1158/0008-5472.CAN-07-6805.
104 p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 2008 Mar 1;68(5):1369-77. doi: 10.1158/0008-5472.CAN-07-5222.
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106 Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther. 2008 Sep;7(9):2609-20. doi: 10.1158/1535-7163.MCT-07-2400.
107 Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. 2002 Sep 15;95(6):1206-14. doi: 10.1002/cncr.10812.
108 Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. J Breast Cancer. 2013 Mar;16(1):23-31. doi: 10.4048/jbc.2013.16.1.23. Epub 2013 Mar 31.
109 EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle. 2008 Aug;7(15):2409-17. doi: 10.4161/cc.6410. Epub 2008 Jun 9.
110 Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol. 2008 Feb;153(3):557-67. doi: 10.1038/sj.bjp.0707542. Epub 2007 Oct 29.
111 Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. Eur J Cell Biol. 2001 Mar;80(3):213-21. doi: 10.1078/0171-9335-00158.
112 Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. Carcinogenesis. 2006 Oct;27(10):2008-17. doi: 10.1093/carcin/bgl026. Epub 2006 Apr 12.
113 Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT. Cancer Sci. 2008 Dec;99(12):2518-24. doi: 10.1111/j.1349-7006.2008.00984.x. Epub 2008 Nov 17.
114 [Up-regulates the expression of maspin gene in prostate cancer cell line LNCaP]. Yao Xue Xue Bao. 2006 Dec;41(12):1152-6.
115 Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. 2009;11(6):R165. doi: 10.1186/ar2850. Epub 2009 Nov 4.
116 Curcumin inhibits esophageal squamous cell carcinoma progression through down-regulating the circNRIP1/miR-532-3p/AKT pathway. Environ Toxicol. 2023 Nov;38(11):2705-2716. doi: 10.1002/tox.23905. Epub 2023 Jul 20.
117 Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3 and -catenin pathway in A549 cell line. Chem Biol Interact. 2016 Oct 25;258:257-65. doi: 10.1016/j.cbi.2016.09.012. Epub 2016 Sep 16.
118 Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem. 2009 Feb;20(2):87-95. doi: 10.1016/j.jnutbio.2007.12.003. Epub 2008 May 20.
119 Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. Leukemia. 2006 Oct;20(10):1759-66. doi: 10.1038/sj.leu.2404350. Epub 2006 Aug 17.
120 Curcumin induces apoptosis through the mitochondria-mediated apoptotic pathway in HT-29 cells. J Zhejiang Univ Sci B. 2009 Feb;10(2):93-102. doi: 10.1631/jzus.B0820238.
121 Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. PLoS One. 2008;3(10):e3508. doi: 10.1371/journal.pone.0003508. Epub 2008 Oct 23.
122 Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. Cancer Res. 2008 Jul 1;68(13):5185-92. doi: 10.1158/0008-5472.CAN-07-6883.
123 Curcumin-induced GADD153 upregulation: modulation by glutathione. J Cell Biochem. 2007 May 15;101(2):307-20. doi: 10.1002/jcb.21179.
124 Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.
125 Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells. J Cell Biochem. 2004 May 1;92(1):200-12. doi: 10.1002/jcb.20059.
126 Therapeutic potential of curcumin in prostate cancer--V: Interference with the osteomimetic properties of hormone refractory C4-2B prostate cancer cells. Prostate. 2004 Jun 15;60(1):1-17. doi: 10.1002/pros.10359.
127 UVB-induced IL-18 production in human keratinocyte cell line NCTC 2544 through NF-kappaB activation. Cytokine. 2007 Jan;37(1):76-83. doi: 10.1016/j.cyto.2007.02.020. Epub 2007 Mar 30.
128 Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum Genet. 2008 Jan;122(6):635-43. doi: 10.1007/s00439-007-0441-0. Epub 2007 Oct 26.
129 Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol. 2008 Oct;62(5):857-65. doi: 10.1007/s00280-007-0674-6. Epub 2008 Jan 23.
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