Details of the Drug Combination

General Information of Drug Combination (ID: DC517AV)

Drug Combination Name
Heparin Aspirin
Indication
Disease Entry Status REF
Soft Tissue Neoplasms Phase 1 [1]
Component Drugs Heparin   DM4ZP3W Aspirin   DM672AH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Heparin
Disease Entry ICD 11 Status REF
Aplastic anemia 3A70 Approved [2]
Bacteremia 1A73 Approved [2]
Burns N.A. Approved [2]
Coronary heart disease BA80.Z Approved [2]
Deep vein thrombosis BD71 Approved [2]
Disseminated intravascular coagulation 3B20 Approved [2]
Metabolic disorder 5C50-5D2Z Approved [2]
Pneumonia CA40 Approved [2]
Pulmonary embolism BB00 Approved [2]
Venous thrombosis BA43 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Diabetic angiopathy BD53.Y Investigative [2]
Indication(s) of Aspirin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [5]
Adenomatous colon polyp N.A. Approved [5]
Back pain ME84.Z Approved [5]
Common cold CA00 Approved [5]
Headache 8A80-8A84 Approved [5]
Migraine disorder N.A. Approved [5]
Myocardial infarction BA41-BA43 Approved [6]
Osteoarthritis FA00-FA05 Approved [5]
Pain MG30-MG3Z Approved [7]
Cardiovascular disease BA00-BE2Z Phase 3 [7]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [8]
Colon cancer 2B90.Z Investigative [5]
Aspirin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [21]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [6]
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Aspirin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [22]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [23]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [24]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [25]
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Aspirin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [26]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [27]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [28]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [29]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Metabolism [28]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Metabolism [28]
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⏷ Show the Full List of 6 DME(s)
Aspirin Interacts with 361 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Affects Response To Substance [30]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [31]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [32]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases ADR [33]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases ADR [33]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [34]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [35]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [36]
Testis-expressed basic protein 1 (TSBP1) OT5GE8IO TSBP1_HUMAN Increases ADR [37]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases ADR [37]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Affects Response To Substance [38]
Laminin subunit alpha-1 (LAMA1) OTQZMP86 LAMA1_HUMAN Increases ADR [39]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Increases Expression [9]
Anoctamin-9 (ANO9) OTQ2UM3M ANO9_HUMAN Increases Expression [9]
PH and SEC7 domain-containing protein 1 (PSD) OTUZIXUZ PSD1_HUMAN Increases Expression [9]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [9]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Increases Expression [9]
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) OT4AVU95 MYPT1_HUMAN Decreases Expression [9]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Increases Expression [9]
Origin recognition complex subunit 4 (ORC4) OT3ACTST ORC4_HUMAN Increases Expression [9]
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) OT5FL0WU PLPL9_HUMAN Increases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) OTSQGLSB TI17B_HUMAN Increases Expression [9]
Astrotactin-2 (ASTN2) OTF0W2FJ ASTN2_HUMAN Increases Expression [9]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [9]
Trafficking protein particle complex subunit 6A (TRAPPC6A) OT0ZRV5C TPC6A_HUMAN Increases Expression [9]
DNA topoisomerase 3-beta-1 (TOP3B) OTNFEUOO TOP3B_HUMAN Increases Expression [9]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [9]
Salivary acidic proline-rich phosphoprotein 1/2 (PRH1) OTQZ6HX0 PRPC_HUMAN Decreases Expression [9]
Ribonuclease pancreatic (RNASE1) OTKZ7CO9 RNAS1_HUMAN Increases Expression [9]
Ras-related protein Ral-B (RALB) OTFH203X RALB_HUMAN Decreases Expression [9]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [9]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases Expression [9]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Increases Expression [9]
DNA excision repair protein ERCC-5 (ERCC5) OTQAKFJM ERCC5_HUMAN Increases Expression [9]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [9]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [9]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Decreases Expression [9]
Transcription initiation factor TFIID subunit 6 (TAF6) OTY1Z9C4 TAF6_HUMAN Decreases Expression [9]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Decreases Expression [9]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Increases Expression [9]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [9]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) OT21PY3J NDST2_HUMAN Increases Expression [9]
Small ubiquitin-related modifier 3 (SUMO3) OTTUJQJ1 SUMO3_HUMAN Increases Expression [9]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [9]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Decreases Expression [9]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [9]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Decreases Expression [9]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Increases Expression [9]
General transcription factor II-I (GTF2I) OTUYL1TQ GTF2I_HUMAN Decreases Expression [9]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Decreases Expression [9]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Decreases Expression [9]
Sodium channel subunit beta-1 (SCN1B) OTGD78J3 SCN1B_HUMAN Increases Expression [9]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) OTU1AIEW VPP3_HUMAN Increases Expression [9]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Decreases Expression [9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Decreases Expression [9]
TBC1 domain family member 10B (TBC1D10B) OT5MVCI5 TB10B_HUMAN Increases Expression [9]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Increases Expression [9]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [9]
DENN domain-containing protein 5A (DENND5A) OT0QNNY1 DEN5A_HUMAN Increases Expression [9]
Kinesin-like protein KIF21A (KIF21A) OT511XD9 KI21A_HUMAN Increases Expression [9]
Calcium-activated potassium channel subunit beta-4 (KCNMB4) OTYQG46B KCMB4_HUMAN Decreases Expression [9]
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) OT8L843R EFC4A_HUMAN Increases Expression [9]
Tumor protein p53-inducible protein 13 (TP53I13) OTSUH9V8 P5I13_HUMAN Increases Expression [9]
Basal body-orientation factor 1 (BBOF1) OT88DXU7 BBOF1_HUMAN Increases Expression [9]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Expression [9]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [9]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Increases Expression [9]
Sec1 family domain-containing protein 2 (SCFD2) OTYM55ET SCFD2_HUMAN Increases Expression [9]
Calcyphosin-like protein (CAPSL) OT5RRQ8E CAPSL_HUMAN Increases Expression [9]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Increases Expression [9]
Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) OTYMG99C PGTA_HUMAN Increases Expression [9]
Ribonuclease K6 (RNASE6) OTJIK1RY RNAS6_HUMAN Increases Expression [9]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [9]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [9]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (ACAP3) OTOE9OYV ACAP3_HUMAN Increases Expression [9]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [9]
Translin-associated protein X (TSNAX) OTZ9SGWB TSNAX_HUMAN Increases Expression [9]
C-C motif chemokine 19 (CCL19) OTQ2UJMH CCL19_HUMAN Increases Expression [9]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Increases Expression [9]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [9]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Increases Expression [9]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Increases Expression [9]
Intraflagellar transport protein 27 homolog (IFT27) OT3NY6O6 IFT27_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RNF26 (RNF26) OTPXA60S RNF26_HUMAN Increases Expression [9]
tRNA dimethylallyltransferase (TRIT1) OTCU9FS5 MOD5_HUMAN Increases Expression [9]
Striatin-4 (STRN4) OTHK2ZN6 STRN4_HUMAN Increases Expression [9]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [9]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Decreases Expression [9]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [9]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [9]
Tropomodulin-4 (TMOD4) OTXLGJ4R TMOD4_HUMAN Increases Expression [9]
SUN domain-containing protein 2 (SUN2) OT2IQJUC SUN2_HUMAN Increases Expression [9]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [31]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [31]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [31]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Phosphorylation [40]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [35]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [35]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [35]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [35]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [35]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Decreases Expression [35]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [35]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [35]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [35]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [35]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Increases Expression [35]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Increases Expression [35]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [35]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Increases Expression [35]
Charged multivesicular body protein 1a (CHMP1A) OTVQ5UWX CHM1A_HUMAN Decreases Expression [35]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [10]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Increases Expression [10]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Decreases Expression [10]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [10]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [10]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [10]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [10]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Decreases Expression [10]
Pulmonary surfactant-associated protein D (SFTPD) OTNKPDJC SFTPD_HUMAN Increases Expression [10]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [10]
RNA-binding protein FXR2 (FXR2) OTQX7ATF FXR2_HUMAN Decreases Expression [10]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [10]
Hemoglobin subunit gamma-2 (HBG2) OT4J48JJ HBG2_HUMAN Increases Expression [10]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Decreases Expression [10]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [10]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Increases Expression [10]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) OTX2UA7P IQGA2_HUMAN Increases Expression [10]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [10]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Increases Expression [10]
Centromere protein S (CENPS) OTZ4J391 CENPS_HUMAN Increases Expression [10]
LIM domain only protein 7 (LMO7) OTDLY6TC LMO7_HUMAN Increases Expression [10]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Decreases Expression [10]
N-alpha-acetyltransferase 38, NatC auxiliary subunit (NAA38) OTI8VWK3 LSMD1_HUMAN Increases Expression [10]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [10]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Increases Expression [10]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Decreases Expression [10]
Pseudouridylate synthase 1 homolog (PUS1) OTS2DQ0N PUS1_HUMAN Increases Expression [10]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [11]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Increases Expression [11]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [11]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [11]
Tumor protein D54 (TPD52L2) OTTOG0NK TPD54_HUMAN Decreases Expression [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [11]
GDNF family receptor alpha-3 (GFRA3) OT07XAZF GFRA3_HUMAN Increases Expression [11]
Tetraspanin-3 (TSPAN3) OT7WS6ZI TSN3_HUMAN Decreases Expression [11]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Increases Expression [11]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [11]
Gamma-aminobutyric acid receptor-associated protein (GABARAP) OTAQUX6E GBRAP_HUMAN Decreases Expression [11]
Histone acetyltransferase KAT7 (KAT7) OTUN98IC KAT7_HUMAN Decreases Expression [11]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Increases Expression [11]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Decreases Expression [11]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [11]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Decreases Expression [11]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Decreases Expression [11]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [11]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Decreases Expression [11]
Argininosuccinate lyase (ASL) OTI2NGQR ARLY_HUMAN Decreases Expression [11]
Calpain small subunit 1 (CAPNS1) OT95EBBD CPNS1_HUMAN Decreases Expression [11]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OTEG4KU9 RPN1_HUMAN Decreases Expression [11]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Expression [11]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [11]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [11]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Expression [11]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [11]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [11]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Expression [11]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Decreases Expression [11]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Increases Expression [11]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [11]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [11]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Increases Expression [11]
Probable ATP-dependent RNA helicase DDX5 (DDX5) OTLS124U DDX5_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase TRIM21 (TRIM21) OTA4UJCF RO52_HUMAN Decreases Expression [11]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Decreases Expression [11]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Increases Expression [11]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [11]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [11]
Granulysin (GNLY) OTZJKA8C GNLY_HUMAN Decreases Expression [11]
Peptidyl-prolyl cis-trans isomerase B (PPIB) OTLPH6KN PPIB_HUMAN Decreases Expression [11]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Decreases Expression [11]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Decreases Expression [11]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [11]
Cytokine receptor common subunit gamma (IL2RG) OTRZ3OMY IL2RG_HUMAN Decreases Expression [11]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Decreases Expression [11]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Decreases Expression [11]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [11]
Protein DEK (DEK) OTYCJ5H6 DEK_HUMAN Increases Expression [11]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [11]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Expression [11]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [11]
Dual specificity protein kinase CLK2 (CLK2) OT1CRSY2 CLK2_HUMAN Decreases Expression [11]
Dual specificity protein kinase CLK3 (CLK3) OT74DJ3J CLK3_HUMAN Decreases Expression [11]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [11]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [11]
F-actin-capping protein subunit alpha-1 (CAPZA1) OTAXA66U CAZA1_HUMAN Increases Expression [11]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [11]
Protein SEC13 homolog (SEC13) OTSR4WWM SEC13_HUMAN Decreases Expression [11]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [11]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Expression [11]
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) OT4B0TNV PP4C_HUMAN Decreases Expression [11]
V-type proton ATPase subunit d 1 (ATP6V0D1) OT9GU2NW VA0D1_HUMAN Decreases Expression [11]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [11]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [11]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Increases Expression [11]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [11]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [11]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Increases Expression [11]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Decreases Expression [11]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [11]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) OTQ2959Y KLRB1_HUMAN Increases Expression [11]
Protein flightless-1 homolog (FLII) OT7G9JG6 FLII_HUMAN Decreases Expression [11]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [11]
Peptidyl-prolyl cis-trans isomerase G (PPIG) OTZ8BTTM PPIG_HUMAN Increases Expression [11]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [11]
Flotillin-2 (FLOT2) OTZ0QR5L FLOT2_HUMAN Decreases Expression [11]
Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) OT2YERNV PTCA_HUMAN Decreases Expression [11]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [11]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [11]
Myeloid leukemia factor 2 (MLF2) OTU3B4WU MLF2_HUMAN Decreases Expression [11]
Protein NKG7 (NKG7) OTXDD006 NKG7_HUMAN Decreases Expression [11]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Decreases Expression [11]
All-trans retinoic acid-induced differentiation factor (ATRAID) OTOHZG1O ARAID_HUMAN Decreases Expression [11]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Increases Expression [11]
F-box only protein 11 (FBXO11) OTGWF3Q2 FBX11_HUMAN Increases Expression [11]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Decreases Expression [11]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Increases Expression [11]
Pumilio homolog 2 (PUM2) OT2H7NXV PUM2_HUMAN Increases Expression [11]
PEST proteolytic signal-containing nuclear protein (PCNP) OTJUQ122 PCNP_HUMAN Increases Expression [11]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [11]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [11]
Protein TFG (TFG) OT2KJENI TFG_HUMAN Increases Expression [11]
Ninjurin-1 (NINJ1) OTLRZ1EU NINJ1_HUMAN Decreases Expression [11]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Expression [11]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Decreases Expression [11]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Decreases Expression [11]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [11]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Decreases Expression [11]
Programmed cell death protein 10 (PDCD10) OTCHJTSF PDC10_HUMAN Increases Expression [11]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Decreases Expression [11]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [11]
Large ribosomal subunit protein mL46 (MRPL46) OTMQ2A0Q RM46_HUMAN Increases Expression [11]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [11]
Mediator of RNA polymerase II transcription subunit 4 (MED4) OTALFN4S MED4_HUMAN Increases Expression [11]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [11]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [11]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Decreases Expression [11]
Tyrosine-protein kinase BAZ1B (BAZ1B) OTD5KR2J BAZ1B_HUMAN Decreases Expression [11]
F-box/LRR-repeat protein 3 (FBXL3) OTDQ1QKV FBXL3_HUMAN Increases Expression [11]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) OTK81F92 ACINU_HUMAN Decreases Expression [11]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [11]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [41]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [42]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [42]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [42]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [43]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [43]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [44]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [45]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [32]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [32]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [43]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [46]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [47]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Expression [43]
Ornithine transcarbamylase, mitochondrial (OTC) OTJ57GGA OTC_HUMAN Decreases Expression [48]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Cleavage [49]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [50]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [51]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [43]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Secretion [52]
Fibrinogen beta chain (FGB) OT6RKLI9 FIBB_HUMAN Decreases Secretion [52]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Secretion [52]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [43]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [53]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [54]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [55]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [56]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Expression [44]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [57]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [58]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [43]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Affects Methylation [59]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [60]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Activity [61]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [62]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [63]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [43]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [12]
N-formyl peptide receptor 2 (FPR2) OTEZ2THZ FPR2_HUMAN Increases Expression [64]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [43]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [43]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [65]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [43]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [65]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [66]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [43]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Localization [62]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [67]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [43]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [43]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [15]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [36]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [58]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [68]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [12]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [69]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [70]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [63]
Dermcidin (DCD) OTV5PBGJ DCD_HUMAN Decreases Secretion [52]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [44]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [71]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [43]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [72]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Localization [73]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [74]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [69]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [58]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Expression [58]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [43]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [75]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [43]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [43]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [46]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [46]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Decreases Expression [70]
Gastrokine-1 (GKN1) OT7ZYFQ9 GKN1_HUMAN Affects Expression [76]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [43]
Cysteinyl leukotriene receptor 1 (CYSLTR1) OT904HBN CLTR1_HUMAN Increases Expression [77]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Increases Expression [78]
Voltage-dependent calcium channel gamma-6 subunit (CACNG6) OT2PC1E1 CCG6_HUMAN Affects Response To Substance [79]
Platelet glycoprotein Ib alpha chain (GP1BA) OT62PSOB GP1BA_HUMAN Increases Response To Substance [80]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases ADR [39]
Regulator of G-protein signaling 7-binding protein (RGS7BP) OTAGSWMH R7BP_HUMAN Affects Response To Substance [81]
Serine/threonine-protein kinase 10 (STK10) OTC33Y2F STK10_HUMAN Affects Response To Substance [82]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Hydrolysis [83]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [84]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases ADR [39]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Affects Response To Substance [85]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Affects Response To Substance [86]
Leucine-rich melanocyte differentiation-associated protein (LRMDA) OTIPNKTU LRMDA_HUMAN Increases ADR [34]
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) OTIRUOHF FCERA_HUMAN Affects Response To Substance [87]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Affects Response To Substance [88]
High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) OTMCAS2D FCERB_HUMAN Affects Response To Substance [89]
Stromal membrane-associated protein 2 (SMAP2) OTPGVRKO SMAP2_HUMAN Affects Response To Substance [90]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Affects Response To Substance [91]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Increases ADR [18]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Increases ADR [92]
Cysteinyl leukotriene receptor 2 (CYSLTR2) OTRNEOZ0 CLTR2_HUMAN Affects Response To Substance [87]
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33) OTRZVI77 ADA33_HUMAN Affects Response To Substance [93]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Affects Response To Substance [94]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Affects Response To Substance [86]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [95]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Affects Response To Substance [96]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Affects Response To Substance [97]
Galectin-10 (CLC) OTYMYR85 LEG10_HUMAN Affects Response To Substance [98]
Centrosomal protein of 68 kDa (CEP68) OTZDM4J1 CEP68_HUMAN Affects Response To Substance [99]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Affects Response To Substance [100]
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⏷ Show the Full List of 361 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Pregnancy DC1950E N. A. Phase 4 [101]
Thrombophilia With Recurrent Pregnancy Loss DCLV82T N. A. Phase 4 [102]
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101 ClinicalTrials.gov (NCT01917799) Aspirin, Heparin and Miscarriage
102 ClinicalTrials.gov (NCT02986594) Diagnosis and Treatment Strategy of Recurrent Spontaneous Abortion Associated With Thrombophilla